Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/37197
Title: The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort
Authors: RADIN, MassimoSCIASCIA, SavinoERKAN, DorukPENGO, VittorioTEKTONIDOU, Maria G.UGARTE, AmaiaMERONI, PierluigiJI, LanlanBELMONT, H. MichaelCOHEN, HannahJESUS, Guilherme Ramires deBRANCH, D. WareFORTIN, Paul R.ANDREOLI, LauraPETRI, MichelleRODRIGUEZ, EstherRODRIGUEZ-PINTO, IgnasiKNIGHT, Jason S.ATSUMI, TatsuyaWILLIS, RohanGONZALEZ, EmilioLOPEZ-PEDRERA, RosarioGANDARA, Ana Paula RossiVENDRAMINI, Margarete Borges GualhardoBANZATO, AlessandraSEVIM, EcemBARBHAIYA, MedhaEFTHYMIOU, MariaMACKIE, IanBERTOLACCINI, Maria LauraANDRADE, DanieliPONS-ESTEL, GuillermoGIANNAKOPOULOS, BillKRILIS, SteveJESUS, Guilherme deLEVY, RogerUGOLINI-LOPES, MichelleROSA, RenataANDRADE, DanieliFORTIN, Paul F.ZHANG, ZhouliZUILY, StephaneWAHL, DenisTEKTONIDOU, MariaNALLI, CeciliaANDREOLI, LauraTINCANI, AngelaCHIGHIZOLA, Cecilia B.GEROSA, MariaMERONI, PierluigiBANZATO, AlessandroPENGO, VittorioSCIASCIA, SavinoCEULAER, Karel DeDAVIS, StacyAMENGUAL, OlgaATSUMI, TatsuyaUTHMAN, ImadLIMPER, MaartenDERKSEN, RonaldGROOT, Philip deUGARTE, AmaiaIRASTORZA, Guillermo RuizRODRIGUEZ-PINTO, IgnasiCERVERA, RicardRODRIGUEZ, EstherCUADRADO, MariaZAMORANO, Maria Angeles AguirreLOPEZ-PEDRERA, RosarioARTIM-ESEN, BaharINANC, MuratMACKIE, IanEFTHYMIOU, MariaCOHEN, HannahBERTOLACCINI, Maria LauraKHAMASHTA, MuntherSANNA, GiovanniKNIGHT, Jason S.PETRI, MichelleROUBEY, RobertORTEL, TomGONZALEZ, EmilioWILLIS, RohanLEVINE, StevenRAND, JacobBELMONT, H. MichaelBARBHAIYA, MedhaERKAN, DorukSALMON, JaneLOCKSHIN, MichaelBRANCH, Ware
Citation: SEMINARS IN ARTHRITIS AND RHEUMATISM, v.49, n.3, p.464-468, 2019
Abstract: Objectives: To assess whether patients with antiphospholipid syndrome (APS) and history of recurrent thrombosis have higher levels of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) when compared to patients without recurrent thrombosis. Methods: In this cross-sectional study of antiphospholipid antibody (aPL)-positive patients, we identified APS patients with a history of documented thrombosis from the AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (""Registry""). Data on aPL-related medical history and cardiovascular risk factors were retrospectively collected. The aGAPSS was calculated at Registry entry by adding the points corresponding to the risk factors: three for hyperlipidemia, one for arterial hypertension, five for positive anticardiolipin antibodies, four for positive anti-beta(2) glycoprotein-1 antibodies and four for positive lupus anticoagulant test. Results: The analysis included 379 APS patients who presented with arterial and/or venous thrombosis. Overall, significantly higher aGAPSS were seen in patients with recurrent thrombosis (arterial or venous) compared to those without recurrence (7.8 +/- 3.3 vs. 6 +/- 3.9, p<0.05). When analyzed based on the site of the recurrence, patients with recurrent arterial, but not venous, thrombosis had higher aGAPSS (8.1 +/- SD 2.9 vs. 6 +/- 3.9; p<0.05). Conclusions: Based on analysis of our international large-scale Registry of aPL-positive patients, the aGAPSS might help risk stratifying patients based on the likelihood of developing recurrent thrombosis in APS.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia


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