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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBENADIBA, Marcel-
dc.contributor.authorLUURTSEMA, Gert-
dc.contributor.authorTUMAS, Vitor-
dc.contributor.authorBUCHPIGEL, Carlos Alberto-
dc.contributor.authorBUSATTO, Geraldo F.-
dc.identifier.citationJOURNAL OF PARKINSONS DISEASE, v.3, n.3, p.301-323, 2013-
dc.description.abstractThe pathophysiology of Parkinson's disease (PD) has not yet been completely elucidated. However, during the past few years, significant progress has been made in understanding the intra- and extracellular mechanisms by which proteins such as alpha-synuclein and neuroinflammatory molecules may display impaired function and/or expression in PD. Recent developments in imaging techniques based on positron emission tomography (PET) and single photon emission computed tomography (SPECT) now allow the non-invasive tracking of such molecular targets of known relevance to PD in vivo. This article summarizes recent PET and SPECT studies of new radiopharmaceuticals and discusses their potential role and perspectives for use in the fields of new drug development and early diagnosis for PD, as well to aid in differential diagnosis and monitoring of the progression of PD.-
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Brazilian agency-
dc.publisherIOS PRESS-
dc.relation.ispartofJournal of Parkinsons Disease-
dc.subjectsingle-photon emission-computed tomography-
dc.subjectParkinson disease-
dc.subjectradioactive tracers-
dc.subjectlipid metabolism-
dc.subject.otherp-glycoprotein function-
dc.subject.otherin-vivo evaluation-
dc.subject.othercancer resistance protein-
dc.subject.otheracid amide hydrolase-
dc.subject.otherinterleukin-1 receptor antagonist-
dc.subject.othercannabinoid cb1 receptors-
dc.titleNew Perspectives in Nuclear Neurology for the Evaluation of Parkinson's Disease-
dc.rights.holderCopyright IOS PRESS-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Gert:Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9713 GZ Groningen, Netherlands-, Vitor:Univ Sao Paulo, NAPNA, Sao Paulo, Brazil; Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, Ribeirao Preto, SP, Brazil-
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