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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MOREIRA, Ricardo P. P. | - |
dc.contributor.author | VILLARES, Sandra M. | - |
dc.contributor.author | MADUREIRA, Guiomar | - |
dc.contributor.author | MENDONCA, Berenice B. | - |
dc.contributor.author | BACHEGA, Tania A. S. S. | - |
dc.date.accessioned | 2014-01-28T22:17:23Z | - |
dc.date.available | 2014-01-28T22:17:23Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | HORMONE RESEARCH IN PAEDIATRICS, v.80, n.2, p.111-118, 2013 | - |
dc.identifier.issn | 1663-2818 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/3933 | - |
dc.description.abstract | Background/Aims: Glucocorticoid (GC) therapy is known to predispose to an adverse metabolic profile. Therefore, we investigated the prevalence of obesity and metabolic syndrome (MetS) in young patients with congenital adrenal hyperplasia (CAH) and to correlate this prevalence with GC treatment and family history. Methods: The study population consisted of 33 young CAH patients who received cortisone acetate during their growth periods; those who were salt wasters also received fludrocortisone. Obesity was defined by a body mass index (BMI) >95th percentile and MetS by the National Cholesterol Education Program Third Adult Treatment Panel modified criteria. Each patient's familial history of MetS components was assessed. The impact of GC therapy on the metabolic profile was analyzed by comparing CAH patients with BMI z-score-matched controls. Results: MetS and obesity were observed in 12.1 and 30.3% of the CAH patients, respectively, both of which were higher than in the reference population. A positive family history of MetS was found to be more prevalent in the obese patients compared with the nonobese CAH patients, and similar findings were observed for the controls. The metabolic profile did not differ between the CAH patients and matched subjects. Conclusion: CAH patients presented a higher prevalence of obesity and MetS, which were not correlated with the GC treatment. This study suggests that obesity and familial predisposition are significant determining factors for an adverse metabolic profile in CAH patients. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/54238-2, 09/54394-4] | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [308318/2012-9, 305743/2011-2] | - |
dc.language.iso | eng | - |
dc.publisher | KARGER | - |
dc.relation.ispartof | Hormone Research in Paediatrics | - |
dc.rights | restrictedAccess | - |
dc.subject | Congenital adrenal hyperplasia | - |
dc.subject | Obesity | - |
dc.subject | Metabolic syndrome | - |
dc.subject | Familial predisposition | - |
dc.subject | Glucocorticoid | - |
dc.subject | Young patients | - |
dc.subject.other | virilizing 21-hydroxylase deficiency | - |
dc.subject.other | insulin-resistance | - |
dc.subject.other | body-composition | - |
dc.subject.other | cardiovascular risk | - |
dc.subject.other | adult patients | - |
dc.subject.other | children | - |
dc.subject.other | adolescents | - |
dc.subject.other | optimize | - |
dc.subject.other | update | - |
dc.subject.other | women | - |
dc.title | Obesity and Familial Predisposition Are Significant Determining Factors of an Adverse Metabolic Profile in Young Patients with Congenital Adrenal Hyperplasia | - |
dc.type | article | - |
dc.rights.holder | Copyright KARGER | - |
dc.identifier.doi | 10.1159/000353762 | - |
dc.identifier.pmid | 23921174 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.subject.wos | Pediatrics | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 111 | - |
hcfmusp.description.endpage | 118 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 80 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000324549400006 | - |
hcfmusp.origem.id | 2-s2.0-84884283647 | - |
hcfmusp.publisher.city | BASEL | - |
hcfmusp.publisher.country | SWITZERLAND | - |
hcfmusp.relation.reference | Abbout DH, 2005, HUM REPROD UPDATE, V11, P357, DOI 10.1093/humupd/dmi013 | - |
hcfmusp.relation.reference | [Anonymous], 1996, PEDIATRICS, V98, P649 | - |
hcfmusp.relation.reference | Arlt W, 2010, J CLIN ENDOCR METAB, V95, P5110, DOI 10.1210/jc.2010-0917 | - |
hcfmusp.relation.reference | Auchus RJ, 2010, CURR OPIN ENDOCRINOL, V17, P210, DOI 10.1097/MED.0b013e32833961d7 | - |
hcfmusp.relation.reference | Bachega TASS, 1998, J CLIN ENDOCR METAB, V83, P4416, DOI 10.1210/jc.83.12.4416 | - |
hcfmusp.relation.reference | Botero D, 2000, METABOLISM, V49, P790, DOI 10.1053/meta.2000.6261 | - |
hcfmusp.relation.reference | Charmandari E, 2002, J CLIN ENDOCR METAB, V87, P2114, DOI 10.1210/jc.87.5.2114 | - |
hcfmusp.relation.reference | Cornean RE, 1998, ARCH DIS CHILD, V78, P261 | - |
hcfmusp.relation.reference | Costa Roberto Fernandes da, 2006, Arq Bras Endocrinol Metabol, V50, P60 | - |
hcfmusp.relation.reference | Dhuper S, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-4 | - |
hcfmusp.relation.reference | Eisner JR, 2000, J CLIN ENDOCR METAB, V85, P1206, DOI 10.1210/jc.85.3.1206 | - |
hcfmusp.relation.reference | Falhammar H, 2011, EUR J ENDOCRINOL, V164, P285, DOI 10.1530/EJE-10-0877 | - |
hcfmusp.relation.reference | Falhammar H, 2007, J CLIN ENDOCR METAB, V92, P110, DOI 10.1210/jc.2006-1350 | - |
hcfmusp.relation.reference | Fernandez JR, 2004, J PEDIATR, V145, P439, DOI 10.1016/j.jpeds.2004.06.044 | - |
hcfmusp.relation.reference | Fernandez-Real JM, 2003, ENDOCR REV, V24, P278, DOI 10.1210/er.2002-0010 | - |
hcfmusp.relation.reference | Gasparini N, 1997, HORM RES, V47, P17, DOI 10.1159/000185361 | - |
hcfmusp.relation.reference | Hagenfeldt K, 2000, EUR J ENDOCRINOL, V143, P667, DOI 10.1530/eje.0.1430667 | - |
hcfmusp.relation.reference | Berenbaum S, 2002, J CLIN ENDOCR METAB, V87, P4048, DOI 10.1210/jc.2002-020611 | - |
hcfmusp.relation.reference | Marti A, 2004, INT J OBESITY, V28, pS29, DOI 10.1038/sj.ijo.0802808 | - |
hcfmusp.relation.reference | Merke DP, 2005, LANCET, V365, P2125, DOI 10.1016/S0140-6736(05)66736-0 | - |
hcfmusp.relation.reference | Mooij CF, 2010, CLIN ENDOCRINOL, V73, P137, DOI 10.1111/j.1365-2265.2009.03690.x | - |
hcfmusp.relation.reference | Moreira RPP, 2011, CLINICS, V66, P1361, DOI 10.1590/S1807-59322011000800009 | - |
hcfmusp.relation.reference | Pasquali R, 2006, FERTIL STERIL, V85, P1319, DOI 10.1016/j.fertnstert.2005.10.054 | - |
hcfmusp.relation.reference | Peeke PM, 1995, ANN NY ACAD SCI, V771, P665, DOI 10.1111/j.1749-6632.1995.tb44719.x | - |
hcfmusp.relation.reference | Reisch N, 2011, HORM RES PAEDIAT, V76, P73, DOI 10.1159/000327794 | - |
hcfmusp.relation.reference | Sartorato P, 2007, J CLIN ENDOCR METAB, V92, P1015, DOI 10.1210/jc.2006-1711 | - |
hcfmusp.relation.reference | Seki M, 2009, PUBLIC HEALTH NUTR, V12, P947, DOI 10.1017/S1368980008003030 | - |
hcfmusp.relation.reference | Silveira EL, 2009, CLIN GENET, V76, P503, DOI 10.1111/j.1399-0004.2009.01274.x | - |
hcfmusp.relation.reference | Snyder EE, 2004, OBES RES, V12, P369, DOI 10.1038/oby.2004.47 | - |
hcfmusp.relation.reference | Speiser PW, 2003, NEW ENGL J MED, V349, P776, DOI 10.1056/NEJMra021561 | - |
hcfmusp.relation.reference | Stikkelbroeck NMML, 2003, J CLIN ENDOCR METAB, V88, P1036, DOI 10.1210/jc.2002-021074 | - |
hcfmusp.relation.reference | van der Sande MAB, 2001, B WORLD HEALTH ORGAN, V79, P321 | - |
hcfmusp.relation.reference | Volkl TMK, 2006, PEDIATRICS, V117, pE98, DOI 10.1542/peds.2005-1005 | - |
hcfmusp.relation.reference | Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697 | - |
hcfmusp.relation.reference | Zhang HJ, 2010, ENDOCRINE, V38, P260, DOI 10.1007/s12020-010-9382-9 | - |
hcfmusp.relation.reference | Zimmermann A, 2010, HORM RES PAEDIAT, V74, P41, DOI 10.1159/000313368 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.citation.scopus | 17 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/25 Artigos e Materiais de Revistas Científicas - LIM/42 Artigos e Materiais de Revistas Científicas - ODS/03 |
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