LIM/36 - Laboratório de Pediatria Clínica

O Laboratório de Pediatria Clínica é ligado ao Departamento de Pediatria da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: marcadores celulares e moleculares de infecções pediátricas; investigação molecular de doenças genéticas; investigação laboratorial de imunodeficiência; alergia alimentar na infância; investigação laboratorial de doenças endocrinológicas pediátricas; fisiopatologia e diagnóstico de afecções nefrológicas em crianças; fisiopatologia e diagnóstico de doenças autoimunes; investigação laboratorial de neoplasias pediátricas; investigação clínica e laboratorial do binômio mãe-filho e genômica pediátrica.

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Recent Submissions

  1. Prevalência e desfechos da sepse em crianças internadas em hospitais públicos e privados na América Latina: um estudo observacional multicêntrico

    REVISTA BRASILEIRA DE TERAPIA INTENSIVA, v.33, n.2, p.231-242, 2021

    ABSTRACT Objective: To report the prevalence and outcomes of sepsis in children admitted to public and private hospitals. Methods: Post hoc analysis of the Latin American Pediatric Sepsis Study (LAPSES) data, a cohort study that analyzed the prevalence and outcomes of sepsis in critically ill chi...

  2. Allergic sensitization pattern of patients in Brazil

    JORNAL DE PEDIATRIA, v.97, n.4, p.387-395, 2021

    Objective: Allergic sensitization is one of the key components for the development of allergies. Polysensitization seems to be related to the persistence and severity of allergic diseases. Furthermore, allergic sensitization has a predictive role in the development of allergies. The aim of this s...

  3. Dupilumab Provides Significant Clinical Benefit in a Phase 3 Trial in Adolescents with Uncontrolled Atopic Dermatitis Irrespective of Prior Systemic Immunosuppressant Use

    ACTA DERMATO-VENEREOLOGICA, v.101, article ID adv00504, 3p, 2021

  4. Prevalence and outcomes of thrombotic and hemorrhagic complications in pediatric acute promyelocytic leukemia in a tertiary Brazilian center

    HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, n.3, p.309-312, 2021

    Introduction: Little attention is given to thrombosis associated with pediatric acute promyelocytic leukemia (APL). This study describes the thrombotic and hemorrhagic manifestations of APL in pediatric patients and evaluates their hemostasis, based on coagulation tests. Methods: Inclusion criter...

  5. CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking

    JCI INSIGHT, v.6, n.16, article ID e148652, 20p, 2021

    Neutrophils are produced in the BM in a process called granulopoiesis, in which progenitor cells sequentially develop into mature neutrophils. During the developmental process, which is finely regulated by distinct transcription factors, neutrophils acquire the ability to exit the BM, properly di...

  6. Chromoanagenesis Event Underlies a de novo Pericentric and Multiple Paracentric Inversions in a Single Chromosome Causing Coffin-Siris Syndrome

    FRONTIERS IN GENETICS, v.12, article ID 708348, 11p, 2021

    Chromoanagenesis is a descriptive term that encompasses classes of catastrophic mutagenic processes that generate localized and complex chromosome rearrangements in both somatic and germline genomes. Herein, we describe a 5-year-old female presenting with a constellation of clinical features cons...

  7. Biased pathogenic assertions of loss of function variants challenge molecular diagnosis of admixed individuals


    Diagnosis of individuals affected by monogenic disorders was significantly improved by next-generation sequencing targeting clinically relevant genes. Whole exomes yield a large number of variants that require several filtering steps, prioritization, and pathogenicity classification. Among the cr...

  8. Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents

    ALLERGOLOGIA ET IMMUNOPATHOLOGIA, v.48, n.3, p.259-264, 2020

    The clinical history is of importance in the investigation of allergic diseases but does have limitations. Many allergic conditions will be over-diagnosed if anamnesis alone is used for diagnostic criteria. Serum total immunoglobulin E (TIgE) quantification, as well as panels containing allergens...

  9. Allogeneic Hematopoietic Stem Cell Transplantation for Children and Adolescents with Acute Myeloid Leukemia in Brazil: A Multicentric Retrospective Study

    CELL TRANSPLANTATION, v.29, article ID 963689720949175, 10p, 2020

    The survival rates of children with high-risk acute myeloid leukemia (AML) treated with hematopoietic stem cell transplant (HSCT) range from 60% to 70% in high-income countries. The corresponding rate for Brazilian children with AML who undergo HSCT is unknown. We conducted a retrospective analys...

  10. Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study

    JOURNAL OF CLINICAL IMMUNOLOGY, v.41, n.7, p.1479-1489, 2021

    Purpose There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of Immunity (IEI) and many unresolved questions. We aimed to describe the clinical outcome of SARS-CoV-2 infection in Brazilian IEI patients and identify factors influencing the infection. Methods We did a c...