https://observatorio.fm.usp.br/handle/OPI/39247
Title: | Anorexia as the first clinical manifestation of von Hippel-Lindau syndrome |
Authors: | MARQUES, Julia Hatagami; BATISTA, Rafael Loch; MORAES, Mariana Teichner De; MORAIS, Barbara Albuquerque; PINTO, Fernando Campos Gomes; ALMEIDA, Madson Q.; ARAGAO, Denise De Cassia; TEIXEIRA, Manoel Jacobsen; MENDONCA, Berenice B.; CORDAS, Taki Athanassios |
Citation: | MOLECULAR AND CLINICAL ONCOLOGY, v.13, n.5, article ID 65, 4p, 2020 |
Abstract: | Hemangioblastomas (HBs) of the brain may present without neurological symptoms over a long period of time due to their benignity and slow growth. We herein present the case of a female patient who developed a HB of the fourth ventricle presenting only with severe weight loss and anorexia. The patient was screened for mutations in all 3 exons of the VHL gene using Sanger sequencing, and was found to have a nonsense mutation in the VHL gene (single-nucleotide change causing a premature stop codon: c.481C>T; p.Arg161*), causing formation of a truncated protein, consistent with von Hippel-Lindau syndrome (VHLs). The patient was first misdiagnosed with anorexia nervosa (AN) due to the lack of other symptoms. Molecular diagnosis allows further investigation of other VHLs-related tumors and timely, appropriate treatment. However, misdiagnosing anorexia nervosa may lead to poor prognosis and even death; thus, differential diagnosis is crucial in all such cases. The present case report provides evidence that fourth ventricular lesions may affect food intake control and satiety, and highlights the importance of accurate molecular diagnosis. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MNE Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/27 Artigos e Materiais de Revistas Científicas - LIM/42 Artigos e Materiais de Revistas Científicas - LIM/62 |
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art_MARQUES_Anorexia_as_the_first_clinical_manifestation_of_von_2020.PDF Restricted Access | publishedVersion (English) | 398.15 kB | Adobe PDF | View/Open Request a copy |
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