LIM/48 - Laboratório de Imunologia

O Laboratório de Imunologia é ligado ao Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: interação hospedeiro-parasita em doenças tropicais: doença de Chagas, malária, paracoccidioidomicose, imunidade inata e soroepidemiologia de doenças tropicais, imunopatogenia da leishmaniose, análise molecular da resistência a drogas em leishmaniose, infecções em imunodeprimidos; infecções endêmicas, virais, micoses invasivas, tuberculose e protozooses emergentes, imunidade em infecção por HIV.

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Recent Submissions

  1. Coxsackievirus A6 strains causing an outbreak of hand-foot-and-mouth disease in Northeastern Brazil in 2018


    Hand-foot-and-mouth disease (HFMD) is a highly contagious viral disease commonly associated to Enteroviruses (EV). During 2018, Brazil faced massive HFMD outbreaks spread across the country. This study aimed to characterize the EV responsible for the HFMD outbreak that occurred in Paraiba State, ...

  2. The Dermatophyte Trichophyton rubrum Induces Neutrophil Extracellular Traps Release by Human Neutrophils

    JOURNAL OF FUNGI, v.8, n.2, article ID 147, 9p, 2022

    Neutrophils are the first leukocytes recruited to the site of infection and are thought to be responsible for fungal elimination from the skin such as dermatophytes. Neutrophils are able to secrete reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) that can kill different fun...

  3. Immunogenicity and safety of primary fractional-dose yellow fever vaccine in autoimmune rheumatic diseases

    PLOS NEGLECTED TROPICAL DISEASES, v.15, n.11, article ID e0010002, 17p, 2021

    Background Brazil faced a yellow fever(YF) outbreak in 2016-2018 and vaccination was considered for autoimmune rheumatic disease patients(ARD) with low immunosuppression due to YF high mortality. Objective This study aimed to evaluate, prospectively for the first time, the short-term immunogenici...

  4. Influenza A(H3N2)/Singapore Component Vaccine in Systemic Lupus Erythematosus: A Distinct Pattern of Immunogenicity

    ARTHRITIS & RHEUMATOLOGY, v.73, suppl.9, Special Issue, p.3668-3668, 2021

  5. Immunogenicity and Safety of an Inactivated Virus Vaccine Against SARS-CoV-2 in Patients with Autoimmune Rheumatic Diseases

    ARTHRITIS & RHEUMATOLOGY, v.73, suppl.9, Special Issue, p.3260-3263, 2021

  6. The use and impact of mHealth by community health workers in developing and least developed countries: a systematic review

    RESEARCH ON BIOMEDICAL ENGINEERING, v.37, n.3, p.563-582, 2021

    Purpose: In places without adequate health facilities, community health workers (CHWs) are employed by local governments to help families with health promotion activities. However, amidst the difficulties, mobile health applications (mHealth) are being increasingly developed in order to facilitat...

  7. Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective study

    LANCET RHEUMATOLOGY, v.4, n.2, p.E113-E124, 2022

    Background We aimed to examine the immunogenicity pattern induced by the inactivated SARS-CoV-2 vaccine CoronaVac (Sinovac Life Sciences, Beijing, China) in SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases compared with seropositive controls, seronegative patients with autoimmu...

  8. Influenza A/Singapore (H3N2) component vaccine in systemic lupus erythematosus: A distinct pattern of immunogenicity

    LUPUS, v.30, n.12, p.1915-1922, 2021

    Introduction Influenza A (H3N2) virus is the most important cause of seasonal influenza morbidity and mortality in the last 50 years, surpassing the impact of H1N1. Data assessing immunogenicity and safety of this virus component are lacking in systemic lupus erythematosus (SLE) and restricted to...

  9. An Open-label Randomized Controlled Parallel-group Pilot Study Comparing the Immunogenicity of a Standard-, Double-, and Booster-dose Regimens of the 2014 Seasonal Trivalent Inactivated Influenza Vaccine in Kidney Transplant Recipients

    TRANSPLANTATION, v.106, n.1, p.210-220, 2022

    Background. Immunogenicity of influenza vaccine in transplant recipients is suboptimal and alternative vaccination regimens are necessary. Methods. We compared the immunogenicity of a standard-dose trivalent inactivated influenza vaccination (SDTIIV), double-dose trivalent inactivated influenza v...

  10. Evaluation of antimicrobial susceptibility testing of Nocardia spp. isolates by broth microdilution with resazurin and spectrophotometry

    BMC MICROBIOLOGY, v.21, n.1, article ID 331, 8p, 2021

    Background Nocardia species are ubiquitous in natural environments and can cause nocardiosis. In the present study, the use of Resazurin salt and Spectrophotometry were proposed as alternative methods to reduce subjectivity in the interpretation of susceptibility results to antimicrobials by the ...