LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

O Laboratório de Ginecologia Estrutural e Molecular é ligado ao Departamento de Obstetrícia e Ginecologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: repercussões bioquímicas, metabólicas e clínicas das diversas modalidades terapêuticas no climatério; abordagem translacional da síndrome dos ovários policísticos; estudo das alterações endometriais na saúde reprodutiva feminina; aspectos moleculares e terapêuticos do câncer genital e mamário; marcadores bioquímicos, imunológicos e moleculares e sua relação com a endometriose peritoneal, de ovário e profunda.

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Recent Submissions

  1. Histological response and expression of collagen, metalloproteinases MMP-1 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 in fetal membranes following open intrauterine surgery: an experimental study

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, v.35, n.7, p.1301-1309, 2022

    Objective: To characterize aspects of the repair process by evaluating the tissue collagen density, metalloproteinases and tissue inhibitor of matrix metalloproteinases in the fetal membranes following open fetal surgery for myelomeningocele (MMC). Design: Experimental. Setting: Two Brazilian hos...

  2. Comparative measurement of D- and L-lactic acid isomers in vaginal secretions: association with high-grade cervical squamous intraepithelial lesions

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, v.305, n.2, p.373-377, 2022

    Purpose Identification of low-cost protocols to identify women at elevated susceptibility to develop cervical intra-epithelial abnormalities would aid in more individualized monitoring. We evaluated whether quantitation of the D- and L-lactic acid isomers in vaginal secretions could differentiate...

  3. Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study

    JMIR RESEARCH PROTOCOLS, v.10, n.11, article ID e28032, 9p, 2021

    Background: Studies evaluating cosmetic gynecological interventions have followed variable methodology and reported a diversity of outcomes. Such variations limit the comparability of studies and the value of research-based evidence. The development of core outcome sets (COS) and core outcome mea...

  4. The contexts of science journalism in the Brazilian Federal Institutes: characterizing realities and possibilities of communication products

    HELIYON, v.8, n.1, article ID e08701, 12p, 2022

    A public teaching and research institution can also be recognized for its scientific projection in society, as well as for interfering directly or indirectly in social dynamics through science. In this sense, this study intends to analyze how science communication is inserted in the communication...

  5. Depressive Symptoms and Their Associated Factors in Vocational-Technical School Students during the COVID-19 Pandemic


    The objectives of this study were to compare the prevalence of depressive symptoms, behavioral habits, and QoL in students from two vocational-technical schools, and to determine the association of depressive symptoms with behavioral habits and quality of life (QoL) in these students during the C...

  6. Evaluation of Hedgehog Pathway Inhibitors as a Therapeutic Option for Uterine Leiomyosarcoma Using the Xenograft Model

    REPRODUCTIVE SCIENCES, v.29, n.3, p.781-790, 2022

    Uterine leiomyosarcoma (LMS) contributes to a significant proportion of uterine cancer deaths. It is a rare and high-risk gynecological cancer. LMS is challenging to the treatment due to the resistance of several therapies. The activation of the Hedgehog (HH) pathway has been reported in several ...

  7. Hyaluronic acid and proliferation/cellular death amount in the female rats mammary gland after estroprogestative therapy

    GYNECOLOGICAL ENDOCRINOLOGY, v.38, n.2, p.181-185, 2022

    Aims To evaluate the concentration of hyaluronan acid and proliferation/cellular death in mammary gland of ovariectomized female rat after estroprogestative therapy. Materials and methods Forty ovariectomized female rats were divided into four groups with 10 animals/each: OG (vehicle); EG: (Estra...

  8. Effectivity of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) when male factor is absent: a perspective point of view


    An objective and individualized approach of in vitro fertilization techniques tends to decrease costs and improve the experience of infertile couples during treatment. The use of available technologies to diagnose and treat infertility based on scientific evidence seems to be the best practice, w...

  9. Endometriosis classification systems: an international survey to map current knowledge and uptake(dagger)(double dagger)

    HUMAN REPRODUCTION OPEN, v.2022, n.1, article ID hoac002, 12p, 2022

    STUDY QUESTION Which classification system for endometriosis do clinicians use most frequently, and why? SUMMARY ANSWER Even with a high uptake of the three existing endometriosis classification systems, most clinicians managing endometriosis would like a new simple surgical descriptive system fo...

  10. Full and empty nest syndromes in women in the climacteric period

    REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, v.68, n.1, p.109-117, 2022