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https://observatorio.fm.usp.br/handle/OPI/38499
Título: | Claudin expression is maintained in mucoepidermoid carcinoma of the salivary gland |
Autor: | ARRUDA, Claudia Fabiana Joca de; COUTINHO-CAMILLO, Claudia Malheiros; MARQUES, Marcia Martins; NAGANO, Cibele Pidorodeski; BOLOGNA, Sheyla Batista; BETTIM, Barbara Beltrame; GERMANO, Janaina Naiara; PINTO, Clovis Antonio Lopes; HSIEH, Ricardo; LOURENCO, Silvia Vanessa |
Citación: | PATHOLOGY RESEARCH AND PRACTICE, v.216, n.11, article ID 153161, 8p, 2020 |
Resumen: | Objective: The aim of the present study was to investigate the expression of claudin-1,-3,-4,-5 and-7 proteins in mucoepidermoid carcinoma of oral cavity and analyze whether EGF may interfere in the expression of the genes that encode claudins using in vitro models. Material and methods: Using immunohistochemistry, the expression of claudins was searched in 36 histologically graded cases of mucoepidermoid carcinoma. The association of expression of claudins with clinical-pathological parameters was evaluated. An in vitro step investigated the influence of EGF on gene expression of claudins by real time RT-PCR technique. Results: Claudin-1,-3,-4,-5, and-7 were highly expressed in most mucoepidermoid carcinomas. These expres-sions were compared with clinicopathological parameters. High expression of claudin-1 was associated with patients over 40 years-old (p = 0.05) and Caucasians (p = 0.024). In vitro experiments demonstrated a tendency for Claudin gene expression increase after EGF stimulus. Conclusions: The expression of claudins is maintained in mucoepidermoid carcinoma cells and EGF could be related with this expression. Our results point out to a fundamental biological importance to CLDNs in normal and neoplastic tissue. The expression patterns of CLDNs does not yet allow a clinical application, but the biological knowledge will ground evidence to new studies towards possible target-therapies. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_ARRUDA_Claudin_expression_is_maintained_in_mucoepidermoid_carcinoma_of_2020.PDF Restricted Access | publishedVersion (English) | 6.26 MB | Adobe PDF | Visualizar/Abrir Request a copy |
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