Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/39074
Title: A pooled-analysis of age and sex based coronary artery calcium scores percentiles
Authors: RONDE, Maurice W. J. deKHOSHIWAL, AmirPLANKEN, R. NilsBOEKHOLDT, S. MatthijsBIEMOND, MarietteBUDOFF, Matthew J.COOIL, BruceLOTUFO, Paulo A.BENSENOR, Isabela M.OHMOTO-SEKINE, YukiGUDNASON, VilmundurASPELUND, ThorGUDMUNDSSON, Elias FreyrZWINDERMAN, Aeilko H.RAGGI, PaoloPINTO-SIETSMA, Sara-Joan
Citation: JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, v.14, n.5, p.414-420, 2020
Abstract: Background: Age and sex based coronary artery calcium score (CAC) percentiles have been used to improve coronary artery disease (CAD) risk prediction. However, the main limitation of the CACs percentiles currently in use is that they are often based on single studies. We performed a pooled analysis of all available studies that reported on CAC percentiles, in order to develop more generalizable age and sex nomograms. Methods: PubMed/Medline and Embase were searched for studies that reported nomograms of age and sex-based CACs percentiles. Studies were included if they reported data collected among asymptomatic individuals without a history of cardiovascular disease. Absolute CACs for each specific percentile stratum were pooled and new percentiles were generated taking into account the sample size of the study. Results: We found 831 studies, of which 12 met the inclusion criteria. Data on CACs percentiles of 134,336 Western and 33,488 Asians were pooled separately, rendering a weighted CACs percentile nomogram available at https://www.calciumscorecalculator.com Our weighted percentiles differed by up to 24% from the nomograms in use today. Conclusions: Our pooled age and sex based CACs percentiles based on over 155,000 individuals should provide a measure of risk that is more applicable to a wider population than the ones currently in use and hopefully will lead to better risk assessment and treatment decisions.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - LIM/20
LIM/20 - Laboratório de Terapêutica Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_RONDE_A_pooledanalysis_of_age_and_sex_based_coronary_2020.PDFpublishedVersion (English)954.99 kBAdobe PDFThumbnail
View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.