LIM/36 - Laboratório de Pediatria Clínica
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Prevalência e desfechos da sepse em crianças internadas em hospitais públicos e privados na América Latina: um estudo observacional multicêntrico
REVISTA BRASILEIRA DE TERAPIA INTENSIVA, v.33, n.2, p.231-242, 2021
ABSTRACT Objective: To report the prevalence and outcomes of sepsis in children admitted to public and private hospitals. Methods: Post hoc analysis of the Latin American Pediatric Sepsis Study (LAPSES) data, a cohort study that analyzed the prevalence and outcomes of sepsis in critically ill chi...
Allergic sensitization pattern of patients in Brazil
JORNAL DE PEDIATRIA, v.97, n.4, p.387-395, 2021
Objective: Allergic sensitization is one of the key components for the development of allergies. Polysensitization seems to be related to the persistence and severity of allergic diseases. Furthermore, allergic sensitization has a predictive role in the development of allergies. The aim of this s...
Dupilumab Provides Significant Clinical Benefit in a Phase 3 Trial in Adolescents with Uncontrolled Atopic Dermatitis Irrespective of Prior Systemic Immunosuppressant Use
ACTA DERMATO-VENEREOLOGICA, v.101, article ID adv00504, 3p, 2021
Prevalence and outcomes of thrombotic and hemorrhagic complications in pediatric acute promyelocytic leukemia in a tertiary Brazilian center
HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, n.3, p.309-312, 2021
Introduction: Little attention is given to thrombosis associated with pediatric acute promyelocytic leukemia (APL). This study describes the thrombotic and hemorrhagic manifestations of APL in pediatric patients and evaluates their hemostasis, based on coagulation tests. Methods: Inclusion criter...
CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking
JCI INSIGHT, v.6, n.16, article ID e148652, 20p, 2021
Neutrophils are produced in the BM in a process called granulopoiesis, in which progenitor cells sequentially develop into mature neutrophils. During the developmental process, which is finely regulated by distinct transcription factors, neutrophils acquire the ability to exit the BM, properly di...
Chromoanagenesis Event Underlies a de novo Pericentric and Multiple Paracentric Inversions in a Single Chromosome Causing Coffin-Siris Syndrome
FRONTIERS IN GENETICS, v.12, article ID 708348, 11p, 2021
Chromoanagenesis is a descriptive term that encompasses classes of catastrophic mutagenic processes that generate localized and complex chromosome rearrangements in both somatic and germline genomes. Herein, we describe a 5-year-old female presenting with a constellation of clinical features cons...
Biased pathogenic assertions of loss of function variants challenge molecular diagnosis of admixed individuals
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, v.187, n.3, Special Issue, p.357-363, 2021
Diagnosis of individuals affected by monogenic disorders was significantly improved by next-generation sequencing targeting clinically relevant genes. Whole exomes yield a large number of variants that require several filtering steps, prioritization, and pathogenicity classification. Among the cr...
Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents
ALLERGOLOGIA ET IMMUNOPATHOLOGIA, v.48, n.3, p.259-264, 2020
The clinical history is of importance in the investigation of allergic diseases but does have limitations. Many allergic conditions will be over-diagnosed if anamnesis alone is used for diagnostic criteria. Serum total immunoglobulin E (TIgE) quantification, as well as panels containing allergens...
Allogeneic Hematopoietic Stem Cell Transplantation for Children and Adolescents with Acute Myeloid Leukemia in Brazil: A Multicentric Retrospective Study
CELL TRANSPLANTATION, v.29, article ID 963689720949175, 10p, 2020
The survival rates of children with high-risk acute myeloid leukemia (AML) treated with hematopoietic stem cell transplant (HSCT) range from 60% to 70% in high-income countries. The corresponding rate for Brazilian children with AML who undergo HSCT is unknown. We conducted a retrospective analys...
Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study
JOURNAL OF CLINICAL IMMUNOLOGY, v.41, n.7, p.1479-1489, 2021
Purpose There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of Immunity (IEI) and many unresolved questions. We aimed to describe the clinical outcome of SARS-CoV-2 infection in Brazilian IEI patients and identify factors influencing the infection. Methods We did a c...