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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFERMINO, Marise L.-
dc.contributor.authorDIAS, Fabricio C.-
dc.contributor.authorLOPES, Carla D.-
dc.contributor.authorSOUZA, Maria A.-
dc.contributor.authorCRUZ, Angela K.-
dc.contributor.authorLIU, Fu-Tong-
dc.contributor.authorCHAMMAS, Roger-
dc.contributor.authorROQUE-BARREIRA, Maria Cristina-
dc.contributor.authorRABINOVICH, Gabriel A.-
dc.contributor.authorBERNARDES, Emerson S.-
dc.identifier.citationEUROPEAN JOURNAL OF IMMUNOLOGY, v.43, n.7, p.1806-1817, 2013-
dc.description.abstractGalectin-3, an endogenous glycan-binding protein, plays essential roles during microbial infection by modulating innate and adaptive immunity. However, the role of galectin-3 within the CD4(+)CD25(+)Foxp3(+) T regulatory (T-REG) cell compartment has not yet been explored. Here, we found, in a model of Leishmania major infection, that galectin-3 deficiency increases the frequency of peripheral T-REG cells both in draining lymph nodes (LNs) and sites of infection. These observations correlated with an increased severity of the disease, as shown by increased footpad swelling and parasite burden. Galectin-3-deficient (Lgals3(-/-)) T-REG cells displayed higher CD103 expression, showed greater suppressive capacity, and synthesized higher amounts of IL-10 compared with their wild-type (WT) counterpart. Furthermore, both T-REG cells and T effector (T-EFF) cells from Lgals3(-/-) mice showed higher expression of Notch1 and the Notch target gene Hes-1. Interestingly, Notch signaling components were also altered in both T-REG and T-EFF cells from uninfected Lgals3(-/-) mice. Thus, endogenous galectin-3 regulates the frequency and function of CD4(+)CD25(+)Foxp3(+) T-REG cells and alters the course of L. major infection.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional do Desenvolvimento Cientifico e Tecnologico (CNPq)-
dc.description.sponsorshipFundacion Sales and Agencia Nacional de Promocion Cientifica y Tecnologica (Argentina)-
dc.relation.ispartofEuropean Journal of Immunology-
dc.subjectLeishmania major-
dc.subjectT regulatory (Treg) cells-
dc.subjectNotch signaling-
dc.subject.otherinflammatory responses-
dc.subject.otheril-10 production-
dc.subject.otherbinding protein-
dc.subject.otherbalb/c mice-
dc.titleGalectin-3 negatively regulates the frequency and function of CD4(+)CD25(+)Foxp3(+) regulatory T cells and influences the course of Leishmania major infection-
dc.rights.holderCopyright WILEY-BLACKWELL-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Marise L.:Univ Sao Paulo, Dept Biol Celular & Mol, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil-, Fabricio C.:Univ Sao Paulo, Dept Biol Celular & Mol, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil-, Carla D.:Univ Sao Paulo, Dept Biol Celular & Mol, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil-, Maria A.:Univ Sao Paulo, Dept Biol Celular & Mol, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil; Univ Fed Uberlandia, Dept Imunol, Inst Ciencias Biomed, BR-38400 Uberlandia, MG, Brazil-, Angela K.:Univ Sao Paulo, Dept Biol Celular & Mol, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil-, Fu-Tong:Univ Calif Davis, Sch Med, Dept Dermatol, Davis, CA USA-, Maria Cristina:Univ Sao Paulo, Dept Biol Celular & Mol, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil-, Gabriel A.:Consejo Nacl Invest Cient & Tecn, Lab Inmunopatol, IBYME, Buenos Aires, DF, Argentina; Univ Buenos Aires, Lab Glic Estruct & Func, Dept Quim Biol, Fac Ciencias Exactas & Nat, Buenos Aires, DF, Argentina-, Emerson S.:Univ Sao Paulo, Dept Radiol & Oncol, Fac Med, BR-05508 Sao Paulo, Brazil; Ctr Translat Res Oncol CTO, Canc Inst State Sao Paulo ICESP, Sao Paulo, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MDR
Departamento de Radiologia - FM/MDR

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

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