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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorUNLU, Ozan
dc.contributor.authorERKAN, Doruk
dc.contributor.authorBARBHAIYA, Medha
dc.contributor.authorANDRADE, Danieli
dc.contributor.authorNASCIMENTO, Iana
dc.contributor.authorROSA, Renata
dc.contributor.authorBANZATO, Alessandra
dc.contributor.authorPENGO, Vittorio
dc.contributor.authorUGARTE, Amaia
dc.contributor.authorGEROSA, Maria
dc.contributor.authorJI, Lanlan
dc.contributor.authorEFTHYMIOU, Maria
dc.contributor.authorBRANCH, D. Ware
dc.contributor.authorJESUS, Guilherme Ramires de
dc.contributor.authorTINCANI, Angela
dc.contributor.authorBELMONT, H. Michael
dc.contributor.authorFORTIN, Paul R.
dc.contributor.authorPETRI, Michelle
dc.contributor.authorRODRIGUEZ, Esther
dc.contributor.authorPONS-ESTEL, Guillermo J.
dc.contributor.authorKNIGHT, Jason S.
dc.contributor.authorATSUMI, Tatsuya
dc.contributor.authorWILLIS, Rohan
dc.contributor.authorZUILY, Stephane
dc.contributor.authorTEKTONIDOU, Maria G.
dc.identifier.citationARTHRITIS CARE & RESEARCH, v.71, n.1, p.134-141, 2019
dc.description.abstractObjective Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist regarding the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective of this study was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with SLE with those of aPL-positive patients without SLE. Methods A secure web-based data capture system was used to store patient demographic characteristics and aPL-related clinical and laboratory characteristics. Inclusion criteria included positive aPL according to the updated Sapporo classification criteria. Antiphospholipid antibody-positive patients fulfilling the American College of Rheumatology criteria for the classification of SLE (""aPL with SLE"") and those with no other autoimmune diseases (""aPL only"") were included in the analysis. Results Six hundred seventy-two aPL-positive patients were recruited from 24 international centers; 426 of these patients did not have other autoimmune disease, and 197 had SLE. The frequency of thrombocytopenia, hemolytic anemia, low complement levels, and IgA anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies was higher in the aPL-positive patients with SLE, whereas the frequency of cognitive dysfunction and IgG anti-beta(2)GPI antibodies was higher in the aPL-only group. The frequency of arterial and venous thromboses (including recurrent) as well as pregnancy morbidity was similar in the 2 groups. The prevalence of cardiovascular disease risk factors at the time of entry into the registry entry did not differ between the 2 groups, with the exception of current smoking, which was more frequent in aPL-positive patients with SLE. Conclusion Although the frequencies of thrombosis and pregnancy morbidity are similar in aPL-positive patients with and those without SLE, the diagnosis of SLE in patients with persistently positive aPL is associated with an increased frequency of thrombocytopenia, hemolytic anemia, low complement levels, and positive IgA anti-beta(2)GPI antibodies.eng
dc.description.sponsorshipNew York Community Trust
dc.description.sponsorshipClinical and Translational Science Center at Weill Cornell Medicine [UL1-TR000457]
dc.relation.ispartofArthritis Care & Research
dc.subject.otherclassification criteriaeng
dc.subject.otherconsensus statementeng
dc.titleThe Impact of Systemic Lupus Erythematosus on the Clinical Phenotype of Antiphospholipid Antibody-Positive Patients: Results From the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Clinical Database and Repositoryeng
dc.rights.holderCopyright WILEYeng
dc.contributor.groupauthorAntiPhospholipid Syndrome All
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Ozan:Weill Cornell Med, New York, NY USA, Doruk:Weill Cornell Med, New York, NY USA, Medha:Weill Cornell Med, New York, NY USA, Alessandra:Univ Hosp Padova, Padua, Italy, Vittorio:Univ Hosp Padova, Padua, Italy, Amaia:Hosp Univ Cruces Bizkaia, Baracaldo, Spain, Maria:Univ Milan, Milan, Italy, Lanlan:Peking Univ, Hosp 1, Beijing, Peoples R China, Maria:UCL, London, England, D. Ware:Univ Utah, Salt Lake City, UT USA; Intermt Healthcare, Salt Lake City, UT USA, Guilherme Ramires de:Univ Estado Rio De Janeiro, Rio De Janeiro, Brazil, Angela:Univ Brescia, Brescia, Italy, H. Michael:NYU, Sch Med, Langone Med Ctr, New York, NY USA, Paul R.:Univ Laval, Quebec City, PQ, Canada, Michelle:Johns Hopkins Univ, Baltimore, MD USA, Esther:Hosp Univ 12 Octubre, Madrid, Spain, Guillermo J.:Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain, Jason S.:Univ Michigan, Ann Arbor, MI 48109 USA, Tatsuya:Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan, Rohan:Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan, Stephane:Nancy Univ, Nancy, France, Maria G.:Univ Athens, Athens, Greece
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IOT
Instituto de Ortopedia e Traumatologia - HC/IOT

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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