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https://observatorio.fm.usp.br/handle/OPI/37197
Título: | The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort |
Autor: | RADIN, Massimo; SCIASCIA, Savino; ERKAN, Doruk; PENGO, Vittorio; TEKTONIDOU, Maria G.; UGARTE, Amaia; MERONI, Pierluigi; JI, Lanlan; BELMONT, H. Michael; COHEN, Hannah; JESUS, Guilherme Ramires de; BRANCH, D. Ware; FORTIN, Paul R.; ANDREOLI, Laura; PETRI, Michelle; RODRIGUEZ, Esther; RODRIGUEZ-PINTO, Ignasi; KNIGHT, Jason S.; ATSUMI, Tatsuya; WILLIS, Rohan; GONZALEZ, Emilio; LOPEZ-PEDRERA, Rosario; GANDARA, Ana Paula Rossi; VENDRAMINI, Margarete Borges Gualhardo; BANZATO, Alessandra; SEVIM, Ecem; BARBHAIYA, Medha; EFTHYMIOU, Maria; MACKIE, Ian; BERTOLACCINI, Maria Laura; ANDRADE, Danieli; PONS-ESTEL, Guillermo; GIANNAKOPOULOS, Bill; KRILIS, Steve; JESUS, Guilherme de; LEVY, Roger; UGOLINI-LOPES, Michelle; ROSA, Renata; ANDRADE, Danieli; FORTIN, Paul F.; ZHANG, Zhouli; ZUILY, Stephane; WAHL, Denis; TEKTONIDOU, Maria; NALLI, Cecilia; ANDREOLI, Laura; TINCANI, Angela; CHIGHIZOLA, Cecilia B.; GEROSA, Maria; MERONI, Pierluigi; BANZATO, Alessandro; PENGO, Vittorio; SCIASCIA, Savino; CEULAER, Karel De; DAVIS, Stacy; AMENGUAL, Olga; ATSUMI, Tatsuya; UTHMAN, Imad; LIMPER, Maarten; DERKSEN, Ronald; GROOT, Philip de; UGARTE, Amaia; IRASTORZA, Guillermo Ruiz; RODRIGUEZ-PINTO, Ignasi; CERVERA, Ricard; RODRIGUEZ, Esther; CUADRADO, Maria; ZAMORANO, Maria Angeles Aguirre; LOPEZ-PEDRERA, Rosario; ARTIM-ESEN, Bahar; INANC, Murat; MACKIE, Ian; EFTHYMIOU, Maria; COHEN, Hannah; BERTOLACCINI, Maria Laura; KHAMASHTA, Munther; SANNA, Giovanni; KNIGHT, Jason S.; PETRI, Michelle; ROUBEY, Robert; ORTEL, Tom; GONZALEZ, Emilio; WILLIS, Rohan; LEVINE, Steven; RAND, Jacob; BELMONT, H. Michael; BARBHAIYA, Medha; ERKAN, Doruk; SALMON, Jane; LOCKSHIN, Michael; BRANCH, Ware |
Citación: | SEMINARS IN ARTHRITIS AND RHEUMATISM, v.49, n.3, p.464-468, 2019 |
Resumen: | Objectives: To assess whether patients with antiphospholipid syndrome (APS) and history of recurrent thrombosis have higher levels of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) when compared to patients without recurrent thrombosis. Methods: In this cross-sectional study of antiphospholipid antibody (aPL)-positive patients, we identified APS patients with a history of documented thrombosis from the AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (""Registry""). Data on aPL-related medical history and cardiovascular risk factors were retrospectively collected. The aGAPSS was calculated at Registry entry by adding the points corresponding to the risk factors: three for hyperlipidemia, one for arterial hypertension, five for positive anticardiolipin antibodies, four for positive anti-beta(2) glycoprotein-1 antibodies and four for positive lupus anticoagulant test. Results: The analysis included 379 APS patients who presented with arterial and/or venous thrombosis. Overall, significantly higher aGAPSS were seen in patients with recurrent thrombosis (arterial or venous) compared to those without recurrence (7.8 +/- 3.3 vs. 6 +/- 3.9, p<0.05). When analyzed based on the site of the recurrence, patients with recurrent arterial, but not venous, thrombosis had higher aGAPSS (8.1 +/- SD 2.9 vs. 6 +/- 3.9; p<0.05). Conclusions: Based on analysis of our international large-scale Registry of aPL-positive patients, the aGAPSS might help risk stratifying patients based on the likelihood of developing recurrent thrombosis in APS. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/17 |
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