Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/39648
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLYRA DE OLIVEIRA, Tales
dc.contributor.authorCARTAXO DE SOUZA, Tácio Nertan
dc.contributor.authorMARTINS LUCENA, Byron
dc.contributor.authorSANTOS SANTANA, Fernanda Mayara
dc.contributor.authorZAMBRANO, Lysien Ivania
dc.contributor.authorDE CARVALHO ARAUJO, Ana Rose
dc.contributor.authorDE GUSMÃO FREIRE, Ana Lúcia
dc.date.accessioned2021-03-09T21:19:10Z-
dc.date.available2021-03-09T21:19:10Z-
dc.date.issued2020
dc.identifier.citationREVISTA DE LA FACULTAD DE MEDICINA HUMANA, v.20, n.1, p.55-63, 2020
dc.identifier.issn2308-0531
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39648-
dc.description.abstractABSTRACT Objective: To evaluate the histopathological changes present in the lungs and respiratory muscles (diaphragm and ECOM) of the corpses with a diagnosis of COPD. Methods: This is a blind and descriptive study with analysis of histological images of biopsy. The history of smoking associated with the presence of pulmonary anthracosis, septal thickening and emphysematous bullae included the inclusion criteria of the study. The sample consisted of lung, diaphragm and ECOM biopsies. The study was performed by optical microscopic analysis of histological sheets obtained from 36 bodies with COPD. The histopathological diagnosis was made by a pathologist who did not know the objectives of the study. Results: In the diaphragm, there was the presence of interposed adipose tissue, muscular atrophy, removal of muscle fibers and fibrosis. In ECOM, the elimination of muscle fibers, muscular atrophy, interposed adipose tissue, muscle hypertrophy and thickening of the tendons were also evident. Conclusion: The changes found in the diaphragm and ECOM muscle biopsies of the bodies with COPD were evidenced as a mechanism of compensation and / or dysfunction of the respiratory system due to biomechanical alterations promoted by the disease.eng
dc.description.abstractRESUMEN Objetivo: Evaluar los cambios histopatológicos presentes en los pulmones, diafragma y esternocleidomastoideo en cadáveres con diagnóstico de Enfermedad Pulmonar Obstructiva Crónica. Métodos: Este es un estudio ciego y descriptivo con análisis de imágenes histológicas de biopsia. El historial de tabaquismo asociado con la presencia de antracosis pulmonar, engrosamiento septal y bullas enfisematosas comprendió los criterios de inclusión del estudio. La muestra consistió en biopsias de pulmón, diafragma y esternocleidomastoideo. El estudio se realizó mediante análisis microscópico óptico de láminas histológicas obtenidas de 36 cadáveres con Enfermedad Pulmonar Obstructiva Crónica. El diagnóstico histopatológico fue realizado por un patólogo que desconocía los objetivos del estudio. Resultados: En el diafragma, hubo la presencia de tejido adiposo interpuesto, atrofia muscular, eliminación de las fibras musculares y fibrosis. En el esternocleidomastoideo, también se evidenció la eliminación de las fibras musculares, la atrofia muscular, el tejido adiposo interpuesto, la hipertrofia muscular y el engrosamiento de los tendones. Conclusión: Los cambios encontrados en las biopsias musculares de diafragma y esternocleidomastoideo de los cadáveres con Enfermedad Pulmonar Obstructiva Crónica se evidenciaron como un mecanismo de compensación y/o disfunción del sistema respiratorio debido a alteraciones biomecánicas promovidas por la enfermedad.spa
dc.language.isospapor
dc.publisherUniversidad Ricardo Palma (URP)eng
dc.relation.ispartofRevista de la Facultad de Medicina Humana
dc.rightsopenAccesseng
dc.subjectChronic obstructive pulmonary diseaseeng
dc.subjectStriated muscleeng
dc.subjectAnthracosiseng
dc.subjectTobacco Use Disordereng
dc.subjectAutopsy (source: MeSH NLM)eng
dc.subjectEnfermedad pulmonar obstructiva crónicaeng
dc.subjectMúsculo estriadoeng
dc.subjectAntracosiseng
dc.subjectTabaquismoeng
dc.subjectAutopsia (fuente: DeCS BIREME)eng
dc.titleHALLAZGOS MICROSCÓPICOS DEL TEJIDO PULMONAR Y LOS MÚSCULOS RESPIRATORIOS EN LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA (EPOC)eng
dc.title.alternativeMICROSCOPIC FINDINGS OF LUNG TISSUE AND RESPIRATORY MUSCLES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)eng
dc.typearticleeng
dc.rights.holderCopyright Universidad Ricardo Palma (URP)eng
dc.identifier.doi10.25176/rfmh.v20i1.2447
dc.subject.wosMedicine, General & Internaleng
dc.subject.wosMedicine, Research & Experimentaleng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalCARTAXO DE SOUZA, Tácio Nertan:Universidade Federal de Alagoas, Brazil
hcfmusp.author.externalMARTINS LUCENA, Byron:Municipalidad de Maceió, Brasil
hcfmusp.author.externalSANTOS SANTANA, Fernanda Mayara:Universidade Federal de Alagoas, Brazil
hcfmusp.author.externalZAMBRANO, Lysien Ivania:Departamento de Ciencias Morfológicas, Facultad de Ciencias Médicas, Honduras
hcfmusp.author.externalDE CARVALHO ARAUJO, Ana Rose:Universidade Estadual de Ciências da Saúde de Alagoas, Brazil
hcfmusp.author.externalDE GUSMÃO FREIRE, Ana Lúcia:Universidade Estadual de Ciências da Saúde de Alagoas, Brazil
hcfmusp.description.beginpage55
hcfmusp.description.endpage63
hcfmusp.description.issue1
hcfmusp.description.volume20
hcfmusp.origemsciELO
hcfmusp.origem.idSCIELO:S2308-05312020000100055
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dc.description.indexSciELOeng
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