Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/39098
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorGENTA, Pedro R.-
dc.contributor.authorSCHORR, Fabiola-
dc.contributor.authorEDWARDS, Bradley A.-
dc.contributor.authorWELLMAN, Andrew-
dc.contributor.authorLORENZI-FILHO, Geraldo-
dc.date.accessioned2021-02-18T13:27:30Z-
dc.date.available2021-02-18T13:27:30Z-
dc.date.issued2020-
dc.identifier.citationJOURNAL OF CLINICAL SLEEP MEDICINE, v.16, n.9, p.1531-1537, 2020-
dc.identifier.issn1550-9389-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39098-
dc.description.abstractStudy Objectives: Although obstructive sleep apnea results from the combination of different pathophysiologic mechanisms, the degree of anatomical compromise remains the main responsible factor. The passive pharyngeal critical closing pressure (Pcrit) is a technique used to assess the collapsibility of the upper airway and is often used as a surrogate measure of this anatomical compromise. Patients with a low Pcrit (ie, less collapsible airway) are potential candidates for non-continuous positive airway pressure therapies. However, Pcrit determination is a technically complex method not available in clinical practice. We hypothesized that the discrimination between low and high Pcrit can be estimated from simple anthropometric and polysomnographic indices. Methods: Men with and without obstructive sleep apnea underwent Pcrit determination and full polysomnography. Receiver operating characteristics analysis was performed to select the best cutoff of each variable to predict a high Pcrit (Pcrit >= 2.5 cmH(2)O). Multiple logistic regression analysis was performed to create a clinical score to predict a high Pcrit. Results: We studied 81 men, 48 +/- 13 years of age, with an apnea-hypopnea index of 32 [14-60], range 1-96 events/h), and Pcrit of -0.7 +/- 3.1 (range, -9.1 to +7.2 cmH(2)O). A high and low Pcrit could be accurately identified by polysomnographic and anthropometric indices. A score to discriminate Pcrit showed good performance (area under the curve = 0.96; 95% confidence interval, 0.91-1.00) and included waist circumference, non-rapid eye movement obstructive apnea index/apnea-hypopnea index, mean obstructive apnea duration, and rapid eye movement apnea-hypopnea index. Conclusions: A low Pcrit (less collapsible) can be estimated from a simple clinical score. This approach may identify candidates more likely to respond to non-continuous positive airway pressure therapies for obstructive sleep apnea.eng
dc.language.isoeng-
dc.publisherAMER ACAD SLEEP MEDICINEeng
dc.relation.ispartofJournal of Clinical Sleep Medicine-
dc.rightsrestrictedAccesseng
dc.subjectobstructive sleep apneaeng
dc.subjectpharyngeal critical closing pressureeng
dc.subjectpolysomnographyeng
dc.subjectanthropometryeng
dc.subject.otherobstructive sleep-apneaeng
dc.subject.otherupper airway collapsibilityeng
dc.subject.otheroral appliance treatmenteng
dc.subject.othermandibular advancementeng
dc.subject.otherpressureeng
dc.titleDiscriminating the severity of pharyngeal collapsibility in men using anthropometric and polysomnographic indiceseng
dc.typearticleeng
dc.rights.holderCopyright AMER ACAD SLEEP MEDICINEeng
dc.identifier.doi10.5664/jcsm.8600-
dc.identifier.pmid32441245-
dc.subject.wosClinical Neurologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalSCHORR, Fabiola:Univ Sao Paulo, Hosp Clin HCFMUSP, Heart Inst InCor, Lab Sono,Pulm Div, LIM 63, Sao Paulo, Brazil-
hcfmusp.author.externalEDWARDS, Bradley A.:Monash Univ, Dept Physiol, Sleep & Circadian Med Lab, Melbourne, Vic, Australia; Monash Univ, Sch Psychol Sci, Melbourne, Vic, Australia; Monash Univ, Monash Inst Cognit & Clin Neurosci, Melbourne, Vic, Australia-
hcfmusp.author.externalWELLMAN, Andrew:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA-
hcfmusp.description.beginpage1531-
hcfmusp.description.endpage1537-
hcfmusp.description.issue9-
hcfmusp.description.volume16-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000598073400014-
hcfmusp.origem.id2-s2.0-85091127156-
hcfmusp.publisher.cityDARIENeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1550-9397-
hcfmusp.citation.scopus6-
hcfmusp.scopus.lastupdate2022-12-29-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/63
LIM/63 - Laboratório de Investigação Médica em Sono


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