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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSERINI, Simona
dc.contributor.authorGUARINO, Roberta
dc.contributor.authorVASCONCELOS, Renata Ottes
dc.contributor.authorCELLENO, Leonardo
dc.contributor.authorCALVIELLO, Gabriella
dc.date.accessioned2020-08-20T13:26:14Z-
dc.date.available2020-08-20T13:26:14Z-
dc.date.issued2020
dc.identifier.citationNUTRIENTS, v.12, n.6, article ID 1608, 21p, 2020
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37049-
dc.description.abstractPlenty of evidence supports the health effects exerted by dietary supplements containing phytochemicals, but the actual efficacy and safety of their combinations have been seldom experimentally evaluated. On this basis, we investigated in vitro the antioxidant/antineoplastic efficacy and anti-aging activity of a dietary supplement containing sulforaphane (SFN), a sulfur-isothiocyanate present in broccoli, combined with the patented extract Fernblock(R)XP (FB), obtained from the tropical fernPolypodium leucotomos. We evaluated the effect of SFN and FB, alone or in combination, on migration ability, matrix metalloproteinases (MMP) production, neoangiogenic potential and inflammasome activation in human WM115 and WM266-4 melanoma cells. Moreover, the effects on MMPs and reactive oxygen species production, and IL-1 beta secretion were studied in human normal keratinocytes. The SFN/FB combination inhibited melanoma cell migration in vitro, MMP-1, -2, -3, and -9 production, inflammasome activation and IL-1 beta secretion more efficiently than each individual compound did. In normal keratinocytes, SFN/FB was more efficient than SFN or FB alone in inhibiting MMP-1 and -3 production and IL-1 beta secretion in the presence of a pro-inflammatory stimulus such as TNF-alpha. The potential use of SFN/FB based supplements for the prevention of skin aging and as adjuvants in the treatment of advanced melanoma is suggested.eng
dc.description.sponsorshipUniversita Cattolica del S. Cuore, Rome, Italy
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofNutrients
dc.rightsopenAccesseng
dc.subjectmelanoma cellseng
dc.subjectkeratinocyteseng
dc.subjectFernblock(R)XPeng
dc.subjectsulforaphaneeng
dc.subjectmigrationeng
dc.subjectinvasioneng
dc.subjectmetalloproteinaseseng
dc.subjectantioxidanteng
dc.subject.otherpolypodium-leucotomos extracteng
dc.subject.othernf-kappa-beng
dc.subject.othermelanoma-cellseng
dc.subject.othergene-expressioneng
dc.subject.otherdown-regulationeng
dc.subject.otherferulic acideng
dc.subject.othercancer-cellseng
dc.subject.otherantioxidanteng
dc.subject.otherapoptosiseng
dc.subject.otheralphaeng
dc.titleThe Combination of Sulforaphane and Fernblock (R) XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lineseng
dc.typearticleeng
dc.rights.holderCopyright MDPIeng
dc.identifier.doi10.3390/nu12061608
dc.identifier.pmid32486135
dc.subject.wosNutrition & Dieteticseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalSERINI, Simona:Univ Cattolica S Cuore, Sch Med, Dept Translat Med & Surg, Div Gen Pathol, Lgo F Vito 1, I-100168 Rome, Italy; Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy
hcfmusp.author.externalGUARINO, Roberta:Univ Cattolica S Cuore, Sch Med, Dept Translat Med & Surg, Div Gen Pathol, Lgo F Vito 1, I-100168 Rome, Italy
hcfmusp.author.externalCELLENO, Leonardo:Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy; Univ Cattolica S Cuore, Sch Med, Clin Dermatol, Lgo Vito 1, I-100168 Rome, Italy
hcfmusp.author.externalCALVIELLO, Gabriella:Univ Cattolica S Cuore, Sch Med, Dept Translat Med & Surg, Div Gen Pathol, Lgo F Vito 1, I-100168 Rome, Italy; Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy
hcfmusp.description.articlenumber1608
hcfmusp.description.issue6
hcfmusp.description.volume12
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000549375200001
hcfmusp.origem.id2-s2.0-85085871697
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn2072-6643
hcfmusp.citation.scopus2-
hcfmusp.scopus.lastupdate2022-06-03-
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LIM/24 - Laboratório de Oncologia Experimental

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ODS/03 - Saúde e bem-estar


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