Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/39721
Title: Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma
Authors: BRONDANI, Vania BalderramaLACOMBE, Amanda Meneses FerreiraMARIANI, Beatriz Marinho de PaulaMONTENEGRO, LucianaSOARES, Ibere CauduroBEZERRA-NETO, Joao EvangelistaTANNO, Fabio YoshiakiSROUGI, VictorCHAMBO, Jose LuisMENDONCA, Berenice BilharinhoALMEIDA, Madson Q.ZERBINI, Maria Claudia NogueiraFRAGOSO, Maria Candida Barisson Villares
Citation: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.3, article ID 1238, 19p, 2021
Abstract: Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of ATRX and ZNRF3 genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of ATRX and ZNRF3 in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of ATRX and ZNRF3 was associated with a decrease in overall survival (OS) (p = 0.045, p = 0.012, respectively). The Cox regression for ATRX protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997; p = 0.049) when compared with <= 1.5; for ZNRF3 expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852; p = 0.015) when compared with <= 2. High ATRX and ZNRF3 protein expressions were associated with optimistic recurrence-free survival (RFS) (p = 0.027 and p = 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for ATRX expression >2.7 (p = 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for ZNRF3 expression >2 (p = 0.013). In conclusion, low protein expression of ATRX and ZNRF3 are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings.
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Instituto do Câncer do Estado de São Paulo - HC/ICESP

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ODS/03 - Saúde e bem-estar


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