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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFANG, Marcel
dc.contributor.authorMARTA, Gustavo Nader
dc.identifier.citationREVISTA DA ASSOCIACAO MEDICA BRASILEIRA, v.66, n.9, p.1301-1306, 2020
dc.description.abstractINTRODUCTION: Radiation therapy is widely used as adjuvant treatment in breast cancer patients. In the last decades, several studies have been designed to evaluate the safety and efficacy of hypofractionated breast radiation therapy. More recently, even shorter regimens with doses above 4 Gy (hyper-hypofractionation) have also been proposed. This study aims to present a narrative review of the various hypo fractionation protocols used to treat breast cancer patients with a focus on clinical application. RESULTS: Long-term results from several phase III randomized controlled trials demonstrated the safety and efficacy of hypofractionated breast radiation therapy using 15 or 16 fractions for early and locally advanced disease. The results of the initial clinical trials of hyper-hypofractionation are also encouraging and it is believed that these regimens may become routine in the indication of adjuvant radiation therapy treatment after the ongoing studies on this subject have matured. CONCLUSIONS: The idea that normal tissues could present high toxicity at doses above 2 Gy was opposed by clinical trials that demonstrated that moderate hypo fractionation had similar results regarding oncological and cosmetic outcomes compared to conventional fractionation. Cosmetic and toxicity results from hyper-fractionation studies are in principle favorable. However, the long-term oncological results of studies that used hyper-hypofractionation for the treatment of breast cancer patients are still awaited.eng
dc.relation.ispartofRevista da Associacao Medica Brasileira
dc.subjectRadiation therapyeng
dc.subjectBreast neoplasmseng
dc.subjectRadiation dose hypofractionationeng
dc.subject.otherradiotherapy hypofractionationeng
dc.subject.otheruk standardizationeng
dc.titleHypofractionated and hyper-hypofractionated radiation therapy in postoperative breast cancer treatmenteng
dc.rights.holderCopyright ASSOC MEDICA BRASILEIRAeng
dc.subject.wosMedicine, General & Internaleng
dc.type.versionpublishedVersioneng, Marcel:PreventSenior, Dept Radiooncol, Sao Paulo, SP, Brazil
hcfmusp.publisher.citySAO PAULOeng
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ODS/03 - Saúde e bem-estar

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