Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMONTENEGRO, Fabio Luiz de Menezes-
dc.contributor.authorLOURENCO JUNIOR, Delmar Muniz-
dc.contributor.authorTAVARES, Marcos Roberto-
dc.contributor.authorARAP, Sergio Samir-
dc.contributor.authorNASCIMENTO JUNIOR, Climerio Pereira-
dc.contributor.authorMASSONI NETO, Ledo Mazzei-
dc.contributor.authorD'ALESSANDRO, Andre-
dc.contributor.authorTOLEDO, Rodrigo Almeida-
dc.contributor.authorCOUTINHO, Flavia Lima-
dc.contributor.authorBRANDAO, Lenine Garcia-
dc.contributor.authorSILVA FILHO, Gilberto de Britto e-
dc.contributor.authorCORDEIRO, Anoi Castro-
dc.contributor.authorTOLEDO, Sergio Pereira Almeida-
dc.identifier.citationCLINICS, v.67, suppl.1, p.131-139, 2012-
dc.description.abstractMost cases of sporadic primary hyperparathyroidism present disturbances in a single parathyroid gland and the surgery of choice is adenomectomy. Conversely, hyperparathyroidism associated with multiple endocrine neoplasia type 1 (hyperparathyroidism/multiple endocrine neoplasia type 1) is an asynchronic, asymmetrical multiglandular disease and it is surgically approached by either subtotal parathyroidectomy or total parathyroidectomy followed by parathyroid auto-implant to the forearm. In skilful hands, the efficacy of both approaches is similar and both should be complemented by prophylactic thymectomy. In a single academic center, 83 cases of hyperparathyroidism/multiple endocrine neoplasia type 1 were operated on from 1987 to 2010 and our first surgical choice was total parathyroidectomy followed by parathyroid auto-implant to the non-dominant forearm and, since 1997, associated transcervical thymectomy to prevent thymic carcinoid. Overall, 40% of patients were given calcium replacement (mean intake 1.6 g/day) during the first months after surgery, and this fell to 28% in patients with longer follow-up. These findings indicate that several months may be needed in order to achieve a proper secretion by the parathyroid auto-implant. Hyperparathyroidism recurrence was observed in up to 15% of cases several years after the initial surgery. Thus, long-term follow-up is recommended for such cases. We conclude that, despite a tendency to subtotal parathyroidectomy worldwide, total parathyroidectomy followed by parathyroid auto-implant is a valid surgical option to treat hyperparathyroidism/multiple endocrine neoplasia type 1. Larger comparative systematic studies are needed to define the best surgical approach to hyperparathyroidism/multiple endocrine neoplasia type 1.-
dc.description.sponsorshipFAPESP [2009/15386-6, 11942/2009]-
dc.description.sponsorshipCNPq [401990/2010-9]-
dc.subjectParathyroid glands-
dc.subjectParathyroid neoplasms-
dc.subject.otherasymptomatic primary hyperparathyroidism-
dc.subject.other1-associated primary hyperparathyroidism-
dc.subject.other3rd international workshop-
dc.subject.othersubtotal parathyroidectomy-
dc.subject.othertranscervical thymectomy-
dc.subject.otherthymic carcinoids-
dc.subject.othersurgical approach-
dc.subject.otheri syndrome-
dc.titleTotal parathyroidectomy in a large cohort of cases with hyperparathyroidism associated with multiple endocrine neoplasia type 1: experience from a single academic center-
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO-
dc.subject.wosMedicine, General & Internal-
hcfmusp.description.issuesuppl 1-
hcfmusp.publisher.citySAO PAULO-
hcfmusp.relation.referenceArnalsteen LC, 2002, SURGERY, V132, P1119, DOI 10.1067/msy.2002.128607-
hcfmusp.relation.referenceBarreira CESR, 2011, WORLD J SURG, V35, P2440, DOI 10.1007/s00268-011-1261-x-
hcfmusp.relation.referenceBilezikian JP, 2002, J CLIN ENDOCR METAB, V87, P5353, DOI 10.1210/jc.2002-021370-
hcfmusp.relation.referenceBilezikian JP, 2009, J CLIN ENDOCR METAB, V94, P335, DOI 10.1210/jc.2008-1763-
hcfmusp.relation.referenceBoguszewski CL, 2010, ARQ BRAS ENDOCRINOL, V54, P705, DOI 10.1590/S0004-27302010000800007-
hcfmusp.relation.referenceBrandi ML, 2001, J CLIN ENDOCR METAB, V86, P5658, DOI 10.1210/jc.86.12.5658-
hcfmusp.relation.referenceBurgess JR, 2001, CLIN ENDOCRINOL, V55, P689, DOI 10.1046/j.1365-2265.2001.01348.x-
hcfmusp.relation.referenceBurgess JR, 1998, ARCH SURG-CHICAGO, V133, P126, DOI 10.1001/archsurg.133.2.126-
hcfmusp.relation.referenceCaliseo Caio Tosato, 2011, Rev Col Bras Cir, V38, P85-
hcfmusp.relation.referenceCordeiro AC, 1998, AM J SURG, V175, P52, DOI 10.1016/S0002-9610(97)00228-6-
hcfmusp.relation.referenceCoutinho FL, 2010, CLIN ENDOCRINOL, V72, P462, DOI 10.1111/j.1365-2265.2009.03672.x-
hcfmusp.relation.referenceCoutinho FL, 2012, CLINICS, V67, P169, DOI 10.6061/clinics/2012(Sup01)28-
hcfmusp.relation.referenceDamiani D, 1998, J PEDIATR ENDOCR MET, V11, P83-
hcfmusp.relation.referenceEastell R, 2009, J CLIN ENDOCR METAB, V94, P340, DOI 10.1210/jc.2008-1758-
hcfmusp.relation.referenceElaraj DM, 2003, SURGERY, V134, P858, DOI 10.1016/S0039-6060(03)00406-9-
hcfmusp.relation.referenceEller-Vainicher C, 2009, J BONE MINER RES, V24, P1404, DOI [10.1359/jbmr.090304, 10.1359/JBMR.090304]-
hcfmusp.relation.referenceFalchetti A, 2009, GENET MED, V11, P825, DOI 10.1097/GIM.0b013e3181be5c97-
hcfmusp.relation.referenceFalchetti A, 2008, NAT CLIN PRACT ENDOC, V4, P351, DOI 10.1038/ncpendmet0816-
hcfmusp.relation.referenceFalchetti A, 2009, J CLIN ENDOCR METAB, V94, P1518, DOI 10.1210/jc.2009-0494-
hcfmusp.relation.referenceGibril F, 2003, J CLIN ENDOCR METAB, V88, P1066, DOI 10.1210/jc.2002-021314-
hcfmusp.relation.referenceGoudet P, 2009, WORLD J SURG, V33, P1197, DOI 10.1007/s00268-009-9980-y-
hcfmusp.relation.referenceGoudet P, 2010, WORLD J SURG, V34, P249, DOI 10.1007/s00268-009-0290-1-
hcfmusp.relation.referenceGoudet P, 2001, WORLD J SURG, V25, P886-
hcfmusp.relation.referenceHEATH H III, 1991, Journal of Bone and Mineral Research, V6, pS63-
hcfmusp.relation.referenceHELLMAN P, 1992, WORLD J SURG, V16, P718-
hcfmusp.relation.referenceHellman P, 1998, SURGERY, V124, P993, DOI 10.1016/S0039-6060(98)70040-6-
hcfmusp.relation.referenceHubbard JGH, 2002, LANGENBECK ARCH SURG, V386, P553, DOI 10.1007/s00423-002-0275-0-
hcfmusp.relation.referenceHubbard JGH, 2006, ARCH SURG-CHICAGO, V141, P235, DOI 10.1001/archsurg.141.3.235-
hcfmusp.relation.referenceKovatcheva RD, 2010, AM J ROENTGENOL, V195, P830, DOI 10.2214/AJR.09.3932-
hcfmusp.relation.referenceLambert LA, 2005, ARCH SURG-CHICAGO, V140, P374, DOI 10.1001/archsurg.140.4.374-
hcfmusp.relation.referenceLim LC, 2006, J INTERN MED, V259, P428, DOI 10.1111/j.1365-2796.2006.01619.x-
hcfmusp.relation.referenceLips CJM, 2009, EXP REV ENDOCRINOL M, V4, P371, DOI 10.1586/eem.09.22-
hcfmusp.relation.referenceLourenco DM, 2010, J BONE MINER RES, V25, P2382, DOI 10.1002/jbmr.125-
hcfmusp.relation.referenceLourenco DM, 2008, EUR J ENDOCRINOL, V159, P259, DOI 10.1530/EJE-08-0153-
hcfmusp.relation.referenceLourenco DM, 2012, CLINICS, V67, P99, DOI 10.6061/clinics/2012(Sup01)17-
hcfmusp.relation.referenceLourenco Delmar Muniz Jr, 2007, Clinics (Sao Paulo), V62, P465-
hcfmusp.relation.referenceMALMAEUS J, 1986, WORLD J SURG, V10, P668-
hcfmusp.relation.referenceMarx SJ, 2005, NAT REV CANCER, V5, P367, DOI 10.1038/nrc1610-
hcfmusp.relation.referenceMontenegro F, 2010, REV BRAS CIR CABECA, V39, P99-
hcfmusp.relation.referenceMontenegro Fabio Luiz de Menezes, 2006, Sao Paulo Med J, V124, P42-
hcfmusp.relation.referenceMontenegro FLD, 2007, HEAD NECK-J SCI SPEC, V29, P296, DOI 10.1002/hed.20506-
hcfmusp.relation.referenceMontenegro FLD, 2007, NEPHROL DIAL TRANSPL, V22, P293, DOI 10.1093/ndt/gfl503-
hcfmusp.relation.referenceMontenegro FLM, 2009, REV BRAS CIR CAB PES, V38, P4-
hcfmusp.relation.referenceMontenegro FLM, 2005, REV COL BRAS CIR, V32, P115, DOI 10.1590/S0100-69912005000300003-
hcfmusp.relation.referenceMontenegro FLM, 2010, REV BRAS CIR CAB PES, V39, P174-
hcfmusp.relation.referenceMontenegro FLM, 2008, REV BRAS CIR CABECA, V37, P71-
hcfmusp.relation.referenceMontenegro FM, 2011, ARQ BRAS ENDOCRINOL, V55, P249-
hcfmusp.relation.referenceMoyes VJ, 2010, INT J ENDOCRINOL, DOI 10.1155/2010/906163-
hcfmusp.relation.referencePeacock M, 2005, J CLIN ENDOCR METAB, V90, P135, DOI 10.1210/jc.2004-0842-
hcfmusp.relation.referencePiecha G, 2010, INT J ENDOCRINOL, DOI 10.1155/2010/928383-
hcfmusp.relation.referencePowell AC, 2008, SURGERY, V144, P878, DOI 10.1016/j.surg.2008.08.031-
hcfmusp.relation.referenceRubin MR, 2008, J CLIN ENDOCR METAB, V93, P3462, DOI 10.1210/jc.2007-1215-
hcfmusp.relation.referenceSalmeron MDB, 2010, WORLD J SURG, V34, P1325, DOI 10.1007/s00268-010-0605-2-
hcfmusp.relation.referenceSchneider R, 2011, WORLD J SURG, V35, P1260, DOI 10.1007/s00268-011-1079-6-
hcfmusp.relation.referenceSchreinemakers JMJ, 2011, WORLD J SURG, V35, P1993, DOI 10.1007/s00268-011-1068-9-
hcfmusp.relation.referenceSHEPHERD JJ, 1991, ARCH SURG-CHICAGO, V126, P935-
hcfmusp.relation.referenceShih RYW, 2009, ENDOCR PRACT, V15, P567, DOI 10.4158/EP09045.CRR1-
hcfmusp.relation.referenceSilverberg SJ, 2006, NAT CLIN PRACT ENDOC, V2, P494, DOI 10.1038/ncpendmet0265-
hcfmusp.relation.referenceStalberg P, 2009, WORLD J SURG, V33, P2234, DOI 10.1007/s00268-009-9924-6-
hcfmusp.relation.referenceTeh BT, 1997, MEDICINE, V76, P21, DOI 10.1097/00005792-199701000-00002-
hcfmusp.relation.referenceToledo RA, 2012, CLINICS, V67, P3, DOI 10.6061/clinics/2012(Sup01)02-
hcfmusp.relation.referenceToledo RA, 2007, CLIN ENDOCRINOL, V67, P377, DOI 10.1111/j.1365-2265.2007.02895.x-
hcfmusp.relation.referenceTonelli F, 2012, CLINICS, V67, P155, DOI 10.6061/clinics/2012(Sup01)26-
hcfmusp.relation.referenceTonelli F, 2007, ANN SURG, V246, P1075, DOI 10.1097/SLA.0b013e31811f4467-
hcfmusp.relation.referenceTonelli F, 2009, ENDOCR J, V56, P827-
hcfmusp.relation.referenceTonelli F, 2000, WORLD J SURG, V24, P556-
hcfmusp.relation.referenceVeldman MW, 2008, AM J ROENTGENOL, V191, P1740, DOI 10.2214/AJR.07.3431-
hcfmusp.relation.referenceWaldmann J, 2010, BRIT J SURG, V97, P1528, DOI 10.1002/bjs.7154-
hcfmusp.relation.referenceWELLS SA, 1975, SURGERY, V78, P34-
hcfmusp.relation.referenceWELLS SA, 1980, ANN SURG, V192, P451, DOI 10.1097/00000658-198010000-00003-
hcfmusp.relation.referenceWELLS SA, 1976, NEW ENGL J MED, V295, P57, DOI 10.1056/NEJM197607082950201-
hcfmusp.relation.referenceWesterdahl J, 2006, ARCH SURG-CHICAGO, V141, P589, DOI 10.1001/archsurg.141.6.589-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/25
LIM/25 - Laboratório de Endocrinologia Celular e Molecular

Artigos e Materiais de Revistas Científicas - LIM/28
LIM/28 - Laboratório de Cirurgia Vascular e da Cabeça e Pescoço

Files in This Item:
File Description SizeFormat 
art_MONTENEGRO_Total_parathyroidectomy_in_a_large_cohort_of_cases_2012.PDFpublishedVersion (English)617.8 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.