LIM/27 - Laboratório de Neurociências

O Laboratório de Neurociências é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: expressão gênica em amostras cerebrais e outros tecidos derivados de pacientes com doenças neuropsiquiátricas; farmacogenética; biologia celular e culturas primárias de neurônios; ressonância magnética e espectroscopia; metabolismo de fosfolípedes na membrana neuronal; estudos clínico-epidemiológicos e ensaios farmacêuticos; biomarcadores moleculares em doenças neuropsiquiátricas; lítio e neuroproteção na doença de Alzheimer, modelos animais em doenças neuropsiquiátricas.

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Recent Submissions

  1. Longitudinal reciprocal associations between depression, anxiety, and substance use disorders over three decades of life

    JOURNAL OF AFFECTIVE DISORDERS, v.302, p.315-323, 2022

    Background and objective: Studies exploring longitudinal reciprocal associations between depressive, anxiety, and substance use disorders (DD, AD and SUD, respectively) over long periods of time are mainly lacking. Therefore, the aim of the present study is to test longitudinal associations (i.e....

  2. Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

    CELLS, v.11, n.2, article ID 241, 25p, 2022

    Oligodendrocytes (OLs) are critical for myelination and are implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression of different combinations of the transcription factors SOX10 (S), OLIG2 (O), and...

  3. Cultural adaptation of the mental health first aid guidelines for Brazilians with problem drinking: a Delphi expert consensus study

    BMC PSYCHIATRY, v.22, n.1, article ID 168, 8p, 2022

    Background Harmful use of alcohol is highly prevalent around the world and results in a large disease burden. Most people who meet the criteria for an alcohol use disorder do not receive treatment. Those in a person's social network can be useful in recognizing a problem and encouraging the perso...

  4. Human endogenous retrovirus and multiple sclerosis: A review and transcriptome findings

    MULTIPLE SCLEROSIS AND RELATED DISORDERS, v.57, article ID 103383, 7p, 2022

    Multiple Sclerosis is an autoimmune disease with an unknown etiology. Both genetic and environmental factors are believed to trigger MS autoimmunity. Among the environmental factors, infectious agents have been extensively investigated, and the Human Endogenous Retroviruses (HERVs), especially HE...

  5. Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association

    ENVIRONMENTAL RESEARCH, v.207, article ID 112183, 11p, 2022

    In urban ecosystems, microbes play a key role in maintaining major ecological functions that directly support human health and city life. However, the knowledge about the species composition and functions involved in urban environments is still limited, which is largely due to the lack of referen...

  6. Inhibition of TRPM2 by AG490 Is Neuroprotective in a Parkinson's Disease Animal Model

    MOLECULAR NEUROBIOLOGY, v.59, n.3, p.1543-1559, 2022

    Parkinson's disease (PD) is characterized by motor impairment and dopaminergic neuronal loss. There is no cure for the disease, and treatments have several limitations. The transient receptor potential melastatin 2 (TRPM2), a calcium-permeable non-selective cation channel, has been reported to be...

  7. Plasmatic endocannabinoids are decreased in subjects with ultra-high risk of psychosis

    EUROPEAN JOURNAL OF NEUROSCIENCE, v.55, n.4, Special Issue, p.1079-1087, 2022

    The onset of frank psychosis is usually preceded by a prodromal phase characterized by attenuated psychotic symptoms. Currently, research on schizophrenia prodromal phase (ultra-high risk for psychosis [UHR]) has focused on the risk of developing psychosis, on the transition to full blown psychos...

  8. Neuronal-Glial Interaction in a Triple-Transgenic Mouse Model of Alzheimer's Disease: Gene Ontology and Lithium Pathways (vol 14, 579984, 2020)

    FRONTIERS IN NEUROSCIENCE, v.15, article ID 726983, 1p, 2021

  9. Use of a Bayesian Network Model to predict psychiatric illness in individuals with 'at risk mental states' from a general population cohort

    NEUROSCIENCE LETTERS, v.770, article ID 136358, 6p, 2022

    The 'at risk mental state' (ARMS) paradigm has been introduced in psychiatry to study prodromal phases of schizophrenia. With time it was seen that the ARMS state can also precede mental disorders other than schizophrenia, such as depression and anxiety. However, several problems hamper the parad...

  10. Translation and validation of the Structured Interview for Prodromal Syndromes (SIPS) to Portuguese

    BRAZILIAN JOURNAL OF PSYCHIATRY, v.43, n.5, p.560-562, 2021