LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências

O Laboratório de Investigação em Dermatologia e Imunodeficiências é ligado ao Departamento de Dermatologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: dermatoses infecciosas e parasitárias; imunodermatologia; imunologia viral; imunomodulação experimental; imunopatologia da infecção pelo HIV; imunopatologia das imunodeficiências primárias; imunopatologia das imunodeficiências secundárias, infecciosas ou metabólicas; imunopatologia das infecções primárias; imunorregulação; retrovirose humana.

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Recent Submissions

  1. Patient with agammaglobulinemia produces anti-SARS-CoV-2 reactive T-cells after CoronaVac vaccine

    CLINICS, v.77, article ID 100007, 2p, 2022

  2. Immunology of leprosy

    INTERNATIONAL REVIEWS OF IMMUNOLOGY, v.41, n.2, p.72-83, 2022

    Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical manifestations, which are strongly correlated with the host's immune response. Skin lesions may be accompanied by peripheral neural damage, leading to sensory and motor losses, as well as deformities of the hands and f...

  3. Antiviral Response Induced by Toll-Like Receptor (TLR) 7/TLR8 Activation Inhibits Human Immunodeficiency Virus Type 1 Infection in Cord Blood Macrophages

    JOURNAL OF INFECTIOUS DISEASES, v.225, n.3, p.510-519, 2022

    Cord blood macrophages are more susceptible to HIV-1 infection. This vulnerability can be reversed under treatment with the type I interferon adjuvant CL097, which triggers inflammatory and antiviral responses in these cells, attenuating viral replication. Vertical transmission is the main mechan...

  4. Clinical features of COVID-19 by SARS-CoV-2 Gamma variant: A prospective cohort study of vaccinated and unvaccinated healthcare workers

    JOURNAL OF INFECTION, v.84, n.2, p.262-265, 2022

  5. Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults

    IMMUNITY & AGEING, v.19, n.1, article ID 9, 16p, 2022

    Background COPD is associated with an abnormal lung immune response that leads to tissue damage and remodeling of the lung, but also to systemic effects that compromise immune responses. Cigarette smoking also impacts on innate and adaptative immune responses, exerting dual, pro- and anti-inflamm...

  6. Esophageal Lichen Planus

    JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, v.26, n.2, p.220-220, 2022

  7. Some Good and Some Bad: Sand Fly Salivary Proteins in the Control of Leishmaniasis and in Autoimmunity


    Sand flies are hematophagous insects responsible for the transmission of vector-borne diseases to humans. Prominent among these diseases is Leishmaniasis that affects the skin and mucous surfaces and organs such as liver and spleen. Importantly, the function of blood-sucking arthropods goes beyon...

  8. Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital

    ANAIS BRASILEIROS DE DERMATOLOGIA, v.97, n.1, p.14-21, 2022

    Background: Mucocutaneous adverse events are common during anticancer treatment, with variable consequences for the patient and their therapeutic regimen. Objective: To evaluate the most common adverse events, as well as the drugs associated with their appearance and the consequences for cancer t...

  9. Deciphering the influence of smoking in adults with atopic dermatitis


  10. Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone

    EXPERIMENTAL DERMATOLOGY, v.31, n.2, p.191-201, 2022

    Background Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) are among the most common skin sensitizers, yet the immunological events that occur during MCI/MI allergic contact dermatitis (ACD) are still poorly understood. Objectives: To analyse dendrocytes, macrophage subtypes and ...