LIM/27 - Laboratório de Neurociências

O Laboratório de Neurociências é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: expressão gênica em amostras cerebrais e outros tecidos derivados de pacientes com doenças neuropsiquiátricas; farmacogenética; biologia celular e culturas primárias de neurônios; ressonância magnética e espectroscopia; metabolismo de fosfolípedes na membrana neuronal; estudos clínico-epidemiológicos e ensaios farmacêuticos; biomarcadores moleculares em doenças neuropsiquiátricas; lítio e neuroproteção na doença de Alzheimer, modelos animais em doenças neuropsiquiátricas.

Site oficial: http://limhc.fm.usp.br/portal/lim27-laboratorio-de-neurociencias/

Browse

Recent Submissions

  1. Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis

    SCHIZOPHRENIA BULLETIN, v.49, n.6, p.1614-1624, 2023

    Background and Hypothesis Cognitive impairment is a hallmark of schizophrenia, but no effective treatment is available to date. The underlying pathophysiology includes disconnectivity between hippocampal and prefrontal brain regions. Supporting evidence comes from diffusion-weighted imaging studi...

  2. New treatment strategies for mental health

    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.273, n.7, p.1399-1401, 2023

  3. Cellular pathology in the limbic system in schizophrenia

    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.273, n.6, p.1207-1208, 2023

  4. Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic

    FRONTIERS IN PUBLIC HEALTH, v.12, article ID 1369129, 15p, 2024

    Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management r...

  5. Employment, education, and clinical characteristics in older-age bipolar disorder: Analysis from the GAGE-BD database project

    BIPOLAR DISORDERS, v.25, suppl.1, Special Issue, p.93-93, 2023

  6. Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study

    SCHIZOPHRENIA BULLETIN, v.50, n.1, p.145-156, 2024

    Background and Hypothesis: Aerobic exercise interventions in people with schizophrenia have been demonstrated to improve clinical outcomes, but findings regarding the underlying neural mechanisms are limited and mainly focus on the hippocampal formation. Therefore, we conducted a global explorato...

  7. Publishing Negative Results of Neurobiological Studies in Mental Disorders Will Advance Knowledge in Pathophysiology

    SCHIZOPHRENIA BULLETIN, v.49, n.3, p.539-541, 2023

  8. Exercise as an add-on treatment in individuals with schizophrenia: Results from a large multicenter randomized controlled trial

    PSYCHIATRY RESEARCH, v.328, article ID 115480, 11p, 2023

    Current treatment methods do not achieve recovery for most individuals with schizophrenia, and symptoms such as negative symptoms and cognitive deficits often persist. Aerobic endurance training has been suggested as a potential add-on treatment targeting both physical and mental health. We perfo...

  9. Treatment of negative symptoms in schizophrenia: a challenge for clinical research

    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.273, n.3, p.525-526, 2023

  10. The relationship between internet gaming disorder and psychotic experiences: cyberbullying and insomnia severity as mediators

    BMC PSYCHIATRY, v.23, n.1, article ID 857, 14p, 2023

    BackgroundThe nature of the relationship between Internet Gaming Disorder (IGD) and psychosis is unclear so far. There is evidence that greater time spent in playing video games may expose players to both insomnia and a toxic online environment with widespread cyberbullying. These two possible co...