The histology of prostate tissue following prostatic artery embolization for the treatment of benign prostatic hyperplasia

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author CAMARA-LOPES, George FMUSP-HC
MATTEDI, Romulo FMUSP-HC
ANTUNES, Alberto A. FMUSP-HC
CARNEVALE, Francisco C. FMUSP-HC
CERRI, Giovanni G. FMUSP-HC
SROUGI, Miguel FMUSP-HC
ALVES, Venancio A. FMUSP-HC
LEITE, Katia R. M. FMUSP-HC
dc.date.issued 2013
dc.identifier.citation INTERNATIONAL BRAZ J UROL, v.39, n.2, p.222-227, 2013
dc.identifier.issn 1677-5538
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/4018
dc.description.abstract Objective: Prostatic artery embolization (PAE) for the treatment of patients with symptomatic benign prostatic hyperplasia (BPH) is believed to be a safe procedure with a low risk of adverse side effects. Artery embolization is a viable treatment option in patients who are refractory to the classic noninvasive treatments. Knowledge of the histological characteristics of prostate tissue following the procedure is still limited. In this study, we describe the microscopic aspects of the prostate following PAE for BPH. Materials and Methods: Two patients underwent transurethral resections of the prostate (TURP) after PAE. Embolizations were performed under local anesthesia with an initial pelvic angiography to evaluate the iliac vessels and the prostate arteries using a 2.8 French microcatheter. The prostate was embolized with 300-500 mu m Microspheres (Embosphere (R)), using complete blood stasis as the end point. The prostate tissues were analyzed histologically to characterize the effects of the embolization. Results: The embolic material within the prostate tissue was easily identified as homogeneous, bright eosin-red spheroids filling the vessel lumens. Ischemic necrosis surrounded or not by chronic inflammatory reactions containing macrophages were considered as a result of the artery embolization. Also, some aspects related to the healing process were observed being fibrotic nodules surrounded by glands with squamous metaplasia of the epithelial lining the most important. In the remaining sections, due to the precocious surgical intervention, the classic findings of BPH were still present with the glandular and stromal hyperplasia associated with nonspecific chronic prostatitis. Conclusions: This is the first description of prostate histology in BPH patients treated by PAE, a new procedure that is being used increasingly as a therapeutic intervention. The recognition of the changes caused by this new modality of treatment has become a very important differential in a chronic granulomatous reaction of the prostate tissue.
dc.language.iso eng
dc.publisher BRAZILIAN SOC UROL
dc.relation.ispartof International Braz J Urol
dc.rights openAccess
dc.subject Prostatic Hyperplasia; Therapeutics; Arteries; Histology; Embolization, Therapeutic; Prostate
dc.subject.other massive hematuria; prevalence; hemorrhage; men
dc.title The histology of prostate tissue following prostatic artery embolization for the treatment of benign prostatic hyperplasia
dc.type article
dc.rights.holder Copyright BRAZILIAN SOC UROL
dc.description.group LIM/55
dc.description.group LIM/14
dc.description.group LIM/44
dc.identifier.doi 10.1590/S1677-5538.IBJU.2013.02.11
dc.identifier.pmid 23683668
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author CAMARA-LOPES, George:HC:ICHC
hcfmusp.author MATTEDI, Romulo:HC:ICESP
hcfmusp.author ANTUNES, Alberto A.:HC:LIM/55
hcfmusp.author CARNEVALE, Francisco C.:HC:INRAD
hcfmusp.author CERRI, Giovanni G.:FM:MDR
hcfmusp.author SROUGI, Miguel:FM:MCG
hcfmusp.author ALVES, Venancio A.:FM:MPT
hcfmusp.author LEITE, Katia R. M.:HC:LIM/55
hcfmusp.origem.id 2-s2.0-84891702039
hcfmusp.origem.id WOS:000323497500011
hcfmusp.origem.id SCIELO:S1677-55382013000200222
hcfmusp.publisher.city RIO DE JANEIRO
hcfmusp.publisher.country BRAZIL
hcfmusp.relation.reference · APPLETON DS, 1988, BRIT J UROL, V61, P45, DOI 10.1111/j.1464-410X.1988.tb09160.x
· AUA Practice Guidelines Committee, 2003, J UROLOGY, V170, P530
· Aungst M, 2004, OBSTET GYNECOL, V104, P1161, DOI 10.1097/01.AOG.0000128107.58898.e1
· Barbieri A, 2002, UROL INT, V69, P318, DOI 10.1159/000066115
· Barry MJ, 2005, TXB BENIGN PROSTATIC, P141
· Carnevale FC, 2011, CARDIOVASC INTER RAD, V34, P1330, DOI 10.1007/s00270-011-0136-8
· Carnevale FC, 2010, CARDIOVASC INTER RAD, V33, P355, DOI 10.1007/s00270-009-9727-z
· Cioanta I, 2000, Tech Urol, V6, P294
· Emberton M, 2003, UROLOGY, V61, P267, DOI 10.1016/S0090-4295(02)02371-3
· Evans AJ, 2011, ADV ANAT PATHOL, V18, P281, DOI 10.1097/PAP.0b013e318220f5b1
· GUESS HA, 1990, PROSTATE, V17, P241, DOI 10.1002/pros.2990170308
· HUMPHREY PA, 1993, AM J CLIN PATHOL, V99, P746
· Issa MM, 2006, AM J MANAG CARE, V12, pS83
· Kuzel D, 2011, FERTIL STERIL, V95, P2143, DOI 10.1016/j.fertnstert.2010.12.014
· Merrimen JL, 2009, J UROLOGY, V182, P485, DOI 10.1016/j.juro.2009.04.016
· Michel F, 2002, J UROLOGY, V168, P2550, DOI 10.1097/01.ju.0000036371.49460.7d
· MITCHELL ME, 1976, J UROLOGY, V115, P692
· Rastinehad AR, 2008, UROLOGY, V71, P181, DOI 10.1016/j.urology.2007.09.012
· Roehrborn CG, 1998, UROLOGY, V51, P19, DOI 10.1016/S0090-4295(97)00571-2
· Roehrborn CG, 1998, UROLOGY, V51, P415, DOI 10.1016/S0090-4295(97)00682-1
· Sun F, 2008, RADIOLOGY, V246, P783, DOI 10.1148/radiol.2463070647
· Takeda A, 2008, J MINIM INVAS GYN, V15, P212, DOI 10.1016/j.jmig.2007.09.006
· Wheelahan J, 2000, BJU INT, V86, P805, DOI 10.1046/j.1464-410x.2000.00920.x
· Ziada A, 1999, UROLOGY, V53, P1, DOI 10.1016/S0090-4295(98)00532-9
dc.description.index MEDLINE
dc.identifier.eissn 1677-6119
hcfmusp.citation.scopus 28


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace



Browse

My Account

Statistics