LIM/32 - Laboratório de Otorrinolaringologia

O Laboratório de Otorrinolaringologia é ligado ao Departamento de Oftalmologia e otorrinolaringologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: pesquisa experimental e análise crítica das técnicas cirúrgicas sobre osso temporal; pesquisa em próteses eletrônicas cirurgicamente implantáveis para deficiência auditiva profunda; bases clínicas e experimentais da fisiopatologia e tratamento do zumbido e da hiperacusia; mecanismos fisiopatológicos dos distúrbios vestibulares periféricos; pesquisa anatômica e experimental das propriedades biomecânicas da laringe no desempenho das funções respiratória, fonatória e esfinctérica; distúrbios do anel linfático de Waldeyer e sua influência no desenvolvimento craniofacial e no sistema estomagotognático; correlação de fatores estruturais e microbiológicos na fisiopatogenia das rinossinusites; estudo da patogênese de nasoangiofibroma juvenil; alterações funcionais na mucosa nasal exposta a poluentes ambientais alérgenos.

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Recent Submissions

  1. The influence of stimulation levels on auditory thresholds and speech recognition in adult cochlear implant users

    COCHLEAR IMPLANTS INTERNATIONAL, v.22, n.1, p.42-48, 2021

    Objective: This study aims to evaluate the influence of minimum and maximum stimulation levels on auditory thresholds and speech recognition abilities in adult cochlear implant users. Method: Fifteen adults implanted with a Cochlear (R) device with over 12 months listening experience. Participant...

  2. Long-Term Outcome With an Active Middle Ear Implant in Patients to Bilateral Aural Atresia

    OTOLOGY & NEUROTOLOGY, v.42, n.10, p.1527-1533, 2021

    Objective: To describe the audiological results and complications following active middle ear implant (AMEI) surgery in users with bilateral ear atresia. Study Design: Observational and retrospective longitudinal follow-up. Setting: A tertiary referral hospital for hearing rehabilitation and cran...

  3. Emergências otorrinolaringológicas

    Sennes, Luiz Ubirajara. Emergências otorrinolaringológicas. In: Velasco, Irineu Tadeu; Brandão Neto, Rodrigo Antonio; Souza, Heraldo Possolo de; Marino, Lucas Oliveira; Marchini, Júlio Flávio Meirelles; Alencar, Júlio César Garcia de (eds). Medicina de emergência: abordagem prática [15.ed.]. BARUERI: Manole, 2021. p.1602-1615.

  4. Intranasal Leptin Reduces Mortality from Opioid Overdose in Mice


  5. Master Regulators of Epithelial-Mesenchymal Transition and WNT Signaling Pathways in Juvenile Nasopharyngeal Angiofibromas

    BIOMEDICINES, v.9, n.9, article ID 1258, 14p, 2021

    Juvenile nasopharyngeal angiofibroma (JNA) is a rare fibrovascular benign tumor showing an invasive growth pattern and affecting mainly male adolescents. We investigated the role of epithelial-mesenchymal transition (EMT) and WNT signaling pathways in JNA. Gene expression profiles using nine JNA ...

  6. Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil

    BMJ OPEN, v.11, n.6, article ID e051706, 9p, 2021

    Introduction COVID-19 may lead to persistent and potentially incapacitating clinical manifestations (post-acute sequelae of SARS-CoV-2 infection (PASC)). Using easy-to-apply questionnaires and scales (often by telephone interviewing), several studies evaluated samples of COVID-19 inpatients from ...

  7. Management of acquired cholesteatoma in patients with craniofacial anomalies: An institutional experience

    AMERICAN JOURNAL OF OTOLARYNGOLOGY, v.41, n.6, article ID 102591, 5p, 2020

    Purpose: To analyze the surgical management of cholesteatoma in patients with craniofacial abnormalities, cleft lip/palate by reviewing the institutional experience. The secondary aim was to identify and describe the epidemiological profile of the collected data, and to relate the cleft palate an...

  8. BMP-7, MMP-9, and TGF-beta tissue remodeling proteins and their correlations with interleukins 6 and 10 in chronic rhinosinusitis

    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, v.278, n.11, p.4335-4343, 2021

    Introduction Chronic rhinosinusitis without nasal polyposis (CRSsNP) and Chronic rhinosinusitis with nasal polyposis (CRSwNP) present distinct tissue remodeling processes. The proteins involved in the process of tissue remodeling have their production and activity related to the inflammatory envi...

  9. Bipedicled Vocal Fold Mucosal Flap Use in Phonomicrosurgery: Case Series

    JOURNAL OF VOICE, v.35, n.5, p.793-799, 2021

    Objectives. The objective of this study was to present a novel surgical technique involving the use of a ""bipedicled vocal fold mucosal flap"" to repair a mucosal defect and to evaluate the outcomes of patients in whom it was used. Material and methods. This was a retrospective study of 6 clinic...

  10. Sensitivity and Specificity of Bedside Screening Tests for Detection of Aspiration in Patients Admitted to a Public Rehabilitation Hospital

    DYSPHAGIA, v.36, n.5, p.821-830, 2021

    Early detection of dysphagia and specifically aspiration is essential to prevent and reduce complications of hospitalized patients in rehabilitation centers. Bedside screening test are often used to evaluate swallowing disorders, but their results may be questionable due to insufficient and incon...