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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPALMIER, Natalia Rangel
dc.contributor.authorMIGLIORATI, Cesar Augusto
dc.contributor.authorPRADO-RIBEIRO, Ana Carolina
dc.contributor.authorOLIVEIRA, Maria Cecilia Querido de
dc.contributor.authorVECHIATO FILHO, Aljomar Jose
dc.contributor.authorGOES, Mario Fernando de
dc.contributor.authorBRANDAO, Thais Bianca
dc.contributor.authorLOPES, Marcio Ajudarte
dc.contributor.authorSANTOS-SILVA, Alan Roger
dc.identifier.citationORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v.130, n.1, p.52-62, 2020
dc.description.abstractObjective and study design. This narrative review summarizes the current state of art of radiation-related caries (RC), an aggressive disease that affects approximately 30% of post-head and neck radiotherapy (HNRT) patients. Results. RC mainly affects the tooth cervical areas and incisal/cuspal tips and develops 6 to 12 months after HNRT. Early RC signs include black/brownish tooth discoloration and enamel cracks, which progress to enamel delamination, exposing underlying dentin to a highly cariogenic oral environment and rapid tooth destruction/dental crown amputation. As RC advances and renders the tooth nonrestorable, it may lead to osteoradionecrosis spontaneously or upon extraction if the tooth is in a highly irradiated field of the oral cavity. This requires aggressive treatment, which would have a negative impact on a cancer survivor's quality of life and contribute to the incremental cost of cancer care. Chlorhexidine mouth rinses and topical fluoride applications are effective agents used in RC prevention; however, there are no well-established treatment protocols. Once RC progresses, dental restorations should be performed with adhesive materials in association with systematic fluoride application as illustrated in the clinical case presented in this review. Post-HNRT patients should be closely followed up for optimal RC prevention, early diagnosis, and prompt treatment. Conclusions. Future clinical studies are necessary to establish a contemporary, clinically validated protocol for RC management.eng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/04657-8, 2018/02233-6, 2016/22862-2, 2013/18402-8, 2012/06138-1]
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq), BrazilNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), BrazilCAPES [001]
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.subject.otherresin composite restorationseng
dc.subject.othersymptom clusterseng
dc.subject.otherxerostomic headeng
dc.subject.otherdental diseaseeng
dc.subject.otherpulp vitalityeng
dc.titleRadiation-related caries: current diagnostic, prognostic, and management paradigmseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Natalia Rangel:Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag, Piracicaba, SP, Brazil, Cesar Augusto:Univ Florida, Coll Dent, Gainesville, FL USA, Mario Fernando de:Univ Estadual Campinas, Restorat Dent Dept, Piracicaba Dent Sch, Piracicaba, SP, Brazil, Marcio Ajudarte:Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag, Piracicaba, SP, Brazil, Alan Roger:Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag, Piracicaba, SP, Brazil
hcfmusp.publisher.cityNEW YORKeng
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Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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