Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/37081
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFARHAT, Luis C.
dc.contributor.authorOLFSON, Emily
dc.contributor.authorLEVINE, Jessica L. S.
dc.contributor.authorLI, Fenghua
dc.contributor.authorFRANKLIN, Martin E.
dc.contributor.authorLEE, Han-Joo
dc.contributor.authorLEWIN, Adam B.
dc.contributor.authorMCGUIRE, Joseph F.
dc.contributor.authorRAHMAN, Omar
dc.contributor.authorSTORCH, Eric A.
dc.contributor.authorTOLIN, David F.
dc.contributor.authorZICKGRAF, Hana F.
dc.contributor.authorBLOCH, Michael H.
dc.date.accessioned2020-08-20T13:26:20Z-
dc.date.available2020-08-20T13:26:20Z-
dc.date.issued2020
dc.identifier.citationJOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, v.30, n.5, p.306-315, 2020
dc.identifier.issn1044-5463
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37081-
dc.description.abstractObjectives: In clinical trials of pediatric trichotillomania (TTM), three instruments are typically employed to rate TTM severity: (1) the Massachusetts General Hospital Hair Pulling Scale (MGH-HPS), (2) the National Institute of Mental Health Trichotillomania Severity Scale (NIMH-TSS), and (3) the Trichotillomania Scale for Children (TSC). These instruments lack standardized definitions of treatment response, which lead researchers to determine their own definitions of response post hoc and potentially inflate results. We performed a meta-analysis to provide empirically determined accuracy measures for percentage reduction cut points in these three instruments. Methods: MEDLINE was searched for TTM clinical trials. A total of 67 studies were initially identified, but only 5 were clinical trials focused on TTM in pediatric populations and therefore were included in this meta-analysis (n = 180). A Clinical Global Impressions Improvement score <= 2 was used to define clinical response. Receiver operating characteristic principles were employed to determine accuracy measures for percentage reduction cut points on each one of the instruments. Meta-DiSc software was employed to provide pooled accuracy measures for each cut point for each instrument. The Youden Index and the distance to corner methods were used to determine the optimal cut point. Results: The optimal cut points to determine treatment response were a 45% reduction on the MGH-HPS (Youden Index 0.40, distance to corner 0.20), a 35% reduction on the NIMH-TSS (Youden Index 0.42, distance to corner 0.17), a 25% reduction on the TSC child version (TSC-C; Youden Index 0.40, distance to corner 0.18), and a 45% (distance to corner 0.30) or 50% reduction (Youden Index 0.33) on the TSC parent version (TSC-P). The TSC-C had less discriminative ability at determining response in younger children in comparison to older children; no age-related differences were observed on the TSC-P. Conclusions: This study provides empirically determined cut points of treatment response on three instruments that rate TTM severity. These data-driven cut points will benefit future research on pediatric TTM.eng
dc.description.sponsorshipNIMH NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R25 MH077823]
dc.language.isoeng
dc.publisherMARY ANN LIEBERT, INCeng
dc.relation.ispartofJournal of Child and Adolescent Psychopharmacology
dc.rightsrestrictedAccesseng
dc.subjecttrichotillomaniaeng
dc.subjectchildren and adolescentseng
dc.subjectclinical trialseng
dc.subjectmeta-analysiseng
dc.subjectMassachusetts General Hospital Hair Pulling Scale (MGH-HPS)eng
dc.subjectNational Institute of Mental Health Trichotillomania Severity Scale (NIMH-TSS)eng
dc.subjectTrichotillomania Scale for Children (TSC)eng
dc.subject.otherfunctional impairmenteng
dc.subject.otherdescriptive psychopathologyeng
dc.subject.othertreating trichotillomaniaeng
dc.subject.otherbehavior-therapyeng
dc.subject.otherchildreneng
dc.subject.otheranxietyeng
dc.subject.otherscaleeng
dc.titleMeasuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trialseng
dc.typearticleeng
dc.rights.holderCopyright MARY ANN LIEBERT, INCeng
dc.identifier.doi10.1089/cap.2019.0103
dc.identifier.pmid31794677
dc.subject.wosPediatricseng
dc.subject.wosPharmacology & Pharmacyeng
dc.subject.wosPsychiatryeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalOLFSON, Emily:Yale Univ, Dept Psychiat, New Haven, CT 06520 USA; Yale Child Study Ctr, POB 207900, New Haven, CT 06520 USA
hcfmusp.author.externalLEVINE, Jessica L. S.:Yale Child Study Ctr, POB 207900, New Haven, CT 06520 USA
hcfmusp.author.externalLI, Fenghua:Yale Child Study Ctr, POB 207900, New Haven, CT 06520 USA
hcfmusp.author.externalFRANKLIN, Martin E.:Univ Penn, Dept Psychiat, Perelman Sch Med, Child & Adolescent OCD Tic Trich & Anxiety Grp CO, Philadelphia, PA 19104 USA
hcfmusp.author.externalLEE, Han-Joo:Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA
hcfmusp.author.externalLEWIN, Adam B.:Univ S Florida, Dept Pediat, Tampa, FL 33620 USA
hcfmusp.author.externalMCGUIRE, Joseph F.:Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
hcfmusp.author.externalRAHMAN, Omar:Univ S Florida, Dept Pediat, Tampa, FL 33620 USA
hcfmusp.author.externalSTORCH, Eric A.:Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
hcfmusp.author.externalTOLIN, David F.:Inst Living, Hartford, CT USA; Yale Univ, Sch Med, New Haven, CT USA
hcfmusp.author.externalZICKGRAF, Hana F.:Univ Penn, Dept Psychiat, Perelman Sch Med, Child & Adolescent OCD Tic Trich & Anxiety Grp CO, Philadelphia, PA 19104 USA; Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA
hcfmusp.author.externalBLOCH, Michael H.:Yale Univ, Dept Psychiat, New Haven, CT 06520 USA; Yale Child Study Ctr, POB 207900, New Haven, CT 06520 USA
hcfmusp.description.beginpage306
hcfmusp.description.endpage315
hcfmusp.description.issue5
hcfmusp.description.volume30
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000500490700001
hcfmusp.origem.id2-s2.0-85084419020
hcfmusp.publisher.cityNEW ROCHELLEeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAmerican Psychiatric Association, 2013, DIAGN STAT MAN MENTeng
hcfmusp.relation.referenceBloch MH, 2007, BIOL PSYCHIAT, V62, P839, DOI 10.1016/j.biopsych.2007.05.019eng
hcfmusp.relation.referenceBloch MH, 2013, J AM ACAD CHILD PSY, V52, P231, DOI 10.1016/j.jaac.2012.12.020eng
hcfmusp.relation.referenceBloch MH, 2009, J AM ACAD CHILD PSY, V48, P879, DOI 10.1097/CHI.0b013e3181ae09f3eng
hcfmusp.relation.referenceBusner Joan, 2007, Psychiatry (Edgmont), V4, P28eng
hcfmusp.relation.referenceCHRISTENSON GA, 1991, AM J PSYCHIAT, V148, P365eng
hcfmusp.relation.referenceCHRISTENSON GA, 1991, J CLIN PSYCHIAT, V52, P415eng
hcfmusp.relation.referenceDiefenbach GJ, 2002, BEHAV RES THER, V40, P1305, DOI 10.1016/S0005-7967(02)00006-2eng
hcfmusp.relation.referenceEmsley R, 2009, WORLD PSYCHIATRY, V8, P33eng
hcfmusp.relation.referenceFarhat LC, 2019, PROG NEURO-PSYCHOPH, V89, P446, DOI 10.1016/j.pnpbp.2018.10.009eng
hcfmusp.relation.referenceFleischhacker WW, 2009, WORLD PSYCHIATRY, V8, P23eng
hcfmusp.relation.referenceFlessner CA, 2007, BEHAV MODIF, V31, P896, DOI 10.1177/0145445507302521eng
hcfmusp.relation.referenceFranklin ME, 2011, J AM ACAD CHILD PSY, V50, P763, DOI 10.1016/j.jaac.2011.05.009eng
hcfmusp.relation.referenceFranklin ME, 2008, J DEV BEHAV PEDIATR, V29, P493, DOI 10.1097/DBP.0b013e31818d4328eng
hcfmusp.relation.referenceHoughton DC, 2015, J ANXIETY DISORD, V36, P44, DOI 10.1016/j.janxdis.2015.09.008eng
hcfmusp.relation.referenceJACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037/0022-006X.59.1.12eng
hcfmusp.relation.referenceKeuthen NJ, 2008, CHILD FAM BEHAV THER, V30, P337, DOI 10.1080/07317100802483215eng
hcfmusp.relation.referenceKraemer HC, 2006, BIOL PSYCHIAT, V59, P990, DOI 10.1016/j.biopsych.2005.09.014eng
hcfmusp.relation.referenceLee HJ, 2018, PSYCHIAT RES, V262, P20, DOI 10.1016/j.psychres.2017.12.070eng
hcfmusp.relation.referenceLewin AB, 2009, DEPRESS ANXIETY, V26, P521, DOI 10.1002/da.20537eng
hcfmusp.relation.referenceMcGuire JF, 2014, J PSYCHIATR RES, V58, P76, DOI 10.1016/j.jpsychires.2014.07.015eng
hcfmusp.relation.referenceMcGuire JF, 2012, CHILD PSYCHIAT HUM D, V43, P855, DOI 10.1007/s10578-012-0300-7eng
hcfmusp.relation.referenceOdlaug Brian L, 2010, Prim Care Companion J Clin Psychiatry, V12, DOI 10.4088/PCC.09m00842whieng
hcfmusp.relation.referencePanza KE, 2013, J AM ACAD CHILD PSY, V52, P241, DOI 10.1016/j.jaac.2012.12.019eng
hcfmusp.relation.referenceRahman O, 2017, J CHILD ADOL PSYCHOP, V27, P132, DOI 10.1089/cap.2016.0085eng
hcfmusp.relation.referenceTolin David F., 2007, Cognitive Behaviour Therapy, V36, P129, DOI 10.1080/16506070701223230eng
hcfmusp.relation.referenceTolin DF, 2008, CHILD PSYCHIAT HUM D, V39, P331, DOI 10.1007/s10578-007-0092-3eng
hcfmusp.relation.referenceUnal I, 2017, COMPUT MATH METHOD M, DOI 10.1155/2017/3762651eng
hcfmusp.relation.referenceWoods DW, 2006, PSYCHIAT CLIN N AM, V29, P487, DOI 10.1016/j.psc.2006.02.009eng
hcfmusp.relation.referenceZamora Javier, 2006, BMC Med Res Methodol, V6, P31, DOI 10.1186/1471-2288-6-31eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1557-8992
hcfmusp.citation.scopus2-
hcfmusp.scopus.lastupdate2022-04-29-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/Outros
Outros departamentos - FM/Outros

Artigos e Materiais de Revistas Científicas - LIM/21
LIM/21 - Laboratório de Neuroimagem em Psiquiatria


Files in This Item:
File Description SizeFormat 
art_FARHAT_Measuring_Treatment_Response_in_Pediatric_Trichotillomania_A_MetaAnalysis_2020.PDF
  Restricted Access
publishedVersion (English)330.49 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.