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Title: Claudin expression is maintained in mucoepidermoid carcinoma of the salivary gland
Authors: ARRUDA, Claudia Fabiana Joca deCOUTINHO-CAMILLO, Claudia MalheirosMARQUES, Marcia MartinsNAGANO, Cibele PidorodeskiBOLOGNA, Sheyla BatistaBETTIM, Barbara BeltrameGERMANO, Janaina NaiaraPINTO, Clovis Antonio LopesHSIEH, RicardoLOURENCO, Silvia Vanessa
Citation: PATHOLOGY RESEARCH AND PRACTICE, v.216, n.11, article ID 153161, 8p, 2020
Abstract: Objective: The aim of the present study was to investigate the expression of claudin-1,-3,-4,-5 and-7 proteins in mucoepidermoid carcinoma of oral cavity and analyze whether EGF may interfere in the expression of the genes that encode claudins using in vitro models. Material and methods: Using immunohistochemistry, the expression of claudins was searched in 36 histologically graded cases of mucoepidermoid carcinoma. The association of expression of claudins with clinical-pathological parameters was evaluated. An in vitro step investigated the influence of EGF on gene expression of claudins by real time RT-PCR technique. Results: Claudin-1,-3,-4,-5, and-7 were highly expressed in most mucoepidermoid carcinomas. These expres-sions were compared with clinicopathological parameters. High expression of claudin-1 was associated with patients over 40 years-old (p = 0.05) and Caucasians (p = 0.024). In vitro experiments demonstrated a tendency for Claudin gene expression increase after EGF stimulus. Conclusions: The expression of claudins is maintained in mucoepidermoid carcinoma cells and EGF could be related with this expression. Our results point out to a fundamental biological importance to CLDNs in normal and neoplastic tissue. The expression patterns of CLDNs does not yet allow a clinical application, but the biological knowledge will ground evidence to new studies towards possible target-therapies.
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