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Title: IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia
Authors: BECK-DA-SILVA, LuisPIARDI, DiogoSODER, StephanROHDE, Luis EduardoPEREIRA-BARRETTO, Antonio CarlosALBUQUERQUE, Denilson deBOCCHI, EdimarVILAS-BOAS, FabioMOURA, Lidia ZytynzkiMONTERA, Marcelo W.RASSI, SalvadorCLAUSELL, Nadine
Citation: INTERNATIONAL JOURNAL OF CARDIOLOGY, v.168, n.4, p.3439-3442, 2013
Abstract: Background: Anemia in heart failure patients and has been associated with increased morbi-mortality. Previous studies have treated anemia in heart failure patients with either erythropoietin alone or combination of erythropoietin and intravenous (IV) iron. However, the effect of IV or oral (PO) iron supplementation alone in heart failure patients with anemia was virtually unknown. Aim: To compare, in a double-blind design, the effects of IV iron versus PO iron in anemic heart failure patients. Methods: IRON-HF study was a multicenter, investigator initiated, randomized, double-blind, placebo controlled trial that enrolled anemic heart failure patients with preserved renal function, low transferrin saturation (TSat) and low-to-moderately elevated ferritin levels. Interventions were Iron Sucrose IV 200 mg, once a week, for 5 weeks, ferrous sulfate 200 mg PO TID, for 8 weeks, or placebo. Primary endpoint was variation of peak oxygen consumption (peak VO2) assessed by ergospirometry over 3 month follow-up. Results: Eighteen patients had full follow-up data. There was an increment of 3.5 ml/kg/min in peak VO2 in the IV iron group. There was no increment in peak VO2 in the PO iron group. Patients' ferritin and TSat increased significantly in both treated groups. Hemoglobin increased similarly in all groups. Conclusion: IV iron seems to be superior in improving functional capacity of heart failure patients. However, correction of anemia seems to be at least similar between PO iron and IV iron supplementation.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11

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