LIM/27 - Laboratório de Neurociências

O Laboratório de Neurociências é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: expressão gênica em amostras cerebrais e outros tecidos derivados de pacientes com doenças neuropsiquiátricas; farmacogenética; biologia celular e culturas primárias de neurônios; ressonância magnética e espectroscopia; metabolismo de fosfolípedes na membrana neuronal; estudos clínico-epidemiológicos e ensaios farmacêuticos; biomarcadores moleculares em doenças neuropsiquiátricas; lítio e neuroproteção na doença de Alzheimer, modelos animais em doenças neuropsiquiátricas.

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Recent Submissions

  1. Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

    MOLECULAR PSYCHIATRY, v.27, n.2, p.1167-1176, 2022

    Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of...

  2. Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine


    Major depression, bipolar disorder, and schizophrenia are severe mental illnesses. Despite receiving psychopharmacological and psychosocial treatments, about half of patients develop a chronic course with residual cognitive and negative symptoms and have a high risk for cardiovascular disease and...

  3. Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health

    FRONTIERS IN PSYCHIATRY, v.13, article ID 815718, 16p, 2022

    The Federal Ministry of Education and Research (BMBF) issued a call for a new nationwide research network on mental disorders, the German Center of Mental Health (DZPG). The Munich/Augsburg consortium was selected to participate as one of six partner sites with its concept ""Precision in Mental H...

  4. Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

    CELLS, v.11, n.2, article ID 241, 25p, 2022

    Oligodendrocytes (OLs) are critical for myelination and are implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression of different combinations of the transcription factors SOX10 (S), OLIG2 (O), and...

  5. Longitudinal reciprocal associations between depression, anxiety, and substance use disorders over three decades of life

    JOURNAL OF AFFECTIVE DISORDERS, v.302, p.315-323, 2022

    Background and objective: Studies exploring longitudinal reciprocal associations between depressive, anxiety, and substance use disorders (DD, AD and SUD, respectively) over long periods of time are mainly lacking. Therefore, the aim of the present study is to test longitudinal associations (i.e....

  6. Cultural adaptation of the mental health first aid guidelines for Brazilians with problem drinking: a Delphi expert consensus study

    BMC PSYCHIATRY, v.22, n.1, article ID 168, 8p, 2022

    Background Harmful use of alcohol is highly prevalent around the world and results in a large disease burden. Most people who meet the criteria for an alcohol use disorder do not receive treatment. Those in a person's social network can be useful in recognizing a problem and encouraging the perso...

  7. Human endogenous retrovirus and multiple sclerosis: A review and transcriptome findings

    MULTIPLE SCLEROSIS AND RELATED DISORDERS, v.57, article ID 103383, 7p, 2022

    Multiple Sclerosis is an autoimmune disease with an unknown etiology. Both genetic and environmental factors are believed to trigger MS autoimmunity. Among the environmental factors, infectious agents have been extensively investigated, and the Human Endogenous Retroviruses (HERVs), especially HE...

  8. Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association

    ENVIRONMENTAL RESEARCH, v.207, article ID 112183, 11p, 2022

    In urban ecosystems, microbes play a key role in maintaining major ecological functions that directly support human health and city life. However, the knowledge about the species composition and functions involved in urban environments is still limited, which is largely due to the lack of referen...

  9. Inhibition of TRPM2 by AG490 Is Neuroprotective in a Parkinson's Disease Animal Model

    MOLECULAR NEUROBIOLOGY, v.59, n.3, p.1543-1559, 2022

    Parkinson's disease (PD) is characterized by motor impairment and dopaminergic neuronal loss. There is no cure for the disease, and treatments have several limitations. The transient receptor potential melastatin 2 (TRPM2), a calcium-permeable non-selective cation channel, has been reported to be...

  10. Neuronal-Glial Interaction in a Triple-Transgenic Mouse Model of Alzheimer's Disease: Gene Ontology and Lithium Pathways (vol 14, 579984, 2020)

    FRONTIERS IN NEUROSCIENCE, v.15, article ID 726983, 1p, 2021