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https://observatorio.fm.usp.br/handle/OPI/38522
Título: | Validation of MicroRNA-188-5p Inhibition Power on Tumor Cell Proliferation in Papillary Thyroid Carcinoma |
Autor: | ZHOU, Ping; IRVING, Andrew; WU, Huifang; LUO, Juan; AGUIRRE, Johana; COSTA, Mariana; KHAMSUREE, Monny; GERADS, Natascha; LIU, Weibang |
Citación: | CELL TRANSPLANTATION, v.29, article ID 0963689720918300, 8p, 2020 |
Resumen: | Given the crucial role of microRNAs in the cellular proliferation of various types of cancers, we aimed to analyze the expression and function of a cellular proliferation-associated miR-188-5p in papillary thyroid carcinoma (PTC). Here we demonstrate that miR-188-5p is downregulated in PTC tumor tissues compared with the associated noncancerous tissues. We also validate that the miR-188-5p overexpression suppressed the PTC cancer cell proliferation. In addition, fibroblast growth factor 5 (FGF5) is observed to be downregulated in the PTC tumor tissues compared with the associated noncancerous tissues. Subsequently, FGF5 is identified as the direct functional target of miR-188-5p. Moreover, the silencing of FGF5 was found to inhibit PTC cell proliferation, which is the same pattern as miR-188-5p overexpression. These results suggest that miR-188-5p-associated silencing of FGF5 inhibits tumor cell proliferation in PTC. It also highlights the importance of further evaluating miR-188-5p as a potential biomarker and therapy target in PTC. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - ODS/03 |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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art_ZHOU_Validation_of_MicroRNA1885p_Inhibition_Power_on_Tumor_Cell_2020.PDF.pdf | publishedVersion (English) | 615.69 kB | Adobe PDF | Visualizar/Abrir |
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