LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental

O Laboratório de Pesquisa em Cirurgia Experimental é ligado ao Departamento de Cirurgia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: trauma, choque, sepse, substitutos artificiais do sangue, isquemia e reperfusão, disfunção de múltiplos órgãos, transplantes, pré-condicionamento isquêmico; células-tronco na paraplegia; substitutos vasculares; reposição volêmica; soluções hiperténicas; perfusão esplâncnica; marcadores prognósticos de tumor; angiogênese; imunopatologia de modelos experimentais; imunologias de modelos experimentais; cirurgia minimamente invasiva; oncologia experimental; morfologia e biomecânica da aorta.

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Recent Submissions

  1. Laser-evoked potentials recover gradually when using dorsal root ganglion stimulation, and this influences nociceptive pathways in neuropathic pain patients

    PAIN PRACTICE, v.22, n.3, p.372-380, 2022

    Objective Dorsal root ganglion stimulation (DRGS) is able to relieve chronic neuropathic pain. There seems evidence that DRGS might achieve this by gradually influencing pain pathways. We used laser-evoked potentials (LEP) to verify our hypothesis that the recovery of the LEP may reflect DRGS-ind...

  2. What Does the General Public Know (or Not) About Neuroscience? Effects of Age, Region and Profession in Brazil

    FRONTIERS IN HUMAN NEUROSCIENCE, v.16, article ID 798967, 13p, 2022

    The field of Neuroscience has experienced a growing interest in recent decades, which has led to an exponential growth in the amount of related information made available online as well as the market for Neuroscience-related courses. While this type of knowledge can be greatly beneficial to peopl...

  3. Beyond the Standard of Care: An Exploratory Qualitative Study of an Implemented Integrative Therapeutic Care Program in a Brazilian Pediatric Oncology Unit


    Introduction: This article examines the feedback of health care providers within the implementation of an integrative care project in a clinic for pediatric oncology in Sao Paulo, Brazil. Since 2017, the project has implemented external anthroposophic therapies in the activities of daily nursing....

  4. Impact of Three Methods of Ischemic Preconditioning on Ischemia-Reperfusion Injury in a Pig Model of Liver Transplantation

    JOURNAL OF INVESTIGATIVE SURGERY, v.35, n.4, p.900-909, 2022

    Background Ischemic preconditioning (IPC), either direct (DIPC) or remote (RIPC), is a procedure aimed at reducing the harmful effects of ischemia-reperfusion (I/R) injury. Objectives To assess the local and systemic effects of DIPC, RIPC, and both combined, in the pig liver transplant model. Mat...

  5. Omega-3 Fatty Acid Supplementation and Its Impact on Systemic Inflammation and Body Weight in Patients With Cancer Cachexia-A Systematic Review and Meta-Analysis

    FRONTIERS IN NUTRITION, v.8, article ID 797513, 11p, 2022

    Body weight loss and inflammation are major alterations related to cancer cachexia, an important wasting syndrome highly prevalent in many types of cancer. Nutritional components modulate inflammation in several chronic diseases. Omega-3 fatty acids (n-3) are well known for their anti-inflammator...

  6. Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity

    JOURNAL OF NUTRITION, v.152, n.3, p.663-670, 2022

    Background Approximately 10% of adolescents worldwide are overweight or obese, hence the urgent and universal need to elucidate possible mechanisms that lead to obesity in the adolescent population. Objectives We examined the hypothalamic metabolism and its relationship with physical development ...

  7. Photodynamic Therapy (PDT), Radiofrequency Ablation (RFA) With Biliary Stents in Palliative Treatment of Unresectable Extrahepatic Cholangiocarcinoma A Systematic Review and Meta-analysis

    JOURNAL OF CLINICAL GASTROENTEROLOGY, v.56, n.2, p.E153-E160, 2022

    Background and Aim: Extrahepatic unresectable cholangiocarcinoma carries a dismal prognosis. In addition to biliary drainage by stent placement; photodynamic therapy (PDT) and radiofrequency ablation (RFA) have been tried to prolong survival. In this meta-analysis, we appraise the current known d...

  8. Aging Aggravates Cachexia in Tumor-Bearing Mice

    CANCERS, v.14, n.1, article ID 90, 21p, 2022

    Simple Summary Cachexia is a deadly disease that accompanies many different types of cancers. Animal studies on cachexia have so far mostly been conducted using young mice, while cancer in humans is a disease of high age. Mouse models used to date may therefore not be suitable to study cachexia w...

  9. Major Depression in patients with Crohn's disease and its relationship with clinical activity and disease's phenotype

    JOURNAL OF CROHNS & COLITIS, v.15, suppl.1, p.S282-S283, 2021

  10. A higher prevalence of human papillomavirus in patients with perianal fistulizing Crohn's disease compared to patients with anorectal fistula without Crohn's disease

    JOURNAL OF CROHNS & COLITIS, v.15, suppl.1, p.S563-S563, 2021