LIM/46 - Laboratório de Parasitologia Médica
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Disparity between scientific accomplishment and biotechnology availability in Brazil
SCIENCE PROGRESS, v.104, n.2, article ID 368504211028373, 3p, 2021
Despite being among the world's leaders in scientific output, Brazil ranks 66th among countries in the production of reagents and supplies needed for state-of-the-art scientific analyses. The production of needed reagents and equipment for experimental analyses and patient diagnostics is sorely l...
Chikungunya virus ECSA lineage reintroduction in the northeasternmost region of Brazil
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.105, 2021
The Northeast region of Brazil registered the second-highest incidence proportion of Chikungunya fever in 2019. In that year, an outbreak consisting of patients presenting with febrile disease associated with joint pain was reported by the public primary health care service in the city of Natal, ...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence and Risk Factors Among Oligo/Asymptomatic Healthcare Workers: Estimating the Impact of Community Transmission
CLINICAL INFECTIOUS DISEASES, v.73, n.5, p.E1214-E1218, 2021
We evaluated the seroprevalence of SARS-CoV-2 and risk factors among 4987 oligo/asymptomatic healthcare workers; seroprevalence was 14% and factors associated with SARS-CoV-2 infection were lower educational level (aOR, 1.93; 95% CI, 1.03-3.60), using public transport to work (aOR, 1.65; 95% CI, ...
Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
PLOS ONE, v.16, n.8, article ID e0256357, 9p, 2021
Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopha...
Deep neural network-estimated electrocardiographic age as a mortality predictor
NATURE COMMUNICATIONS, v.12, n.1, article ID 5117, 10p, 2021
The electrocardiogram (ECG) is the most commonly used exam for the screening and evaluation of cardiovascular diseases. Here, the authors propose that the age predicted by artificial intelligence from the raw ECG tracing can be a measure of cardiovascular health and provide prognostic information...
A Novel Saliva RT-LAMP Workflow for Rapid Identification of COVID-19 Cases and Restraining Viral Spread
DIAGNOSTICS, v.11, n.8, article ID 1400, 19p, 2021
Rapid diagnostics is pivotal to curb SARS-CoV-2 transmission, and saliva has emerged as a practical alternative to naso/oropharyngeal (NOP) specimens. We aimed to develop a direct RT-LAMP (reverse transcription loop-mediated isothermal amplification) workflow for viral detection in saliva, and to...
SARS-CoV-2 in a stream running through an underprivileged, underserved, urban settlement in Sa tilde o Paulo, Brazil: A 7-month follow-up
ENVIRONMENTAL POLLUTION, v.290, article ID 118003, 7p, 2021
COVID-19 pandemic has led to concerns on the circulation of SARS-CoV-2 in the environment, its infectivity from the environment and, the relevance of transmission via environmental compartments. During 31 weeks, water samples were collected from a heavily contaminated stream going through an urba...
Germline and Somatic mutations in postmenopausal breast cancer patients
CLINICS, v.76, article ID e2837, 23p, 2021
OBJECTIVES: In breast cancer (BC) patients, the frequency of germline BRCA mutations (gBRCA) may vary according to the ethnic background, age, and family history of cancer. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is the second most common somatic mutated ge...
A Genome-Wide Association Study Identifies Novel Susceptibility loci in Chronic Chagas Cardiomyopathy
CLINICAL INFECTIOUS DISEASES, v.73, n.4, p.672-679, 2021
Background. Chagas disease is an infectious disease caused by the parasite Trypanosoma cruzi and is endemic from Latin American countries. The goal of our study was to identify novel genetic loci associated with chronic Chagas cardiomyopathy development in Chagas disease patients from different L...
Epidemiology and evolution of Zika virus in Minas Gerais, Southeast Brazil
INFECTION GENETICS AND EVOLUTION, v.91, article ID 104785, 7p, 2021
Autochthonous Zika virus (ZIKV) transmission in Brazil was first identified in April 2015 in Brazil, with the first ZIKV-associated microcephaly cases detected in October 2015. Despite efforts on understanding ZIKV transmission in Brazil, little is known about the virus epidemiology and genetic d...