LIM/29 - Laboratório de Nefrologia Celular, Genética e Molecular

O Laboratório de Nefrologia Celular, Genética e Molecular é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: patogênese molecular e celular da doença renal policística autossômica recessiva; células-tronco e doenças renais; mecanismos inflamatórios envolvidos na fibrogênese das doenças renais e análise de estratégias antifibróticas; e mecanismos envolvidos na rejeição e tolerância ao enxerto em transplante de órgãos: rim, pâncreas e transplante experimental de rim e ilhotas pancreáticas.

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Recent Submissions

  1. Temporal Reduction in COVID-19-Associated Fatality Among Kidney Transplant Recipients: The Brazilian COVID-19 Registry Cohort Study

    TRANSPLANT INTERNATIONAL, v.36, article ID 10205, 11p, 2022

    Data from the general population suggest that fatality rates declined during the course of the pandemic. This analysis, using data extracted from the Brazilian Kidney Transplant COVID-19 Registry, seeks to determine fatality rates over time since the index case on March 3rd, 2020. Data from hospi...

  2. Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.7, article ID 3842, 20p, 2022

    Diabetes mellitus (DM) burden encompasses diabetic kidney disease (DKD), the leading cause of end-stage renal disease worldwide. Despite compelling evidence indicating that pharmacological intervention curtails DKD progression, the search for non-pharmacological strategies can identify novel targ...

  3. Disruption of polycystin-1 cleavage leads to cardiac metabolic rewiring in mice

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v.1868, n.6, article ID 166371, 17p, 2022

    Cardiovascular manifestations account for marked morbi-mortality in autosomal dominant polycystic kidney disease (ADPKD). Pkd1- and Pkd2-deficient mice develop cardiac dysfunction, however the underlying mechanisms remain largely unclear. It is unknown whether impairment of polycystin-1 cleavage ...

  4. The Symbiotic Effect of a New Nutraceutical with Yeast beta-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1 alpha, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model

    ANTIOXIDANTS, v.11, n.3, article ID 447, 24p, 2022

    The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the follow...

  5. The Dermatophyte Trichophyton rubrum Induces Neutrophil Extracellular Traps Release by Human Neutrophils

    JOURNAL OF FUNGI, v.8, n.2, article ID 147, 9p, 2022

    Neutrophils are the first leukocytes recruited to the site of infection and are thought to be responsible for fungal elimination from the skin such as dermatophytes. Neutrophils are able to secrete reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) that can kill different fun...

  6. Collapsing glomerulopathy following SARS-CoV-2 adenovirus-vector-based vaccine: report of 2 cases

    KIDNEY INTERNATIONAL, v.101, n.3, p.637-+, 2022

  7. Evaluation of central venous catheter and other risk factors for mortality in chronic hemodialysis patients with COVID-19 in Brazil

    INTERNATIONAL UROLOGY AND NEPHROLOGY, v.54, n.1, p.193-199, 2022

    Purpose Hemodialysis patients with COVID-19 are at increased risk of death. We aimed to describe the characteristics of a cohort of Brazilian hemodialysis patients with COVID-19 and assess their mortality rate and risk factors for death. Methods Retrospective cohort study of 741 Brazilian hemodia...

  8. Acute kidney injury in a mouse model of meningococcal disease

    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, v.35, article ID 20587384211056507, 10p, 2021

    Introduction Meningococcal disease is associated with high mortality. When acute kidney injury (AKI) occurs in patients with severe meningococcal disease, it is typically attributable to sepsis, although meningococcal disease and lipopolysaccharide release are rarely investigated. Therefore, we e...

  9. Distal Renal Tubular Acidosis Associated with Autoimmune Diseases: Reports of 3 Cases and Review of Mechanisms


    Objective: Unusual clinical course Background: Distal renal tubular acidosis (dRTA) is a defect in the urinary acidification process that limits the elimination of protons [H+] by alpha intercalated cells in the collecting tubules, with consequent metabolic acidosis with a normal plasma anion gap...

  10. Thromboprophylaxis after kidney transplantation in children: Ten-year experience of a single Brazilian center

    PEDIATRIC TRANSPLANTATION, v.25, n.8, article ID e14101, 8p, 2021

    Background Kidney transplantation is the gold standard treatment for children with end-stage chronic kidney disease. Graft thrombosis is an important cause of graft failure, with high morbidity, mortality, and impact on quality of life and to the health system. The role of thromboprophylaxis in t...