Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/3887
Title: Vaccine-Induced Gag-Specific T Cells Are Associated With Reduced Viremia After HIV-1 Infection
Authors: JANES, HollyFRIEDRICH, David P.KRAMBRINK, AmySMITH, Rebecca J.KALLAS, Esper G.HORTON, HelenCASIMIRO, Danilo R.CARRINGTON, MaryGERAGHTY, Daniel E.GILBERT, Peter B.MCELRATH, M. JulianaFRAHM, Nicole
Citation: JOURNAL OF INFECTIOUS DISEASES, v.208, n.8, p.1231-1239, 2013
Abstract: The contribution of host T-cell immunity and HLA class I alleles to the control of human immunodeficiency virus (HIV-1) replication in natural infection is widely recognized. We assessed whether vaccine-induced T-cell immunity, or expression of certain HLA alleles, impacted HIV-1 control after infection in the Step MRKAd5/HIV-1 gag/pol/nef study. Vaccine-induced T cells were associated with reduced plasma viremia, with subjects targeting >= 3 gag peptides presenting with half-log lower mean viral loads than subjects without Gag responses. This effect was stronger in participants infected proximal to vaccination and was independent of our observed association of HLA-B(star)27, -B(star)57 and -B(star)58:01 alleles with lower HIV-1 viremia. These findings support the ability of vaccine-induced T-cell responses to influence postinfection outcome and provide a rationale for the generation of T-cell responses by vaccination to reduce viremia if protection from acquisition is not achieved. Clinical trials identifier: NCT00095576.
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/60
LIM/60 - Laboratório de Imunologia Clínica e Alergia


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