https://observatorio.fm.usp.br/handle/OPI/39721
Título: | Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma |
Autor: | BRONDANI, Vania Balderrama; LACOMBE, Amanda Meneses Ferreira; MARIANI, Beatriz Marinho de Paula; MONTENEGRO, Luciana; SOARES, Ibere Cauduro; BEZERRA-NETO, Joao Evangelista; TANNO, Fabio Yoshiaki; SROUGI, Victor; CHAMBO, Jose Luis; MENDONCA, Berenice Bilharinho; ALMEIDA, Madson Q.; ZERBINI, Maria Claudia Nogueira; FRAGOSO, Maria Candida Barisson Villares |
Citación: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.3, article ID 1238, 19p, 2021 |
Resumen: | Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of ATRX and ZNRF3 genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of ATRX and ZNRF3 in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of ATRX and ZNRF3 was associated with a decrease in overall survival (OS) (p = 0.045, p = 0.012, respectively). The Cox regression for ATRX protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997; p = 0.049) when compared with <= 1.5; for ZNRF3 expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852; p = 0.015) when compared with <= 2. High ATRX and ZNRF3 protein expressions were associated with optimistic recurrence-free survival (RFS) (p = 0.027 and p = 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for ATRX expression >2.7 (p = 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for ZNRF3 expression >2 (p = 0.013). In conclusion, low protein expression of ATRX and ZNRF3 are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/42 Artigos e Materiais de Revistas Científicas - ODS/03 |
Fichero | Descripción | Tamaño | Formato | |
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art_BRONDANI_Low_Protein_Expression_of_both_ATRX_and_ZNRF3_2021.PDF | publishedVersion (English) | 7.35 MB | Adobe PDF | Visualizar/Abrir |
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