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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | ZHOU, Ping | |
dc.contributor.author | IRVING, Andrew | |
dc.contributor.author | WU, Huifang | |
dc.contributor.author | LUO, Juan | |
dc.contributor.author | AGUIRRE, Johana | |
dc.contributor.author | COSTA, Mariana | |
dc.contributor.author | KHAMSUREE, Monny | |
dc.contributor.author | GERADS, Natascha | |
dc.contributor.author | LIU, Weibang | |
dc.date.accessioned | 2020-12-16T14:57:19Z | - |
dc.date.available | 2020-12-16T14:57:19Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | CELL TRANSPLANTATION, v.29, article ID 0963689720918300, 8p, 2020 | |
dc.identifier.issn | 0963-6897 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/38522 | - |
dc.description.abstract | Given the crucial role of microRNAs in the cellular proliferation of various types of cancers, we aimed to analyze the expression and function of a cellular proliferation-associated miR-188-5p in papillary thyroid carcinoma (PTC). Here we demonstrate that miR-188-5p is downregulated in PTC tumor tissues compared with the associated noncancerous tissues. We also validate that the miR-188-5p overexpression suppressed the PTC cancer cell proliferation. In addition, fibroblast growth factor 5 (FGF5) is observed to be downregulated in the PTC tumor tissues compared with the associated noncancerous tissues. Subsequently, FGF5 is identified as the direct functional target of miR-188-5p. Moreover, the silencing of FGF5 was found to inhibit PTC cell proliferation, which is the same pattern as miR-188-5p overexpression. These results suggest that miR-188-5p-associated silencing of FGF5 inhibits tumor cell proliferation in PTC. It also highlights the importance of further evaluating miR-188-5p as a potential biomarker and therapy target in PTC. | eng |
dc.language.iso | eng | |
dc.publisher | SAGE PUBLICATIONS INC | eng |
dc.relation.ispartof | Cell Transplantation | |
dc.rights | openAccess | eng |
dc.subject | miR-188-5p | eng |
dc.subject | FGF5 | eng |
dc.subject | cell proliferation | eng |
dc.subject.other | targeting fgf5 | eng |
dc.subject.other | cancer | eng |
dc.subject.other | growth | eng |
dc.subject.other | metastasis | eng |
dc.subject.other | autocrine | eng |
dc.subject.other | invasion | eng |
dc.title | Validation of MicroRNA-188-5p Inhibition Power on Tumor Cell Proliferation in Papillary Thyroid Carcinoma | eng |
dc.type | article | eng |
dc.rights.holder | Copyright SAGE PUBLICATIONS INC | eng |
dc.identifier.doi | 10.1177/0963689720918300 | |
dc.identifier.pmid | 32425116 | |
dc.subject.wos | Cell & Tissue Engineering | eng |
dc.subject.wos | Medicine, Research & Experimental | eng |
dc.subject.wos | Transplantation | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | ZHOU, Ping:Hainan Med Coll, Dept Clin Lab, Affiliated Hosp 1, Haikou, Hainan, Peoples R China | |
hcfmusp.author.external | IRVING, Andrew:Univ Texas Austin, Dept Life Sci, Med Sch, Austin, TX 78712 USA | |
hcfmusp.author.external | WU, Huifang:Wuhan Iron & Steel Grp, Med Dept, Hosp 2, Wuhan, Peoples R China | |
hcfmusp.author.external | LUO, Juan:Wuhan Iron & Steel Grp, Med Dept, Hosp 2, Wuhan, Peoples R China | |
hcfmusp.author.external | AGUIRRE, Johana:Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo, Brazil | |
hcfmusp.author.external | KHAMSUREE, Monny:Univ Tubingen, Dept Biol, Tubingen, Germany | |
hcfmusp.author.external | GERADS, Natascha:Univ Tubingen, Dept Biol, Tubingen, Germany | |
hcfmusp.author.external | LIU, Weibang:Wuhan Iron & Steel Grp, Med Dept, Hosp 2, Wuhan, Peoples R China | |
hcfmusp.description.articlenumber | 0963689720918300 | |
hcfmusp.description.volume | 29 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000573455300042 | |
hcfmusp.origem.id | 2-s2.0-85084787755 | |
hcfmusp.publisher.city | THOUSAND OAKS | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1555-3892 | |
hcfmusp.citation.scopus | 6 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_ZHOU_Validation_of_MicroRNA1885p_Inhibition_Power_on_Tumor_Cell_2020.PDF.pdf | publishedVersion (English) | 615.69 kB | Adobe PDF | View/Open |
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