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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | CAMPOS, Luciana Aparecida | |
dc.contributor.author | BUENO, Clarissa | |
dc.contributor.author | BARCELOS, Isabella P. | |
dc.contributor.author | HALPERN, Bruno | |
dc.contributor.author | BRITO, Leandro C. | |
dc.contributor.author | AMARAL, Fernanda G. | |
dc.contributor.author | BALTATU, Ovidiu Constantin | |
dc.contributor.author | CIPOLLA-NETO, Jose | |
dc.date.accessioned | 2020-08-20T13:27:43Z | - |
dc.date.available | 2020-08-20T13:27:43Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | FRONTIERS IN ENDOCRINOLOGY, v.11, article ID 239, 8p, 2020 | |
dc.identifier.issn | 1664-2392 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/37173 | - |
dc.description.abstract | The purpose of this investigational study was to assess the effects of melatonin replacement therapy on cardiac autonomic modulation in pinealectomized patients. This was an open-label, single-arm, single-center, proof-of-concept study consisting of a screening period, a 3-month treatment period with melatonin (3 mg/day), and a 6-month washout period. The cardiac autonomic function was determined through heart rate variability (HRV) measures during polysomnography. Pinealectomized patients (n = 5) with confirmed absence of melatonin were included in this study. Melatonin treatment increased vagal-dominated HRV indices including root mean square of the successive R-R interval differences (RMSSD) (39.7 ms, 95% CI 2.0-77.4, p = 0.04), percentage of successive R-R intervals that differ by more than 50 ms (pNN50) (17.1%, 95% CI 9.1-25.1, p = 0.003), absolute power of the high-frequency band (HF power) (1,390 ms(2), 95% CI 511.9-2,267, p = 0.01), and sympathetic HRV indices like standard deviation of normal R-R wave interval (SDNN) (57.6 ms, 95% CI 15.2-100.0, p = 0.02), and absolute power of the low-frequency band (LF power) (4,592 ms(2), 95% CI 895.6-8,288, p = 0.03). These HRV indices returned to pretreatment values when melatonin treatment was discontinued. The HRV entropy-based regularity parameters were not altered in this study, suggesting that there were no significant alterations of the REM-NREM ratios between the time stages of the study. These data show that 3 months of melatonin treatment may induce an improvement in cardiac autonomic modulation in melatonin-non-proficient patients. ClinicalTrials.gov Identifier: NCT03885258. | eng |
dc.description.sponsorship | Sao Paulo Research FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2014/50457-0] | |
dc.description.sponsorship | Khalifa University of Science and Technology [FSU-2020-33] | |
dc.description.sponsorship | National Council for Scientific and Technological Development (CNPq)National Council for Scientific and Technological Development (CNPq) [307760/2018-9, 301324/2018-22] | |
dc.language.iso | eng | |
dc.publisher | FRONTIERS MEDIA SA | eng |
dc.relation.ispartof | Frontiers in Endocrinology | |
dc.rights | openAccess | eng |
dc.subject | melatonin | eng |
dc.subject | therapeutics | eng |
dc.subject | pinealectomy | eng |
dc.subject | pineal tumor | eng |
dc.subject | heart rate variability | eng |
dc.subject.other | heart-rate-variability | eng |
dc.subject.other | blood-pressure | eng |
dc.subject.other | time-domain | eng |
dc.subject.other | sleep | eng |
dc.subject.other | receptors | eng |
dc.title | Melatonin Therapy Improves Cardiac Autonomic Modulation in Pinealectomized Patients | eng |
dc.type | article | eng |
dc.rights.holder | Copyright FRONTIERS MEDIA SA | eng |
dc.identifier.doi | 10.3389/fendo.2020.00239 | |
dc.identifier.pmid | 32431667 | |
dc.subject.wos | Endocrinology & Metabolism | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | CAMPOS, Luciana Aparecida:Sao Jose dos Campos Technol Pk, CITE, Sao Paulo, Brazil; Anhembi Morumbi Univ, Laureate Int Univ, Inst Biomed Engn, Sao Jose Dos Campos, Brazil; Abu Dhabi Univ, Coll Hlth Sci, Abu Dhabi, U Arab Emirates | |
hcfmusp.author.external | BARCELOS, Isabella P.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil | |
hcfmusp.author.external | BRITO, Leandro C.:Univ Sao Paulo, Sch Phys Educ & Sport, Exercise Hemodynam Lab, Sao Paulo, Brazil | |
hcfmusp.author.external | AMARAL, Fernanda G.:Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil | |
hcfmusp.author.external | BALTATU, Ovidiu Constantin:Sao Jose dos Campos Technol Pk, CITE, Sao Paulo, Brazil; Anhembi Morumbi Univ, Laureate Int Univ, Inst Biomed Engn, Sao Jose Dos Campos, Brazil; Khalifa Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Abu Dhabi, U Arab Emirates | |
hcfmusp.author.external | CIPOLLA-NETO, Jose:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil | |
hcfmusp.description.articlenumber | 239 | |
hcfmusp.description.volume | 11 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000536060100001 | |
hcfmusp.origem.id | 2-s2.0-85085083503 | |
hcfmusp.publisher.city | LAUSANNE | eng |
hcfmusp.publisher.country | SWITZERLAND | eng |
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dc.description.index | PubMed | eng |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/63 Artigos e Materiais de Revistas Científicas - ODS/03 |
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