LIM/52 - Laboratório de Virologia

O Laboratório de Virologia é ligado ao Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: infecções virais em pacientes imunodeprimidos; epidemiologia molecular das doenças virais; desenvolvimento e avaliação de métodos de métodos para diagnóstico de infecções virais; avaliação de vacinas em saúde pública; inquéritos soroepidemiológicos de infecções virais.

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Recent Submissions

  1. Latent and active tuberculosis infection in allogeneic hematopoietic stem cell transplant recipients: a prospective cohort study

    BONE MARROW TRANSPLANTATION, v.56, n.9, p.2241-2247, 2021

    Tuberculosis (TB) is a major infectious complication in hematopoietic stem cell transplant (HSCT) recipients in countries with high TB prevalence. Identifying and treating latent tuberculosis infection (LTBI) helps to prevent TB reactivation after transplantation. Few studies have compared the tu...

  2. Low prevalence of human gammaherpesvirus 8 (HHV-8) infection among HIV-infected pregnant women in Rio De Janeiro, Brazil

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, v.34, n.20, p.3458-3461, 2021

    Pregnant women coinfected with the human immunodeficiency virus (HIV) and human gammaherpesvirus 8 (HHV-8) are at higher risk of Kaposi's sarcoma development, increased viral load, and vertical transmission of these viruses. A total of 131 pregnant women infected with HIV were examined for antibo...

  3. Oral shedding of CMV and HSV-1 in hematopoietic stem cell transplantation patients

    ORAL DISEASES, v.27, n.6, p.1572-1579, 2021

    Objectives To evaluate the oral shedding of herpesviruses in patients undergoing hematopoietic stem cell transplantation (HSCT) and correlate it with oral mucositis (OM). Methods Saliva samples were collected before the HSCT and on day D + 8. Multiplex Polymerse Chain Reaction (PCR) was performed...

  4. Frequency and Evolution of Acute Oral Complications in Patients Undergoing Radiochemotherapy Treatment for Head and Neck Squamous Cell Carcinoma

    ENT-EAR NOSE & THROAT JOURNAL, v.100, n.5_SUPPL, suppl.5_, p.449S-455S, 2021

    Despite its effectiveness, radiochemotherapy treatment in the head and neck region is accompanied by acute oral complications such as oral mucositis, dysphagia, xerostomia, and dysgeusia. The aim of this study was to analyze and prospectively assess the frequency and evolution of acute oral compl...

  5. Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services

    BMJ OPEN, v.11, n.7, article ID e045852, 7p, 2021

    Introduction Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute he...

  6. Lock or Down: Effectiveness of Isolation Measures Against COVID-19

    CLINICS, v.76, article ID e3218, 3p, 2021

  7. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence and Risk Factors Among Oligo/Asymptomatic Healthcare Workers: Estimating the Impact of Community Transmission

    CLINICAL INFECTIOUS DISEASES, v.73, n.5, p.E1214-E1218, 2021

    We evaluated the seroprevalence of SARS-CoV-2 and risk factors among 4987 oligo/asymptomatic healthcare workers; seroprevalence was 14% and factors associated with SARS-CoV-2 infection were lower educational level (aOR, 1.93; 95% CI, 1.03-3.60), using public transport to work (aOR, 1.65; 95% CI, ...

  8. Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?

    PLOS ONE, v.16, n.8, article ID e0256357, 9p, 2021

    Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopha...

  9. A Novel Saliva RT-LAMP Workflow for Rapid Identification of COVID-19 Cases and Restraining Viral Spread

    DIAGNOSTICS, v.11, n.8, article ID 1400, 19p, 2021

    Rapid diagnostics is pivotal to curb SARS-CoV-2 transmission, and saliva has emerged as a practical alternative to naso/oropharyngeal (NOP) specimens. We aimed to develop a direct RT-LAMP (reverse transcription loop-mediated isothermal amplification) workflow for viral detection in saliva, and to...

  10. SARS-Cov-2 seroprevalence and risk factors among health care workers: Estimating the risk of COVID-19 dedicated units

    AMERICAN JOURNAL OF INFECTION CONTROL, v.49, n.9, p.1197-1199, 2021

    We evaluated the seroprevalence of SARS-CoV-2 and risk factors among 1,996 oligo/asymptomatic health care workers. The seroprevalence was 5.5% and risk factors associated with being infected with SARS-CoV-2 was professional category of cleaning (adj odds ratio 2.22, 95% confidence interval: 1.12-...