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Title: Cognitive assessment in patients with Hepatitis C submitted to treatment with Sofosbuvir and Simeprevir or Daclatasvir
Authors: GASCON, Maria Rita PoloBENUTE, Glaucia Rosana GuerraMACEDO, Elizeu CoutinhoCAPITAO, Claudio GarciaVIDAL, Jose ErnestoSMID, JerusaMARCUSSO, Rosa Maria NascimentoLUCIA, Mara Cristina Souza dePENALVA-DE-OLIVEIRA, Augusto CesarDIAMENT, Decio
Citation: ARQUIVOS DE NEURO-PSIQUIATRIA, v.78, n.6, p.342-348, 2020
Abstract: Background:Hepatitis C can be defined as an infectious disease that develops an inflammatory activity, which may cause an impairment in the central nervous system, may cause cognitive impairments and symptoms of depression.Objective:The objective of this study was to verify the cognitive performance of patients with chronic hepatitis C before and after treatment with simeprevir, sofosbuvir, and daclatasvir. Methods:A prospective study was carried out in three stages: before, right after treatment, and six months after. Fifty-eight patients under clinical follow-up were evaluated at the Emilio Ribas Infectology Institute, in Sao Paulo, Brazil. The following instruments were used: sociodemographic questionnaire, Lawton's Scale, Beck's Depression Inventory, and a battery of neuropsychological tests that evaluated: intellectual function, memory, attention, executive function, and motor and processing speed). For statistical analysis, the analyses described (mean, frequency, and standard deviation), chi-square, and ANOVA were used. Results:Most of the participants were male (n=30, 51.7%), with a mean of 58.23 +/- 8.79 years, mean schooling of 9.75 +/- 4.43 years. Comparing the results of neuropsychological evaluations (before, just after completion of drugs, and six months), a significant improvement was observed in relation to the acquisition of new knowledge (p=0.03), late visual memory (p=0.01), and tendency towards alternate attention (p=0.07). Conclusion:The treatment of the hepatitis C virus improved cognitive performance, especially in relation to memory.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/49
LIM/49 - Laboratório de Protozoologia

Artigos e Materiais de Revistas Científicas - LIM/57
LIM/57 - Laboratório de Fisiologia Obstétrica

Artigos e Materiais de Revistas Científicas - ODS/03

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