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https://observatorio.fm.usp.br/handle/OPI/39599
Title: | Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles |
Authors: | MAIA, Joana; OTAKE, Andreia Hanada; POCAS, Juliana; CARVALHO, Ana Sofia; BECK, Hans Christian; MAGALHAES, Ana; MATTHIESEN, Rune; MORAES, Maria Carolina Strano; COSTA-SILVA, Bruno |
Citation: | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v.8, article ID 592518, 13p, 2020 |
Abstract: | Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b(+) bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b(+) BM cells and induce the expansion of this cell population. Transcriptomic characterization of these cells shows that PC-EVs upregulate IgG and IgA genes, which have been linked to the presence of monocytes/macrophages in tumor microenvironments. We also report here the transcriptional downregulation of genes linked to monocyte/macrophage activation, trafficking, and expression of inflammatory molecules. Together, these results show for the first time the existence of a PC-BM communication axis mediated by EVs with a potential role in PC tumor microenvironments. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
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File | Description | Size | Format | |
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art_MAIA_Transcriptome_Reprogramming_of_CD11b_Bone_Marrow_Cells_by_2020.PDF | publishedVersion (English) | 1.41 MB | Adobe PDF | View/Open |
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