LIM/52 - Laboratório de Virologia

O Laboratório de Virologia é ligado ao Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: infecções virais em pacientes imunodeprimidos; epidemiologia molecular das doenças virais; desenvolvimento e avaliação de métodos de métodos para diagnóstico de infecções virais; avaliação de vacinas em saúde pública; inquéritos soroepidemiológicos de infecções virais.

Site oficial:


Recent Submissions

  1. Is 0.5% hydrogen peroxide effective against SARS-CoV-2?

    ORAL DISEASES, v.28, suppl.1, p.937-939, 2022

  2. Expression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma


    Objective: Besides angiotensin converting enzyme 2 (ACE2), an active involvement of proteases (FURIN and/or TMPRSS2) is important for cellular entry of SARS-CoV-2. Therefore, a simultaneous expression profiling of entry proteins in a tissue might provide a better risk assessment of SARS-CoV-2 inf...

  3. Assessment of bone metabolism biomarkers in serum and saliva of cirrhotic patients

    CLINICAL ORAL INVESTIGATIONS, v.26, n.2, p.1861-1868, 2022

    Objective To assess the serum and salivary levels of biomarkers related to bone metabolism in cirrhotic patients as well as the evidence of osteoporotic changes on panoramic radiographs. Materials and methods Thirty-eight cirrhotic patients underwent anamnesis and physical examination. Specimens ...

  4. Human endogenous retrovirus and multiple sclerosis: A review and transcriptome findings

    MULTIPLE SCLEROSIS AND RELATED DISORDERS, v.57, article ID 103383, 7p, 2022

    Multiple Sclerosis is an autoimmune disease with an unknown etiology. Both genetic and environmental factors are believed to trigger MS autoimmunity. Among the environmental factors, infectious agents have been extensively investigated, and the Human Endogenous Retroviruses (HERVs), especially HE...

  5. Fake news and covid-19: a concern due to the low vaccine coverage in Brazil

    SAUDE E SOCIEDADE, v.31, n.1, article ID e210298, 11p, 2022

    This study comprised the application of a survey in Sao Paulo, Brazil, in 2 different periods of 2020: the beginning of the covid-19 pandemic and the disease's first peak (from March to April, 100 interviews) to the time of stability in case fatality rates (from May to July, 100 interviews); the ...

  6. Clinical features of COVID-19 by SARS-CoV-2 Gamma variant: A prospective cohort study of vaccinated and unvaccinated healthcare workers

    JOURNAL OF INFECTION, v.84, n.2, p.262-265, 2022

  7. Generation of neutralizing antibodies against Omicron, Gamma and Delta SARS-CoV-2 variants following CoronaVac vaccination


    Vaccination is a fundamental tool to prevent SARS-CoV-2 infection and to limit the COVID-19 pandemic. The emergence of SARS-CoV-2 variants with multiple mutations has raised serious concerns about the ability of neutralizing antibody responses elicited by prior vaccination to effectively combat t...

  8. MALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-19

    JOURNAL OF ORAL MICROBIOLOGY, v.14, n.1, article ID 2043651, 12p, 2022

    Background The SARS-CoV-2 infections are still imposing a great public health challenge despite the recent developments in vaccines and therapy. Searching for diagnostic and prognostic methods that are fast, low-cost and accurate are essential for disease control and patient recovery. The MALDI-T...

  9. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4(+) T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy

    FRONTIERS IN MEDICINE, v.8, article ID 809312, 6p, 2022

    IntroductionTorque teno virus (TTV) is a non-pathogenic virus present in body fluids. Its titer in the circulation increases in association with immune suppression, such as in HIV-infected individuals. We evaluated if the TTV titer in saliva from HIV-positive individuals undergoing antiretroviral...

  10. Micro-Fourier-transform infrared reflectance spectroscopy as tool for probing IgG glycosylation in COVID-19 patients

    SCIENTIFIC REPORTS, v.12, n.1, article ID 4269, 13p, 2022

    It has been reported that patients diagnosed with COVID-19 become critically ill primarily around the time of activation of the adaptive immune response. However the role of antibodies in the worsening of disease is not obvious. Higher titers of anti-spike immunoglobulin IgG1 associated with low ...