Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/3893
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorNUNES, Valeria S.-
dc.contributor.authorLEANCA, Camila C.-
dc.contributor.authorPANZOLDO, Natalia B.-
dc.contributor.authorPARRA, Eliane-
dc.contributor.authorZAGO, Vanessa-
dc.contributor.authorCAZITA, Patricia M.-
dc.contributor.authorNAKANDAKARE, Edna R.-
dc.contributor.authorFARIA, Eliana C. de-
dc.contributor.authorQUINTAO, Eder C. R.-
dc.date.accessioned2014-01-28T22:17:16Z-
dc.date.available2014-01-28T22:17:16Z-
dc.date.issued2013-
dc.identifier.citationCLINICAL BIOCHEMISTRY, v.46, n.15, p.1619-1621, 2013-
dc.identifier.issn0009-9120-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3893-
dc.description.abstractSterol 27-hydroxylase converts cholesterol to 27-hydroxycholesterol (27-OHC) which is widely distributed among tissues and is expressed at high levels in the vascular endothelium and macrophages. There is a continuous flow of this oxysterol from the tissues into the liver; where it is converted to bile acids. Objective: Measure plasma concentrations of 27-OHC in subjects that differ according to their plasma HDL-C concentration. Methods: Healthy men presenting low HDL-C (<1,03 mmol/L), n = 18 or high HDL-C (>1.55 mmol/L), n 18, BMI <30 kg/m(2) were recruited after excluding secondary causes that might interfere with their plasma lipid concentrations such as smoking, heavy drinking and diabetes. Blood samples were drawn after a 12 h fasting period for the measurement of 27-OHC by the combined GC/MS analysis utilizing deuterium-label internal standards. Results: The plasma ratio 27-OHC/total cholesterol (median and range nmoL/mmoL) was 50.41 (27.47-116.00) in the High HDL-C subjects and 6334 (36.46-91.18) in the Low HDL-C subjects (p = 0.0258). Conclusion: Our data indicate that the production of 27-0HC by extrahepatic tissues and its transport to the liver may represent an alternative pathway for a deficient reverse cholesterol transport system when plasma HDL-C is low.-
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation) [2010/52654-6]-
dc.description.sponsorshipUniversity of Sao Paulo, Faculty of Medical Sciences, Hospital das Clinicas, Medical Investigation Laboratories [FMUSP-HC/LIMs]-
dc.language.isoeng-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.relation.ispartofClinical Biochemistry-
dc.rightsrestrictedAccess-
dc.subject27-Hydroxycholesterol-
dc.subjectHDL-C-
dc.subjectHuman plasma-
dc.subjectReverse cholesterol transport-
dc.subject.otherelimination-
dc.subject.othertransport-
dc.subject.othermechanism-
dc.subject.othersterols-
dc.subject.otherserum-
dc.titlePlasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects-
dc.typearticle-
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTD-
dc.identifier.doi10.1016/j.clinbiochem.2013.06.025-
dc.identifier.pmid23850851-
dc.subject.wosMedical Laboratory Technology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalPANZOLDO, Natalia B.:State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil-
hcfmusp.author.externalPARRA, Eliane:State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil-
hcfmusp.author.externalZAGO, Vanessa:State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil-
hcfmusp.author.externalFARIA, Eliana C. de:State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil-
hcfmusp.description.beginpage1619-
hcfmusp.description.endpage1621-
hcfmusp.description.issue15-
hcfmusp.description.volume46-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84884356322-
hcfmusp.origem.idWOS:000325056300051-
hcfmusp.publisher.cityOXFORD-
hcfmusp.publisher.countryENGLAND-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipFMUSP-HC-
hcfmusp.citation.scopus4-
hcfmusp.scopus.lastupdate2022-04-28-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/10
LIM/10 - Laboratório de Lípides

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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