LIM/27 - Laboratório de Neurociências

O Laboratório de Neurociências é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: expressão gênica em amostras cerebrais e outros tecidos derivados de pacientes com doenças neuropsiquiátricas; farmacogenética; biologia celular e culturas primárias de neurônios; ressonância magnética e espectroscopia; metabolismo de fosfolípedes na membrana neuronal; estudos clínico-epidemiológicos e ensaios farmacêuticos; biomarcadores moleculares em doenças neuropsiquiátricas; lítio e neuroproteção na doença de Alzheimer, modelos animais em doenças neuropsiquiátricas.

Site oficial: http://limhc.fm.usp.br/portal/lim27-laboratorio-de-neurociencias/

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Recent Submissions

  1. Polygenic risk scores across the extended psychosis spectrum

    TRANSLATIONAL PSYCHIATRY, v.11, n.1, article ID 600, 11p, 2021

    As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the ...

  2. Subcortical Aphasia

    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, v.21, n.12, article ID 73, 15p, 2021

    Purpose of Review Subcortical structures have long been thought to play a role in language processing. Increasingly spirited debates on language studies, arising from as early as the nineteenth century, grew remarkably sophisticated as the years pass. In the context of non-thalamic aphasia, a few...

  3. Semantic priming and neurobiology in schizophrenia: A theoretical review

    NEUROPSYCHOLOGIA, v.163, article ID 108058, 21p, 2021

    In this theoretical review we bridge the cognitive and neurobiological sciences to shed light on the neurocognitive foundations of the semantic priming effect in schizophrenia. We review and theoretically evaluate the neurotransmitter systems (dopaminergic, GABAergic and glutamatergic) and neurob...

  4. Textual Inference Comprehension in Mild Cognitive Impairment: The Influence of Semantic Processing and Verbal Episodic Memory

    FRONTIERS IN AGING NEUROSCIENCE, v.13, article ID 735633, 10p, 2021

    Language complaints, especially in complex tasks, may occur in mild cognitive impairment (MCI). Various language measures have been studied as cognitive predictors of MCI conversion to Alzheimer's type dementia. Understanding textual inferences is considered a high-demanding task that recruits mu...

  5. Cortical surface abnormalities are different depending on the stage of schizophrenia: A cross-sectional vertexwise mega-analysis of thickness, area and gyrification

    SCHIZOPHRENIA RESEARCH, v.236, p.104-114, 2021

    Background: Brain magnetic resonance imaging studies have not investigated the cortical surface comprehensively in schizophrenia subjects by assessing thickness, surface area and gyrification separately during the first episode of psychosis (FEP) or chronic schizophrenia (ChSch). Methods: We inve...

  6. AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State

    JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, v.34, n.6, Special Issue, p.659-667, 2021

    Aim: Associations between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) with the severity of cognitive impairment are unclear. We examined the correlations between CSF biomarkers and cognitive performance in the AD continuum. Methods: We studied 143 elderly patients: cognitivel...

  7. In vivo imaging evidence of poor cognitive resilience to Alzheimer's disease pathology in subjects with very low cognitive reserve from a low-middle income environment

    ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, v.12, n.1, article ID e12122, 11p, 2020

    INTRODUCTION: Reduced cognitive reserve (CR) due to very low educational (VLE) levels may influence high dementia rates in low-middle income environments, leading to decreased cognitive resilience (RES) to Alzheimers disease (AD) pathology. However, in vivo findings in VLE groups confirming this ...

  8. Increased PLA(2) activity in individuals at ultra-high risk for psychosis

    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.271, n.8, p.1593-1599, 2021

    Phospholipase A(2) is the main enzyme in the metabolism of membrane phospholipids. It comprises a family of enzymes divided into iPLA(2), cPLA(2) and sPLA(2). Studies have reported increased PLA(2) activity in psychotic patients, which suggests an accelerated breakdown of membrane phospholipids. ...

  9. Non-invasive cortical stimulation: Transcranial direct current stimulation (tDCS)

    EMERGING HORIZONS IN NEUROMODULATION: NEW FRONTIERS IN BRAIN AND SPINE STIMULATION, v.159, p.1-22, 2021

    Transcranial direct current stimulation (tDCS) is a re-emerging non-invasive brain stimulation technique that has been used in animal models and human trials aimed to elucidate neurophysiology and behavior interactions. It delivers subthreshold electrical currents to neuronal populations that shi...

  10. Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder

    MOLECULAR PSYCHIATRY, v.26, n.9, p.4583-4604, 2021

    An important challenge in mental health research is to translate findings from cognitive neuroscience and neuroimaging research into effective treatments that target the neurobiological alterations involved in psychiatric symptoms. To address this challenge, in this review we propose a heuristic ...