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Title: Physiological mechanism and spatial distribution of increased alveolar dead-space in early ARDS: An experimental study
Authors: BEDA, AlessandroWINKLER, TiloWELLMAN, Tyler J.PROST, Nicolas DeTUCCI, MauroMELO, Marcos F. Vidal
Citation: ACTA ANAESTHESIOLOGICA SCANDINAVICA, v.65, n.1, p.100-108, 2021
Abstract: Background We aimed to investigate the physiological mechanism and spatial distribution of increased physiological dead-space, an early marker of ARDS mortality, in the initial stages of ARDS. We hypothesized that: increased dead-space results from the spatial redistribution of pulmonary perfusion, not ventilation; such redistribution is not related to thromboembolism (ie, areas with perfusion = 0 and infinite ventilation-perfusion ratio,V/), but rather to moderate shifts of perfusion increasingV/in non-dependent regions. Methods Five healthy anesthetized sheep received protective ventilation for 20 hours, while endotoxin was continuously infused. Maps of voxel-level lung ventilation, perfusion,V/, CO(2)partial pressures, and alveolar dead-space fraction were estimated from positron emission tomography at baseline and 20 hours. Results Alveolar dead-space fraction increased during the 20 hours (+0.05,P = .031), mainly in non-dependent regions (+0.03,P = .031). This was mediated by perfusion redistribution away from non-dependent regions (-5.9%,P = .031), while the spatial distribution of ventilation did not change, resulting in increasedV/in non-dependent regions. The increased alveolar dead-space derived mostly from areas with intermediateV/(0.5 <= V/Q <= 10), not areas of nearly ""complete"" dead-space (V/Q>10). Conclusions In this early ARDS model, increases in alveolar dead-space occur within 20 hours due to the regional redistribution of perfusion and not ventilation. This moderate redistribution suggests changes in the interplay between active and passive perfusion redistribution mechanisms (including hypoxic vasoconstriction and gravitational effects), not the appearance of thromboembolism. Hence, the association between mortality and increased dead-space possibly arises from the former, reflecting gas-exchange inefficiency due to perfusion heterogeneity. Such heterogeneity results from the injury and exhaustion of compensatory mechanisms for perfusion redistribution.
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Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia

Artigos e Materiais de Revistas Científicas - ODS/13
ODS/13 - Ação contra a mudança global do clima

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