Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/37205
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorUNLU, Ozan
dc.contributor.authorERKAN, Doruk
dc.contributor.authorBARBHAIYA, Medha
dc.contributor.authorANDRADE, Danieli
dc.contributor.authorNASCIMENTO, Iana
dc.contributor.authorROSA, Renata
dc.contributor.authorBANZATO, Alessandra
dc.contributor.authorPENGO, Vittorio
dc.contributor.authorUGARTE, Amaia
dc.contributor.authorGEROSA, Maria
dc.contributor.authorJI, Lanlan
dc.contributor.authorEFTHYMIOU, Maria
dc.contributor.authorBRANCH, D. Ware
dc.contributor.authorJESUS, Guilherme Ramires de
dc.contributor.authorTINCANI, Angela
dc.contributor.authorBELMONT, H. Michael
dc.contributor.authorFORTIN, Paul R.
dc.contributor.authorPETRI, Michelle
dc.contributor.authorRODRIGUEZ, Esther
dc.contributor.authorPONS-ESTEL, Guillermo J.
dc.contributor.authorKNIGHT, Jason S.
dc.contributor.authorATSUMI, Tatsuya
dc.contributor.authorWILLIS, Rohan
dc.contributor.authorZUILY, Stephane
dc.contributor.authorTEKTONIDOU, Maria G.
dc.date.accessioned2020-08-20T13:27:49Z-
dc.date.available2020-08-20T13:27:49Z-
dc.date.issued2019
dc.identifier.citationARTHRITIS CARE & RESEARCH, v.71, n.1, p.134-141, 2019
dc.identifier.issn2151-464X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37205-
dc.description.abstractObjective Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist regarding the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective of this study was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with SLE with those of aPL-positive patients without SLE. Methods A secure web-based data capture system was used to store patient demographic characteristics and aPL-related clinical and laboratory characteristics. Inclusion criteria included positive aPL according to the updated Sapporo classification criteria. Antiphospholipid antibody-positive patients fulfilling the American College of Rheumatology criteria for the classification of SLE (""aPL with SLE"") and those with no other autoimmune diseases (""aPL only"") were included in the analysis. Results Six hundred seventy-two aPL-positive patients were recruited from 24 international centers; 426 of these patients did not have other autoimmune disease, and 197 had SLE. The frequency of thrombocytopenia, hemolytic anemia, low complement levels, and IgA anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies was higher in the aPL-positive patients with SLE, whereas the frequency of cognitive dysfunction and IgG anti-beta(2)GPI antibodies was higher in the aPL-only group. The frequency of arterial and venous thromboses (including recurrent) as well as pregnancy morbidity was similar in the 2 groups. The prevalence of cardiovascular disease risk factors at the time of entry into the registry entry did not differ between the 2 groups, with the exception of current smoking, which was more frequent in aPL-positive patients with SLE. Conclusion Although the frequencies of thrombosis and pregnancy morbidity are similar in aPL-positive patients with and those without SLE, the diagnosis of SLE in patients with persistently positive aPL is associated with an increased frequency of thrombocytopenia, hemolytic anemia, low complement levels, and positive IgA anti-beta(2)GPI antibodies.eng
dc.description.sponsorshipNew York Community Trust
dc.description.sponsorshipClinical and Translational Science Center at Weill Cornell Medicine [UL1-TR000457]
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofArthritis Care & Research
dc.rightsrestrictedAccesseng
dc.subject.otherclassification criteriaeng
dc.subject.otherconsensus statementeng
dc.subject.otherhydroxychloroquineeng
dc.subject.otherthrombosiseng
dc.subject.othermanifestationseng
dc.subject.otherassociationeng
dc.subject.otherupdateeng
dc.subject.othercohorteng
dc.subject.otherdamageeng
dc.subject.otherriskeng
dc.titleThe Impact of Systemic Lupus Erythematosus on the Clinical Phenotype of Antiphospholipid Antibody-Positive Patients: Results From the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Clinical Database and Repositoryeng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.contributor.groupauthorAntiPhospholipid Syndrome All
dc.identifier.doi10.1002/acr.23584
dc.identifier.pmid29669399
dc.subject.wosRheumatologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalUNLU, Ozan:Weill Cornell Med, New York, NY USA
hcfmusp.author.externalERKAN, Doruk:Weill Cornell Med, New York, NY USA
hcfmusp.author.externalBARBHAIYA, Medha:Weill Cornell Med, New York, NY USA
hcfmusp.author.externalBANZATO, Alessandra:Univ Hosp Padova, Padua, Italy
hcfmusp.author.externalPENGO, Vittorio:Univ Hosp Padova, Padua, Italy
hcfmusp.author.externalUGARTE, Amaia:Hosp Univ Cruces Bizkaia, Baracaldo, Spain
hcfmusp.author.externalGEROSA, Maria:Univ Milan, Milan, Italy
hcfmusp.author.externalJI, Lanlan:Peking Univ, Hosp 1, Beijing, Peoples R China
hcfmusp.author.externalEFTHYMIOU, Maria:UCL, London, England
hcfmusp.author.externalBRANCH, D. Ware:Univ Utah, Salt Lake City, UT USA; Intermt Healthcare, Salt Lake City, UT USA
hcfmusp.author.externalJESUS, Guilherme Ramires de:Univ Estado Rio De Janeiro, Rio De Janeiro, Brazil
hcfmusp.author.externalTINCANI, Angela:Univ Brescia, Brescia, Italy
hcfmusp.author.externalBELMONT, H. Michael:NYU, Sch Med, Langone Med Ctr, New York, NY USA
hcfmusp.author.externalFORTIN, Paul R.:Univ Laval, Quebec City, PQ, Canada
hcfmusp.author.externalPETRI, Michelle:Johns Hopkins Univ, Baltimore, MD USA
hcfmusp.author.externalRODRIGUEZ, Esther:Hosp Univ 12 Octubre, Madrid, Spain
hcfmusp.author.externalPONS-ESTEL, Guillermo J.:Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain
hcfmusp.author.externalKNIGHT, Jason S.:Univ Michigan, Ann Arbor, MI 48109 USA
hcfmusp.author.externalATSUMI, Tatsuya:Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan
hcfmusp.author.externalWILLIS, Rohan:Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan
hcfmusp.author.externalZUILY, Stephane:Nancy Univ, Nancy, France
hcfmusp.author.externalTEKTONIDOU, Maria G.:Univ Athens, Athens, Greece
hcfmusp.description.beginpage134
hcfmusp.description.endpage141
hcfmusp.description.issue1
hcfmusp.description.volume71
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000454412400015
hcfmusp.origem.id2-s2.0-85059245403
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAndreoli L, 2013, CURR RHEUMATOL REP, V15, DOI 10.1007/s11926-013-0343-1eng
hcfmusp.relation.referenceAsherson RA, 2003, LUPUS, V12, P530, DOI 10.1191/0961203303lu394oaeng
hcfmusp.relation.referenceBarbhaiya M, 2016, ARTHRITIS RHEUMATOL, V68eng
hcfmusp.relation.referenceBarbhaiya M, 2016, CURR RHEUMATOL REP, V18, DOI 10.1007/s11926-016-0611-yeng
hcfmusp.relation.referenceCervera R, 2002, ARTHRITIS RHEUM-US, V46, P1019, DOI 10.1002/art.10187eng
hcfmusp.relation.referenceCervera R, 2015, ANN RHEUM DIS, V74, P1011, DOI 10.1136/annrheumdis-2013-204838eng
hcfmusp.relation.referenceEdwards MH, 1997, CIRCULATION, V96, P4380eng
hcfmusp.relation.referenceErkan D, 2018, LUPUS, V27, P399, DOI 10.1177/0961203317724219eng
hcfmusp.relation.referenceErkan D, 2010, LUPUS, V19, P424, DOI 10.1177/0961203309360545eng
hcfmusp.relation.referenceGarcia-Carrasco M, 2007, LUPUS, V16, P366, DOI 10.1177/0961203307077108eng
hcfmusp.relation.referenceHarris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010eng
hcfmusp.relation.referenceHochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928eng
hcfmusp.relation.referenceJung HJ, 2010, ARTHRITIS RHEUM-US, V62, P863, DOI 10.1002/art.27289eng
hcfmusp.relation.referenceKaiser R, 2009, ANN RHEUM DIS, V68, P238, DOI 10.1136/ard.2008.093013eng
hcfmusp.relation.referenceKelchtermans H, 2016, J THROMB HAEMOST, V14, P1530, DOI 10.1111/jth.13379eng
hcfmusp.relation.referenceKim SK, 2017, LUPUS, V26, P1540, DOI 10.1177/0961203317709346eng
hcfmusp.relation.referenceKozora E, 2014, CLIN EXP RHEUMATOL, V32, P34eng
hcfmusp.relation.referenceMehrani T, 2011, J RHEUMATOL, V38, P64, DOI 10.3899/jrheum.100568eng
hcfmusp.relation.referenceMiyakis S, 2006, J THROMB HAEMOST, V4, P295, DOI 10.1111/j.1538-7836.2006.01753.xeng
hcfmusp.relation.referenceNuri E, 2017, IMMUNOL RES, V65, P17, DOI 10.1007/s12026-016-8812-zeng
hcfmusp.relation.referencePengo V, 2009, J THROMB HAEMOST, V7, P1737, DOI 10.1111/j.1538-7836.2009.03555.xeng
hcfmusp.relation.referencePetri M, 1996, LUPUS, V5, pS16, DOI 10.1177/096120339600500105eng
hcfmusp.relation.referencePetri M, 2012, ARTHRITIS RHEUM-US, V64, P2677, DOI 10.1002/art.34473eng
hcfmusp.relation.referencePons-Estel GJ, 2017, J AUTOIMMUN, V76, P10, DOI 10.1016/j.jaut.2016.10.004eng
hcfmusp.relation.referencePosch F, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0807-7eng
hcfmusp.relation.referenceRand JH, 2010, BLOOD, V115, P2292, DOI 10.1182/blood-2009-04-213520eng
hcfmusp.relation.referenceRuiz-Irastorza G, 2006, LUPUS, V15, P577, DOI 10.1177/0961203306071872eng
hcfmusp.relation.referenceSchmidt-Tanguy A, 2013, J THROMB HAEMOST, V11, P1927, DOI 10.1111/jth.12363eng
hcfmusp.relation.referenceTaraborelli M, 2016, LUPUS, V25, P1365, DOI 10.1177/0961203316637431eng
hcfmusp.relation.referenceTektonidou MG, 2006, ARCH INTERN MED, V166, P2278, DOI 10.1001/archinte.166.20.2278eng
hcfmusp.relation.referenceTektonidou MG, 2016, ARTHRITIS RHEUMATOL, V68, P2680, DOI 10.1002/art.39758eng
hcfmusp.relation.referenceTektonidou MG, 2009, ARTHRIT RHEUM-ARTHR, V61, P29, DOI 10.1002/art.24232eng
hcfmusp.relation.referenceUnlu O, 2016, EUR J RHEUMATOL, V3, P75, DOI 10.5152/eurjrheum.2015.0085eng
dc.description.indexMEDLINEeng
dc.identifier.eissn2151-4658
hcfmusp.citation.scopus19-
hcfmusp.scopus.lastupdate2022-04-29-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IOT
Instituto de Ortopedia e Traumatologia - HC/IOT

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_UNLU_The_Impact_of_Systemic_Lupus_Erythematosus_on_the_2019.PDF.pdf
  Restricted Access
publishedVersion (English)310.14 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.