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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSERINI, Simona
dc.contributor.authorGUARINO, Roberta
dc.contributor.authorVASCONCELOS, Renata Ottes
dc.contributor.authorCELLENO, Leonardo
dc.contributor.authorCALVIELLO, Gabriella
dc.identifier.citationNUTRIENTS, v.12, n.6, article ID 1608, 21p, 2020
dc.description.abstractPlenty of evidence supports the health effects exerted by dietary supplements containing phytochemicals, but the actual efficacy and safety of their combinations have been seldom experimentally evaluated. On this basis, we investigated in vitro the antioxidant/antineoplastic efficacy and anti-aging activity of a dietary supplement containing sulforaphane (SFN), a sulfur-isothiocyanate present in broccoli, combined with the patented extract Fernblock(R)XP (FB), obtained from the tropical fernPolypodium leucotomos. We evaluated the effect of SFN and FB, alone or in combination, on migration ability, matrix metalloproteinases (MMP) production, neoangiogenic potential and inflammasome activation in human WM115 and WM266-4 melanoma cells. Moreover, the effects on MMPs and reactive oxygen species production, and IL-1 beta secretion were studied in human normal keratinocytes. The SFN/FB combination inhibited melanoma cell migration in vitro, MMP-1, -2, -3, and -9 production, inflammasome activation and IL-1 beta secretion more efficiently than each individual compound did. In normal keratinocytes, SFN/FB was more efficient than SFN or FB alone in inhibiting MMP-1 and -3 production and IL-1 beta secretion in the presence of a pro-inflammatory stimulus such as TNF-alpha. The potential use of SFN/FB based supplements for the prevention of skin aging and as adjuvants in the treatment of advanced melanoma is suggested.eng
dc.description.sponsorshipUniversita Cattolica del S. Cuore, Rome, Italy
dc.subjectmelanoma cellseng
dc.subject.otherpolypodium-leucotomos extracteng
dc.subject.otherferulic acideng
dc.titleThe Combination of Sulforaphane and Fernblock (R) XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lineseng
dc.rights.holderCopyright MDPIeng
dc.subject.wosNutrition & Dieteticseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Simona:Univ Cattolica S Cuore, Sch Med, Dept Translat Med & Surg, Div Gen Pathol, Lgo F Vito 1, I-100168 Rome, Italy; Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy, Roberta:Univ Cattolica S Cuore, Sch Med, Dept Translat Med & Surg, Div Gen Pathol, Lgo F Vito 1, I-100168 Rome, Italy, Leonardo:Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy; Univ Cattolica S Cuore, Sch Med, Clin Dermatol, Lgo Vito 1, I-100168 Rome, Italy, Gabriella:Univ Cattolica S Cuore, Sch Med, Dept Translat Med & Surg, Div Gen Pathol, Lgo F Vito 1, I-100168 Rome, Italy; Fdn Policlin Univ A Gemelli IRCCS, Largo A Gemelli 8, I-00168 Rome, Italy
hcfmusp.relation.referenceAgren MS, 2015, EUR J CELL BIOL, V94, P12, DOI 10.1016/j.ejcb.2014.10.001eng
hcfmusp.relation.referenceAlmeida IMC, 2011, FOOD CHEM TOXICOL, V49, P3232, DOI 10.1016/j.fct.2011.09.012eng
hcfmusp.relation.referenceArcidiacono P, 2018, EUR J NUTR, V57, P2547, DOI 10.1007/s00394-017-1527-7eng
hcfmusp.relation.referenceBenedict AL, 2012, CARCINOGENESIS, V33, P2457, DOI 10.1093/carcin/bgs293eng
hcfmusp.relation.referenceChaiprasongsuk A, 2017, J PHARMACOL EXP THER, V360, P388, DOI 10.1124/jpet.116.238048eng
hcfmusp.relation.referenceChin KY, 2014, NUTRIENTS, V6, P1424, DOI 10.3390/nu6041424eng
hcfmusp.relation.referenceChung YK, 2015, J BIOSCI BIOENG, V119, P35, DOI 10.1016/j.jbiosc.2014.06.009eng
hcfmusp.relation.referenceDoss HM, 2016, LIFE SCI, V148, P201, DOI 10.1016/j.lfs.2016.02.004eng
hcfmusp.relation.referenceFasano E, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/327452eng
hcfmusp.relation.referenceFlabouraris G, 2016, J BUON, V21, P4eng
hcfmusp.relation.referenceFoucquier J, 2015, PHARMACOL RES PERSPE, V3, DOI 10.1002/prp2.149eng
hcfmusp.relation.referenceFurue M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030223eng
hcfmusp.relation.referenceGeback T, 2009, BIOTECHNIQUES, V46, P265, DOI 10.2144/000113083eng
hcfmusp.relation.referenceGhattamaneni NKR, 2018, PHARMACOL RES, V132, P99, DOI 10.1016/j.phrs.2018.04.015eng
hcfmusp.relation.referenceGianfredi V, 2017, J NUTRIGENET NUTRIGE, V10, P126, DOI 10.1159/000480636eng
hcfmusp.relation.referenceGombau L, 2006, TOXICOL IN VITRO, V20, P464, DOI 10.1016/j.tiv.2005.09.008eng
hcfmusp.relation.referenceGong YR, 2019, INT J IMMUNOPATH PH, V33, DOI 10.1177/2058738419861777eng
hcfmusp.relation.referenceGonzalez S, 2011, INT J MOL SCI, V12, P8466, DOI 10.3390/ijms12128466eng
hcfmusp.relation.referenceGreaney AJ, 2016, J LEUKOCYTE BIOL, V99, P189, DOI 10.1189/jlb.3A0415-155RReng
hcfmusp.relation.referenceHamsa TP, 2011, DRUG CHEM TOXICOL, V34, P332, DOI 10.3109/01480545.2010.538694eng
hcfmusp.relation.referenceHofmann UB, 2000, J INVEST DERMATOL, V115, P337, DOI 10.1046/j.1523-1747.2000.00068.xeng
hcfmusp.relation.referenceJaniszewska M, 2020, J BIOL CHEM, V295, P2495, DOI 10.1074/jbc.REV119.007759eng
hcfmusp.relation.referenceKelsey NA, 2010, MOLECULES, V15, P7792, DOI 10.3390/molecules15117792eng
hcfmusp.relation.referenceKim DH, 2015, INT J ONCOL, V47, P2226, DOI 10.3892/ijo.2015.3200eng
hcfmusp.relation.referenceKim M, 2015, J AGR FOOD CHEM, V63, P5428, DOI 10.1021/acs.jafc.5b00467eng
hcfmusp.relation.referenceKim SR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073877eng
hcfmusp.relation.referenceLi S, 2019, EXP ANIM TOKYO, V68, P221, DOI 10.1538/expanim.18-0146eng
hcfmusp.relation.referenceLiu F, 2012, J INVEST DERMATOL, V132, P2033, DOI 10.1038/jid.2012.119eng
hcfmusp.relation.referenceLiu P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12855-weng
hcfmusp.relation.referenceMazarakis N, 2020, CLIN NUTR, V39, P664, DOI 10.1016/j.clnu.2019.03.022eng
hcfmusp.relation.referenceMitsiogianni M, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8040106eng
hcfmusp.relation.referenceMoon DO, 2009, CANCER LETT, V274, P132, DOI 10.1016/j.canlet.2008.09.013eng
hcfmusp.relation.referenceNasri H, 2014, INT J PREVENTIVE MED, V5, P1487eng
hcfmusp.relation.referenceNeagu M, 2019, ONCOL LETT, V17, P4068, DOI 10.3892/ol.2018.9735eng
hcfmusp.relation.referenceNichols JA, 2010, ARCH DERMATOL RES, V302, P71, DOI 10.1007/s00403-009-1001-3eng
hcfmusp.relation.referenceOkamoto M, 2010, J BIOL CHEM, V285, P6477, DOI 10.1074/jbc.M109.064907eng
hcfmusp.relation.referencePanickar KS, 2015, HORM MOL BIOL CLIN I, V23, P59, DOI 10.1515/hmbci-2015-0017eng
hcfmusp.relation.referencePark KS, 2012, MOL CELLS, V34, P555, DOI 10.1007/s10059-012-0251-7eng
hcfmusp.relation.referenceParrado C, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071026eng
hcfmusp.relation.referencePeng XH, 2015, ONCOL REP, V34, P1565, DOI 10.3892/or.2015.4098eng
hcfmusp.relation.referencePhilips N, 2009, ARCH DERMATOL RES, V301, P487, DOI 10.1007/s00403-009-0950-xeng
hcfmusp.relation.referencePradhan SJ, 2010, EXP THER MED, V1, P915, DOI 10.3892/etm.2010.144eng
hcfmusp.relation.referenceRossi S, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0982-1eng
hcfmusp.relation.referenceSant?n-M?rquez R, 2019, GEROSCIENCE, V41, P655, DOI 10.1007/s11357-019-00061-7eng
hcfmusp.relation.referenceSarkar R, 2012, BIOCHEM BIOPH RES CO, V427, P80, DOI 10.1016/j.bbrc.2012.09.006eng
hcfmusp.relation.referenceSempere JM, 1997, BRIT J CLIN PHARMACO, V43, P85, DOI 10.1111/j.1365-2125.1997.tb00037.xeng
hcfmusp.relation.referenceSerini S, 2016, EXPERT OPIN THER TAR, V20, P843, DOI 10.1517/14728222.2016.1139085eng
hcfmusp.relation.referenceSerini S, 2012, CARCINOGENESIS, V33, P164, DOI 10.1093/carcin/bgr240eng
hcfmusp.relation.referenceSerini S, 2011, J NUTR BIOCHEM, V22, P874, DOI 10.1016/j.jnutbio.2010.08.004eng
hcfmusp.relation.referenceSiegel RL, 2019, CA-CANCER J CLIN, V69, P7, DOI 10.3322/caac.21551eng
hcfmusp.relation.referenceSikdar S, 2016, J COSMET DERMATOL-US, V15, P72, DOI 10.1111/jocd.12176eng
hcfmusp.relation.referenceTabrizi R, 2019, PHYTOTHER RES, V33, P253, DOI 10.1002/ptr.6226eng
hcfmusp.relation.referenceTrombino S, 2004, J AGR FOOD CHEM, V52, P2411, DOI 10.1021/jf0303924eng
hcfmusp.relation.referenceXu CJ, 2005, ONCOGENE, V24, P4486, DOI 10.1038/sj.onc.1208656eng
hcfmusp.relation.referenceYang G, 2018, RHEUMATOLOGY, V57, P727, DOI 10.1093/rheumatology/kex499eng
hcfmusp.relation.referenceYang Z, 2013, ANTIOXID REDOX SIGN, V19, P433, DOI 10.1089/ars.2012.4563eng
hcfmusp.relation.referenceYao H, 2008, INT J CANCER, V123, P1255, DOI 10.1002/ijc.23647eng
hcfmusp.relation.referenceZamarron A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082250eng
hcfmusp.relation.referenceZhu FM, 2018, CRIT REV FOOD SCI, V58, P1260, DOI 10.1080/10408398.2016.1251390eng
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Outros departamentos - FM/Outros

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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