LIM/62 - Laboratório de Investigação Médica em Neurocirurgia

O Laboratório de Investigação Médica em Neurocirurgia é ligado ao Departamento Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP). Denominado Laboratório de Fisiopatologia Cirúrgica e ligado ao Departamento Fisiopatologia Cirúrgica até o ano de 2019 com produção científica até o ano de 2018.

Linhas de pesquisa: medicina, com ênfase em neurocirurgia e atua principalmente nos seguintes temas: dor, dor aguda, dor crônica, dor neuropática e síndrome dolorosa miofascial, neurocirurgia, cirurgia para movimentos anormais, espasticidade, doenças da coluna vertebral e tumores do sistema nervoso; validação psicométrica e tradução de instrumentos de rastreio e caracterização de síndromes dolorosas e seus aspectos; excitabilidade cortical em doentes com dor crônica, uso de neuromodulação não invasiva em dor; profilaxia de dor neuropática em doentes com câncer; uso de neuromodulação implantada em dor; dor na doença de Parkinson; hipertensão intracraniana e lesão encefálica; neurotrauma; neuromodulação não invasiva em pacientes e técnicas neurocirúrgicas.

Site oficial:


Recent Submissions

  1. Chronic postoperative orofacial pain. Case reports

    BRJP, v.4, n.2, p.184-187, 2021

    ABSTRACT BACKGROUND AND OBJECTIVES: The presence of neoplasms, chronic and oral diseases may require surgical treatment for its resolution, although it may consequently cause chronic pain. Chronic postoperative orofacial pain remains even after tissue healing and its causes are not defined. Altho...

  2. Eficácia do topiramato como terapia adicional em pacientes com estado epiléptico refratário: uma breve revisão sistemática

    REVISTA BRASILEIRA DE TERAPIA INTENSIVA, v.33, n.3, p.440-444, 2021

    ABSTRACT Objective: To identify current evidence on the use of topiramate for refractory status epilepticus. Methods: We reviewed the literature to investigate the efficacy of topiramate in the treatment of refractory status epilepticus. The search terms used were “status epilepticus”, “refractor...

  3. Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia

    CLINICAL NEUROLOGY AND NEUROSURGERY, v.208, article ID 106880, 6p, 2021

    Subjects: Trigeminal neuralgia is a neuropathic pain characterized by episodes of severe shock-like pain within the distribution of one or more divisions of the trigeminal nerve. Pain can be influenced by ethnicity, environment, gender, psychological traits, and genetics. Molecules Nav1.6 sodium ...

  4. Diagnosis and Management of Pain in Parkinson's Disease: A New Approach

    DRUGS & AGING, v.38, n.7, p.559-577, 2021

    Pain is a frequent and disabling non-motor feature of Parkinson's disease (PD). The recently proposed PD Pain Classification System (PD-PCS) allows for an association of pain with PD to be determined before being allocated to the main pain mechanism (i.e. nociceptive, neuropathic, and nociplastic...

  5. Fields of Forel Brain Stimulation Improves Levodopa-Unresponsive Gait and Balance Disorders in Parkinson's Disease

    NEUROSURGERY, v.89, n.3, p.450-459, 2021

    BACKGROUND: Gait and balance disturbance are challenging symptoms in advanced Parkinson's disease (PD). Anatomic and clinical data suggest that the fields of Forel may be a potential surgical target to treat these symptoms. OBJECTIVE: To test whether bilateral stimulation centered at the fields o...

  6. Mercury Exposure in Munduruku Indigenous Communities from Brazilian Amazon: Methodological Background and an Overview of the Principal Results


    The Amazonian indigenous peoples depend on natural resources to live, but human activities' growing impacts threaten their health and livelihoods. Our objectives were to present the principal results of an integrated and multidisciplinary analysis of the health parameters and assess the mercury (...

  7. Immersive virtual reality in patients with moderate and severe traumatic brain injury: a feasibility study

    HEALTH AND TECHNOLOGY, v.11, n.5, p.1035-1044, 2021

    Background Traumatic brain injury (TBI) remains a global health problem with cognitive impairments that can affect an individual's life. Although there is still no effective treatment for TBI sequelae, virtual reality (VR) technology shows promising results as a training tool to improve cognitive...

  8. Introduction for special issue on pain in developing countries

    PAIN REPORTS, v.4, n.6, 2019

  9. Improvement in neurological outcome and brain hemodynamics after late cranioplasty

    ACTA NEUROCHIRURGICA, v.163, n.10, p.2931-2939, 2021

    Background Early cranioplasty has been encouraged after decompressive craniectomy (DC), aiming to reduce consequences of atmospheric pressure over the opened skull. However, this practice may not be often available in low-middle-income countries (LMICs). We evaluated clinical improvement, hemodyn...

  10. Prevalence of chronic pain in developing countries: systematic review and meta-analysis

    PAIN REPORTS, v.4, n.6, 2019

    Chronic pain (CP) is prevalent worldwide. Current reports on its prevalence in developing countries are heterogeneous, and to date, there is no quantitative synthesis providing a general estimation of its magnitude in the developing world. The goal of this study was to estimate the pooled prevale...