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Title: Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
Authors: GOUVEIA, Flavia VenetucciGERMANN, JuergenDEVENYI, Gabriel A.MORAIS, Rosa M. C. B.SANTOS, Ana Paula M.FONOFF, Erich T.HAMANI, ClementBRENTANI, HelenaCHAKRAVARTY, M. MallarMARTINEZ, Raquel C. R.
Citation: BJPSYCH OPEN, v.6, n.5, article ID e85, 4p, 2020
Abstract: Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions.
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Artigos e Materiais de Revistas Científicas - FM/MNE
Departamento de Neurologia - FM/MNE

Artigos e Materiais de Revistas Científicas - FM/MPS
Departamento de Psiquiatria - FM/MPS

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/23
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

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