Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/40526
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEBKUCHEN, Adriana
dc.contributor.authorFREITAS, Lunara S.
dc.contributor.authorCARDOZO, Karina H. M.
dc.contributor.authorDRAGER, Luciano F.
dc.date.accessioned2021-06-17T13:50:27Z-
dc.date.available2021-06-17T13:50:27Z-
dc.date.issued2021
dc.identifier.citationTRENDS IN CARDIOVASCULAR MEDICINE, v.31, n.4, p.242-249, 2021
dc.identifier.issn1050-1738
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40526-
dc.description.abstractSeveral challenges have been noted in the pursuit of a comprehensive knowledge base about the impact of OSA including: 1) the precise mechanisms by which OSA causes metabolic and cardiovascular consequences are not clear, which limits our current ability to address potential targets in OSA; 2) several patients with OSA, even with severe forms, present with no or mild daytime symptoms. Beyond the obvious challenges for obtaining good adherence for conventional OSA treatments, there is evidence that symptomatic vs. asymptomatic patients with OSA do not necessarily have the same metabolic and cardiovascular outcomes; and 3) the cardiovascular response to OSA treatment may vary even in those patients with good adherence. In this scenario, there is an obvious need to develop biomarkers in the OSA research area. This review focuses on describing the advances that have occurred so far in exploring potential OSA biomarkers with clear emphasis for the cardiovascular risk. Particular attention will be devoted to discuss molecular biomarkers including the potential role of microRNAs, proteomics and metabolomics. We also discuss the major challenges and perspectives in this growing research field. Obstructive sleep apnea (OSA) is a common clinical condition associated with increased cardiovascular morbidity and mortality. Recent evidence from clinical studies and animal models suggest that OSA can promote cardiovascular disease by inducing autonomic, hemodynamic, inflammatory and metabolic dysregulation. However, most of the evidence addressing hard endpoints in humans is derived from observational studies. Several challenges have been noted in the pursuit of a comprehensive knowledge base about the impact of OSA including: 1) the precise mechanisms by which OSA causes metabolic and cardiovascular consequences are not clear, which limits our current ability to address potential targets in OSA; 2) several patients with OSA, even with severe forms, present with no or mild daytime symptoms. Beyond the obvious challenges for obtaining good adherence for conventional OSA treatments, there is evidence that symptomatic vs. asymptomatic patients with OSA do not necessarily have the same metabolic and cardiovascular outcomes; and 3) the cardiovascular response to OSA treatment may vary even in those patients with good adherence. In this scenario, there is an obvious need to develop biomarkers in the OSA research area. This review focuses on describing the advances that have occurred so far in exploring potential OSA biomarkers with clear emphasis for the cardiovascular risk. Particular attention will be devoted to discuss molecular biomarkers including the potential role of microRNAs, proteomics and metabolomics. We also discuss the major challenges and perspectives in this growing research field.eng
dc.language.isoeng
dc.publisherELSEVIER SCIENCE LONDONeng
dc.relation.ispartofTrends in Cardiovascular Medicine
dc.rightsrestrictedAccesseng
dc.subjectBiomarkerseng
dc.subjectCardiovascular diseaseeng
dc.subjectPrognosiseng
dc.subjectSleep apneaeng
dc.titleAdvances and challenges in pursuing biomarkers for obstructive sleep apnea: Implications for the cardiovascular risk ?eng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER SCIENCE LONDONeng
dc.identifier.doi10.1016/j.tcm.2020.04.003
dc.identifier.pmid32413393
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalLEBKUCHEN, Adriana:Fleury Grp, Sao Paulo, Brazil
hcfmusp.author.externalFREITAS, Lunara S.:Univ Sao Paulo, Med Sch, Heart Inst InCor, Hypertens Unit, Ave Dr Eneas de Carvalho Aguiar 44, BR-05403900 Sao Paulo, Brazil
hcfmusp.author.externalCARDOZO, Karina H. M.:Fleury Grp, Sao Paulo, Brazil
hcfmusp.description.beginpage242
hcfmusp.description.endpage249
hcfmusp.description.issue4
hcfmusp.description.volume31
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000635769900008
hcfmusp.origem.id2-s2.0-85085945128
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceAbbassi-Ghadi N, 2013, EUR J CANCER, V49, P3625, DOI 10.1016/j.ejca.2013.07.004eng
hcfmusp.relation.referenceAmann A, 2005, BREATH ANALYSIS: FOR CLINICAL DIAGNOSIS AND ATHERAPEUTIC MONITORING, P305, DOI 10.1142/9789812701954_0020eng
hcfmusp.relation.referenceAnderson NL, 2000, CURR OPIN BIOTECH, V11, P408, DOI 10.1016/S0958-1669(00)00118-Xeng
hcfmusp.relation.reference[Anonymous], 2006, AM J RESP CRIT CARE, V173, P811, DOI 10.1164/rrcm.2061014eng
hcfmusp.relation.referenceArchontogeorgis K, 2014, PULM MED, V2014, DOI 10.1155/2014/930535eng
hcfmusp.relation.referenceAtkinson AJ, 2001, CLIN PHARMACOL THER, V69, P89, DOI 10.1067/mcp.2000.113989eng
hcfmusp.relation.referenceAyas NT, 2019, LUNG, V197, P459, DOI 10.1007/s00408-019-00237-0eng
hcfmusp.relation.referenceAzarbarzin A, 2019, EUR HEART J, V40, P1149, DOI 10.1093/eurheartj/ehy624eng
hcfmusp.relation.referenceBagga S, 2005, CELL, V122, P553, DOI 10.1016/j.cell.2005.07.031eng
hcfmusp.relation.referenceBarbe F, 2001, ANN INTERN MED, V134, P1015, DOI 10.7326/0003-4819-134-11-200106050-00007eng
hcfmusp.relation.referenceBaron KG, 2018, SLEEP MED REV, V40, P151, DOI 10.1016/j.smrv.2017.12.002eng
hcfmusp.relation.referenceBayrakli I, 2016, BIOMED CHROMATOGR, V30, P1890, DOI 10.1002/bmc.3757eng
hcfmusp.relation.referenceBenjafield AV, 2019, LANCET RESP MED, V7, P687, DOI 10.1016/S2213-2600(19)30198-5eng
hcfmusp.relation.referenceBratel T, 1999, RESP MED, V93, P1, DOI 10.1016/S0954-6111(99)90068-9eng
hcfmusp.relation.referenceCanto GD, 2015, SLEEP MED REV, V23, P28, DOI 10.1016/j.smrv.2014.11.004eng
hcfmusp.relation.referenceCintra F, 2011, CHEST, V139, P246, DOI 10.1378/chest.10-0667eng
hcfmusp.relation.referenceCosta LE, 2015, HEART, V101, P1288, DOI 10.1136/heartjnl-2014-307276eng
hcfmusp.relation.referenceCraig SE, 2012, THORAX, V67, P1090, DOI 10.1136/thoraxjnl-2012-202178eng
hcfmusp.relation.referenceCuspidi C, 2017, J CLIN HYPERTENS, V19, P713, DOI 10.1111/jch.13023eng
hcfmusp.relation.referenceFreitas IGD, 2015, SLEEP BREATH, V19, P755, DOI 10.1007/s11325-015-1143-9eng
hcfmusp.relation.referenceDeng T, 2016, ANNU REV PATHOL-MECH, V11, P421, DOI 10.1146/annurev-pathol-012615-044359eng
hcfmusp.relation.referenceDrager LF, 2017, CIRCULATION, V136, P1840, DOI 10.1161/CIRCULATIONAHA.117.029400eng
hcfmusp.relation.referenceDrager LF, 2017, SLEEP SCI, V10, P55, DOI 10.5935/1984-0063.20170009eng
hcfmusp.relation.referenceDrager LF, 2015, AM J PHYSIOL-HEART C, V309, pH1101, DOI 10.1152/ajpheart.00094.2015eng
hcfmusp.relation.referenceDrager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045eng
hcfmusp.relation.referenceFatureto-Borges F, 2018, HYPERTENSION, V72, P399, DOI 10.1161/HYPERTENSIONAHA.118.10825eng
hcfmusp.relation.referenceFeliciano A, 2017, DATA BRIEF, V11, P103, DOI 10.1016/j.dib.2017.01.005eng
hcfmusp.relation.referenceFerrarini A, 2013, ELECTROPHORESIS, V34, P2873, DOI 10.1002/elps.201300081eng
hcfmusp.relation.referenceFOLLENIUS M, 1991, SLEEP, V14, P211eng
hcfmusp.relation.referenceFreitas LS, 2020, SLEEP BREATH, V24, P1463, DOI 10.1007/s11325-019-02003-1eng
hcfmusp.relation.referenceGenta-Pereira DC, 2018, HYPERTENSION, V72, P979, DOI 10.1161/HYPERTENSIONAHA.118.11525eng
hcfmusp.relation.referenceGeovanini GR, 2016, HEART, V102, P1193, DOI 10.1136/heartjnl-2015-309009eng
hcfmusp.relation.referenceGiampa SQC, 2018, J HUM HYPERTENS, V32, P518, DOI 10.1038/s41371-018-0072-zeng
hcfmusp.relation.referenceGozal D, 2009, AM J RESP CRIT CARE, V180, P1253, DOI 10.1164/rccm.200905-0765OCeng
hcfmusp.relation.referenceGriffin JL, 2011, NAT REV CARDIOL, V8, P630, DOI 10.1038/nrcardio.2011.138eng
hcfmusp.relation.referenceGupta SK, 2010, CIRC-CARDIOVASC GENE, V3, P484, DOI 10.1161/CIRCGENETICS.110.958363eng
hcfmusp.relation.referenceHaight James S J, 2003, Sleep Breath, V7, P53, DOI 10.1007/s11325-003-0053-4eng
hcfmusp.relation.referenceInsenser M, 2013, EXPERT REV PROTEOMIC, V10, P435, DOI 10.1586/14789450.2013.837665eng
hcfmusp.relation.referenceJenner R, 2017, J CLIN HYPERTENS, V19, P910, DOI 10.1111/jch.13008eng
hcfmusp.relation.referenceKhalyfa A, 2020, EUR RESPIR J, V55, DOI 10.1183/13993003.01072-2019eng
hcfmusp.relation.referenceKhalyfa A, 2020, SLEEP, V43, DOI 10.1093/sleep/zsz217eng
hcfmusp.relation.referenceKhalyfa A, 2016, SLEEP, V39, P2077, DOI 10.5665/sleep.6302eng
hcfmusp.relation.referenceKhalyfa A, 2016, AM J RESP CRIT CARE, V194, P1116, DOI 10.1164/rccm.201602-0323OCeng
hcfmusp.relation.referenceKheirandish-Gozal L, 2017, CHEST, V151, P500, DOI 10.1016/j.chest.2016.09.026eng
hcfmusp.relation.referenceKohli M, 2019, SLEEP MED, V64, P92, DOI 10.1016/j.sleep.2019.07.002eng
hcfmusp.relation.referenceKokturk O, 2006, RESP MED, V100, P536, DOI 10.1016/j.rmed.2005.05.025eng
hcfmusp.relation.referenceKonvalinka A, 2012, CLIN CHEM, V58, P353, DOI 10.1373/clinchem.2011.165969eng
hcfmusp.relation.referenceKuniyoshi FHS, 2011, CHEST, V140, P1192, DOI 10.1378/chest.10-2625eng
hcfmusp.relation.referenceLal C, 2019, SLEEP BREATH, V23, P251, DOI 10.1007/s11325-018-1693-8eng
hcfmusp.relation.referenceLavie L, 2001, CHEST, V120, P900, DOI 10.1378/chest.120.3.900eng
hcfmusp.relation.referenceLebkuchen A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29727-6eng
hcfmusp.relation.referenceLee CH, 2016, CIRCULATION, V133, P2008, DOI 10.1161/CIRCULATIONAHA.115.019392eng
hcfmusp.relation.referenceLEE RC, 1993, CELL, V75, P843, DOI 10.1016/0092-8674(93)90529-Yeng
hcfmusp.relation.referenceLi K, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000009813eng
hcfmusp.relation.referenceLi RX, 2002, J MOL CATAL A-CHEM, V178, P181, DOI 10.1016/S1381-1169(01)00294-1eng
hcfmusp.relation.referenceLim LP, 2005, NATURE, V433, P769, DOI 10.1038/nature03315eng
hcfmusp.relation.referenceMaeder MT, 2016, CLIN CHIM ACTA, V460, P152, DOI 10.1016/j.cca.2016.06.046eng
hcfmusp.relation.referenceMarin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7eng
hcfmusp.relation.referenceMarti-Soler H, 2016, LANCET RESP MED, V4, P742, DOI 10.1016/S2213-2600(16)30075-3eng
hcfmusp.relation.referenceMartinez-Garcia MA, 2013, JAMA-J AM MED ASSOC, V310, P2407, DOI 10.1001/jama.2013.281250eng
hcfmusp.relation.referenceMazzotti DR, 2019, AM J RESP CRIT CARE, V200, P493, DOI 10.1164/rccm.201808-1509OCeng
hcfmusp.relation.referenceMitchell PS, 2008, P NATL ACAD SCI USA, V105, P10513, DOI 10.1073/pnas.0804549105eng
hcfmusp.relation.referenceMoreno-Pino F, 2019, J CLIN SLEEP MED, V15, P1645, DOI 10.5664/jcsm.8032eng
hcfmusp.relation.referenceMurri M, 2014, CLIN CHIM ACTA, V429, P181, DOI 10.1016/j.cca.2013.12.018eng
hcfmusp.relation.referenceNordstrom A, 2010, J NEUROIMMUNE PHARM, V5, P4, DOI 10.1007/s11481-009-9156-4eng
hcfmusp.relation.referenceO'Neil SE, 2011, J PROTEOMICS, V75, P192, DOI 10.1016/j.jprot.2011.10.008eng
hcfmusp.relation.referenceOZAKI N, 1986, NEUROPSYCHOBIOLOGY, V16, P88, DOI 10.1159/000118304eng
hcfmusp.relation.referencePatti GJ, 2012, NAT REV MOL CELL BIO, V13, P263, DOI 10.1038/nrm3314eng
hcfmusp.relation.referencePeres BU, 2019, SLEEP MED REV, V44, P48, DOI 10.1016/j.smrv.2018.12.004eng
hcfmusp.relation.referencePerry JC, 2007, RESP PHYSIOL NEUROBI, V156, P250, DOI 10.1016/j.resp.2006.10.004eng
hcfmusp.relation.referenceReinhart BJ, 2000, NATURE, V403, P901, DOI 10.1038/35002607eng
hcfmusp.relation.referenceRhee EP, 2012, CLIN CHEM, V58, P139, DOI 10.1373/clinchem.2011.169573eng
hcfmusp.relation.referenceSanchez-de-la-Torre M, 2015, J AM COLL CARDIOL, V66, P1023, DOI 10.1016/j.jacc.2015.06.1315eng
hcfmusp.relation.referenceSantamaria-Martos F, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49940-1eng
hcfmusp.relation.referenceSeetho IW, 2014, CHRON RESP DIS, V11, P257, DOI 10.1177/1479972314552806eng
hcfmusp.relation.referenceShukla HD, 2012, PROTEOMICS, V12, P3085, DOI 10.1002/pmic.201100519eng
hcfmusp.relation.referenceSnowden S, 2012, BIOANALYSIS, V4, P2265, DOI [10.4155/BIO.12.218, 10.4155/bio.12.218]eng
hcfmusp.relation.referenceStenlof K, 1996, AM J PHYSIOL-ENDOC M, V271, pE1036eng
hcfmusp.relation.referenceSutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82eng
hcfmusp.relation.referenceSvatikova A, 2004, EUR HEART J, V25, P1325, DOI 10.1016/j.ehj.2004.05.018eng
hcfmusp.relation.referenceUchoa CHG, 2017, CHEST, V152, P1230, DOI 10.1016/j.chest.2017.08.003eng
hcfmusp.relation.referenceVasan RS, 2006, CIRCULATION, V113, P2335, DOI 10.1161/CIRCULATIONAHA.104.482570eng
hcfmusp.relation.referenceVerma Mukesh, 2011, Cancers (Basel), V3, P3773, DOI 10.3390/cancers3043773eng
hcfmusp.relation.referenceWaterman CL, 2010, BBA-MOL CELL BIOL L, V1801, P230, DOI 10.1016/j.bbalip.2009.11.004eng
hcfmusp.relation.referenceXu HJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep30958eng
hcfmusp.relation.referenceYaggi HK, 2005, NEW ENGL J MED, V353, P2034, DOI 10.1056/NEJMoa043104eng
hcfmusp.relation.referenceZhang DM, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006429eng
hcfmusp.relation.referenceZhang HN, 2018, METABOLISM, V85, P97, DOI 10.1016/j.metabol.2018.02.012eng
hcfmusp.relation.referenceZhao YY, 2013, CLIN CHIM ACTA, V422, P59, DOI 10.1016/j.cca.2013.03.033eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1873-2615
hcfmusp.citation.scopus8-
hcfmusp.scopus.lastupdate2022-04-15-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/63
LIM/63 - Laboratório de Investigação Médica em Sono

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_LEBKUCHEN_Advances_and_challenges_in_pursuing_biomarkers_for_obstructive_2021.PDF
  Restricted Access
publishedVersion (English)1.44 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.