LIM/59 - Laboratório de Biologia Celular

O Laboratório de Biologia Celular é ligado ao Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: sistema reprodutor: estudo experimental das alterações fisiopatológicas da função reprodutiva; sistema respiratório: estudo do remodelamento pulmonar e dos mecanismos de defesa pulmonar; sistema cardiovascular: estudo experimental dos mecanismos controle da pressão arterial. Temas gerais: biopatologia da matriz extracelular; aplicação de métodos morfométricos ao estudo do remodelamento tecidual; ultraestrutura e função celular.

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Envíos recientes

  1. Hypertension and Exercise Training: Evidence from Clinical Studies


    Hypertension is a worldwide prevalent disease, mostly manifested as its primary ethiology, characterized by a chronic, multifactorial, asymptomatic, and usually incurable state. It is estimated that more than one billion of the world population is hypertensive. Also, hypertension is the main caus...

  2. Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects

    FRONTIERS IN PHYSIOLOGY, v.13, article ID 812942, 11p, 2022

    AimsBoth postprandial lipemia (PPL) and disturbed blood flow (DBF) induce endothelial dysfunction. However, the interactive effect of these stimuli on endothelial function is currently unknown. In the present study, we tested whether PPL plus DBF causes a greater reduction in flow-mediated dilati...

  3. Randomized trials of therapeutic heparin for COVID-19: A meta-analysis

    RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, v.5, n.8, article ID e12638, 9p, 2021

    Background: Pulmonary endothelial injury and microcirculatory thromboses likely contribute to hypoxemic respiratory failure, the most common cause of death, in patients with COVID-19. Randomized controlled trials (RCTs) suggest differences in the effect of therapeutic heparin between moderately a...

  4. Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.32, n.7, p.1616-1629, 2021

    Background SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested the hypothesis that the SGLT2 inhibitor empagliflozi...

  5. Left Ventricle Dysfunction is Prevented by the Treatment With Methotrexate Carried in Lipid Nanoparticles in Lipopolysaccharide-injected Rats

    CIRCULATION, v.142, suppl.3, 2020

  6. Methotrexate Carried in Lipid Core Nanoparticles Prevented the Dilation and Dissection of the Aortic Arch in Mice With Marfan Syndrome by Increasing the Bioavailability of Intracellular Adenosine

    CIRCULATION, v.142, suppl.3, 2020

  7. Aerobic Exercise Improves Asthma Phenotype in a Model of Severe Asthma: Involvement of Kinins

    EUROPEAN RESPIRATORY JOURNAL, v.58, suppl.65, 2021

  8. Testicular pathology in fatal COVID-19: A descriptive autopsy study

    ANDROLOGY, v.10, n.1, p.13-23, 2022

    Background Multi-organ damage is a common feature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, going beyond the initially observed severe pneumonia. Evidence that the testis is also compromised is growing. Objective To describe the pathological findings in testes fro...

  9. Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020

    CLINICAL INFECTIOUS DISEASES, v.73, suppl.5, p.S442-S453, 2021

    Background: Minimally invasive autopsies, also known as minimally invasive tissue sampling (MITS), have proven to be an alternative to complete diagnostic autopsies (CDAs) in places or situations where this procedure cannot be performed. During the coronavirus disease 2019 (COVID-19) pandemic, CD...

  10. Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial

    BMJ-BRITISH MEDICAL JOURNAL, v.375, article ID n2400, 11p, 2021

    OBJECTIVE To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN Randomised controlled, adaptive, open label clinical trial. SETTING 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, Uni...