Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/40532
Title: Management of functioning pediatric adrenal tumors
Authors: LOPES, Roberto IglesiasSUARTZ, Caio ViniciusPEDRENHO NETO, RubensBERJEAUT, Ricardo HaidarMENDONCA, BereniceALMEIDA, Madson Q.FRAGOSO, Maria Candida VillaresDENES, Francisco Tibor
Citation: JOURNAL OF PEDIATRIC SURGERY, v.56, n.4, p.768-771, 2021
Abstract: Aim: The aim of this study is to present our experience in the management of hormonally active adrenal tumors in children.& nbsp; Material and methods: We did a retrospective chart review of all children with hormonally active adrenal tumors evaluated at the endocrinology clinic and operated at our institution between 1983 and 2019.& nbsp; Results: There were 75 patients included in the study, 58 with adrenocortical tumors (ACTs) and 17 with pheochromocytomas (PCCs). Within the group of patients with ACTs, there were 41 females and 17 males. The mean age was 58.3 (SD: 87.9; range: 9 & ndash;211) months. The clinical manifestation of the tumor's hormonal activity was virilization in 37 cases, Cushing syndrome in 5, and mixed in 16. A positive family history was present in 11 patients (18.9%). The mean tumor size was 48.2 (SD: 22.4; range: 7 & ndash;120) mm. The pathological diagnosis was adenoma in 42 cases, carcinoma in 15 cases, and macronodular hyperplasia in 1. Median follow-up was 192 (range: 50 & ndash;290) months. Tumor recurrence occurred in 6 patients (10.3%), and there were three disease-related deaths (5%). Within the group of patients with PCCs, there were 11 males and 6 females. The mean age was 146.7 (SD: 71.2; range: 60 & ndash;216) months. A positive family history was present in 7 patients (41.2%). The mean tumor size was 36.6 (SD: 16.7; range: 7 & ndash;120) mm. The pheochromocytoma was classified as benign in 15 cases and as malignant in 2. During a median follow-up of 180 (range: 127 & ndash;300) months, recurrence was observed in 6 cases (35.3%) and disease-related death in 1 case (5.9%).& nbsp; Conclusions: Proper diagnosis and management at our referral center were associated with a high cure rate, even in cases of malignant tumors. Familial surveillance is highly recommended.& nbsp; Level of evidence: Level IV.& nbsp; (c) 2020 Elsevier Inc. All rights reserved.
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/42
LIM/42 - Laboratório de Hormônios e Genética Molecular

Artigos e Materiais de Revistas Científicas - LIM/55
LIM/55 - Laboratório de Urologia

Artigos e Materiais de Revistas Científicas - ODS/03


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