LIM/59 - Laboratório de Biologia Celular
Colecciones en esta comunidad
Hypertension and Exercise Training: Evidence from Clinical Studies
EXERCISE FOR CARDIOVASCULAR DISEASE PREVENTION AND TREATMENT: FROM MOLECULAR TO CLINICAL, PT 2, v.1000, p.65-84, 2017
Hypertension is a worldwide prevalent disease, mostly manifested as its primary ethiology, characterized by a chronic, multifactorial, asymptomatic, and usually incurable state. It is estimated that more than one billion of the world population is hypertensive. Also, hypertension is the main caus...
Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects
FRONTIERS IN PHYSIOLOGY, v.13, article ID 812942, 11p, 2022
AimsBoth postprandial lipemia (PPL) and disturbed blood flow (DBF) induce endothelial dysfunction. However, the interactive effect of these stimuli on endothelial function is currently unknown. In the present study, we tested whether PPL plus DBF causes a greater reduction in flow-mediated dilati...
Randomized trials of therapeutic heparin for COVID-19: A meta-analysis
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, v.5, n.8, article ID e12638, 9p, 2021
Background: Pulmonary endothelial injury and microcirculatory thromboses likely contribute to hypoxemic respiratory failure, the most common cause of death, in patients with COVID-19. Randomized controlled trials (RCTs) suggest differences in the effect of therapeutic heparin between moderately a...
Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.32, n.7, p.1616-1629, 2021
Background SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested the hypothesis that the SGLT2 inhibitor empagliflozi...
Left Ventricle Dysfunction is Prevented by the Treatment With Methotrexate Carried in Lipid Nanoparticles in Lipopolysaccharide-injected Rats
CIRCULATION, v.142, suppl.3, 2020
Methotrexate Carried in Lipid Core Nanoparticles Prevented the Dilation and Dissection of the Aortic Arch in Mice With Marfan Syndrome by Increasing the Bioavailability of Intracellular Adenosine
CIRCULATION, v.142, suppl.3, 2020
Aerobic Exercise Improves Asthma Phenotype in a Model of Severe Asthma: Involvement of Kinins
EUROPEAN RESPIRATORY JOURNAL, v.58, suppl.65, 2021
Testicular pathology in fatal COVID-19: A descriptive autopsy study
ANDROLOGY, v.10, n.1, p.13-23, 2022
Background Multi-organ damage is a common feature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, going beyond the initially observed severe pneumonia. Evidence that the testis is also compromised is growing. Objective To describe the pathological findings in testes fro...
Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020
CLINICAL INFECTIOUS DISEASES, v.73, suppl.5, p.S442-S453, 2021
Background: Minimally invasive autopsies, also known as minimally invasive tissue sampling (MITS), have proven to be an alternative to complete diagnostic autopsies (CDAs) in places or situations where this procedure cannot be performed. During the coronavirus disease 2019 (COVID-19) pandemic, CD...
Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
BMJ-BRITISH MEDICAL JOURNAL, v.375, article ID n2400, 11p, 2021
OBJECTIVE To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN Randomised controlled, adaptive, open label clinical trial. SETTING 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, Uni...