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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUZA, Silvana P.
dc.contributor.authorSANTOS, Ronaldo B.
dc.contributor.authorSANTOS, Itamar S.
dc.contributor.authorPARISE, Barbara K.
dc.contributor.authorGIATTI, Soraya
dc.contributor.authorAIELO, Aline N.
dc.contributor.authorCUNHA, Lorenna F.
dc.contributor.authorSILVA, Wagner A.
dc.contributor.authorBORTOLOTTO, Luiz A.
dc.contributor.authorLORENZI-FILHO, Geraldo
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorBENSENOR, Isabela M.
dc.contributor.authorDRAGER, Luciano F.
dc.date.accessioned2021-06-17T13:50:29Z-
dc.date.available2021-06-17T13:50:29Z-
dc.date.issued2021
dc.identifier.citationARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v.41, n.4, p.1549-1557, 2021
dc.identifier.issn1079-5642
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40539-
dc.description.abstractObjective: To elucidate the independent associations of obstructive sleep apnea (OSA) and sleep duration (SD) as well as the potential inflammatory and metabolic mediators on carotid intima-media thickness (CIMT) in a large cohort of adults. Approach and Results: Consecutive participants from the ELSA-Brasil performed a clinical evaluation, sleep study, 1-week actigraphy for defining SD and CIMT using standard techniques. Gamma regression models were used to explore the association between OSA and SD with CIMT. Mediation analysis was performed using the mediation R package. A total of 2009 participants were included in the main analysis. As compared with no OSA (apnea-hypopnea index [AHI] <5 events/hour; n=613), patients with mild (AHI, 5-14.9; n=741), moderate (AHI, 15-29.9; n=389), and severe OSA (AHI >= 30 events/hour; n=266) presented a progressive CIMT increase (0.690 [0.610-0.790], 0.760 [0.650-0.890], 0.810 [0.700-0.940], and 0.820 [0.720-0.958] mm; P<0.001). In contrast, CIMTs were similar for those with SD <6 hours (0.760 [0.650-0.888]), 6 to 8 hours (0.750 [0.640-0.880]) and >8 hours (0.740 [0.670-0.900]). All forms of OSA were independently associated with CIMT (mild: beta: 0.019, SE 0.008; P=0.022; moderate: beta: 0.025, SE 0.011; P=0.022; severe OSA: beta: 0.040, SE 0.013; P=0.002). Moreover, the association of AHI with CIMT was mediated by increased C-reactive protein and triglycerides (P<0.01). SD did not interact with OSA in the association with CIMT. Conclusions: OSA is independently associated with increased CIMT in a dose-response relationship. This association is partially mediated by inflammation and dyslipidemia. In contrast, SD is not associated nor interacted with OSA to increase CIMT.eng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2019/23496-8]
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofArteriosclerosis Thrombosis and Vascular Biology
dc.rightsrestrictedAccesseng
dc.subjectactigraphyeng
dc.subjectadulteng
dc.subjectatherosclerosiseng
dc.subjectinflammationeng
dc.subjectintima-media thicknesseng
dc.subjectsleep apneaeng
dc.subjectsleep durationeng
dc.subject.othertriglyceride-rich lipoproteinseng
dc.subject.otherintermittent hypoxiaeng
dc.subject.othernonfasting triglycerideseng
dc.subject.othercardiovascular-diseaseeng
dc.subject.othercardiometabolic riskeng
dc.subject.otheratherosclerosiseng
dc.subject.otherdisturbanceseng
dc.subject.otherpopulationeng
dc.subject.otherinsightseng
dc.subject.othereventseng
dc.titleObstructive Sleep Apnea, Sleep Duration, and Associated Mediators With Carotid Intima-Media Thickness The ELSA-Brasil Studyeng
dc.typearticleeng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.identifier.doi10.1161/ATVBAHA.120.315644
dc.identifier.pmid33567870
dc.subject.wosHematologyeng
dc.subject.wosPeripheral Vascular Diseaseeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.description.beginpage1549
hcfmusp.description.endpage1557
hcfmusp.description.issue4
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000639317700032
hcfmusp.origem.id2-s2.0-85103607352
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAielo AN, 2019, SLEEP SCI, V12, P65, DOI 10.5935/1984-0063.20190072eng
hcfmusp.relation.referenceAquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294eng
hcfmusp.relation.referenceAzarbarzin A, 2019, EUR HEART J, V40, P1149, DOI 10.1093/eurheartj/ehy624eng
hcfmusp.relation.referenceAziz M, 2017, J ATHEROSCLER THROMB, V24, P208, DOI 10.5551/jat.36194eng
hcfmusp.relation.referenceBauer M, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13705eng
hcfmusp.relation.referenceBensenor IM, 2013, REV SAUDE PUBL, V47, P37, DOI 10.1590/S0034-8910.2013047003780eng
hcfmusp.relation.referenceBerry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172eng
hcfmusp.relation.referenceCappuccio FP, 2011, EUR HEART J, V32, P1484, DOI 10.1093/eurheartj/ehr007eng
hcfmusp.relation.referenceCespedes EM, 2016, AM J EPIDEMIOL, V183, P561, DOI 10.1093/aje/kwv251eng
hcfmusp.relation.referenceChen XL, 2015, SLEEP, V38, P877, DOI 10.5665/sleep.4732eng
hcfmusp.relation.referenceChowdhuri S, 2016, AM J RESP CRIT CARE, V193, pE37, DOI 10.1164/rccm.201602-0361STeng
hcfmusp.relation.referenceDrager LF, 2007, AM J RESP CRIT CARE, V176, P706, DOI 10.1164/rccm.200703-500OCeng
hcfmusp.relation.referenceDrager LF, 2020, SLEEP SCI, V13, P94, DOI 10.5935/1984-0063.20200028eng
hcfmusp.relation.referenceDrager LF, 2019, CHEST, V155, P1190, DOI 10.1016/j.chest.2018.12.003eng
hcfmusp.relation.referenceDrager LF, 2018, J LIPID RES, V59, P1027, DOI 10.1194/jlr.M083436eng
hcfmusp.relation.referenceDrager LF, 2015, AM J PHYSIOL-HEART C, V309, pH1101, DOI 10.1152/ajpheart.00094.2015eng
hcfmusp.relation.referenceDrager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045eng
hcfmusp.relation.referenceDrager LF, 2013, AM J RESP CRIT CARE, V188, P240, DOI 10.1164/rccm.201209-1688OCeng
hcfmusp.relation.referenceDrager LF, 2012, EUR HEART J, V33, P783, DOI 10.1093/eurheartj/ehr097eng
hcfmusp.relation.referenceDrager LF, 2011, CHEST, V140, P534, DOI 10.1378/chest.10-2223eng
hcfmusp.relation.referenceDrager LF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012065eng
hcfmusp.relation.referenceFreiberg JJ, 2008, JAMA-J AM MED ASSOC, V300, P2142, DOI 10.1001/jama.2008.621eng
hcfmusp.relation.referenceHirotsu C, 2018, EUR RESPIR J, V52, DOI 10.1183/13993003.01150-2018eng
hcfmusp.relation.referenceHirshkowitz M, 2015, SLEEP HEALTH, V1, P233, DOI 10.1016/j.sleh.2015.10.004eng
hcfmusp.relation.referenceKing CR, 2008, JAMA-J AM MED ASSOC, V300, P2859, DOI 10.1001/jama.2008.867eng
hcfmusp.relation.referenceKozakova M, 2014, J CLIN ENDOCR METAB, V99, pE2362, DOI 10.1210/jc.2014-2028eng
hcfmusp.relation.referenceLauderdale DS, 2008, EPIDEMIOLOGY, V19, P838, DOI 10.1097/EDE.0b013e318187a7b0eng
hcfmusp.relation.referenceLi RC, 2011, AM J RESP CRIT CARE, V184, P124, DOI 10.1164/rccm.201012-2039OCeng
hcfmusp.relation.referenceLorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875eng
hcfmusp.relation.referenceMcCullagh P., 1989, GEN LINEAR MODELS, V37eng
hcfmusp.relation.referenceMill JG, 2013, REV SAUDE PUBL, V47, P54, DOI 10.1590/S0034-8910.2013047003851eng
hcfmusp.relation.referenceNordestgaard BG, 2007, JAMA-J AM MED ASSOC, V298, P299, DOI 10.1001/jama.298.3.299eng
hcfmusp.relation.referenceNordestgaard BG, 2016, CIRC RES, V118, P547, DOI 10.1161/CIRCRESAHA.115.306249eng
hcfmusp.relation.referenceRyan S, 2005, CIRCULATION, V112, P2660, DOI 10.1161/CIRCULATIONAHA.105.556746eng
hcfmusp.relation.referenceSantos IS, 2015, ARTERIOSCL THROM VAS, V35, P2054, DOI 10.1161/ATVBAHA.115.305765eng
hcfmusp.relation.referenceSantos IS, 2014, ATHEROSCLEROSIS, V237, P227, DOI 10.1016/j.atherosclerosis.2014.09.004eng
hcfmusp.relation.referenceSimon A, 2010, ARTERIOSCL THROM VAS, V30, P182, DOI 10.1161/ATVBAHA.109.196980eng
hcfmusp.relation.referenceSong D, 2012, BBA-MOL BASIS DIS, V1822, P1650, DOI 10.1016/j.bbadis.2012.07.010eng
hcfmusp.relation.referenceSuzuki S, 2018, J ATHEROSCLER THROMB, V25, P186, DOI 10.5551/jat.40527eng
hcfmusp.relation.referenceTingley D, 2014, J STAT SOFTW, V59eng
hcfmusp.relation.referenceVallat R, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000726eng
hcfmusp.relation.referenceVarbo A, 2013, J AM COLL CARDIOL, V61, P427, DOI 10.1016/j.jacc.2012.08.1026eng
hcfmusp.relation.referenceWang YH, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.5246eng
hcfmusp.relation.referenceWattanakit K, 2008, ATHEROSCLEROSIS, V197, P125, DOI 10.1016/j.atherosclerosis.2007.02.029eng
hcfmusp.relation.referenceWickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3_1eng
hcfmusp.relation.referenceWilleit P, 2020, CIRCULATION, V142, P621, DOI 10.1161/CIRCULATIONAHA.120.046361eng
hcfmusp.relation.referenceZhao YY, 2019, STROKE, V50, P3340, DOI 10.1161/STROKEAHA.118.022184eng
hcfmusp.relation.referenceZhou M, 2017, ANGIOLOGY, V68, P575, DOI 10.1177/0003319716665985eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1524-4636
hcfmusp.citation.scopus14-
hcfmusp.scopus.lastupdate2024-02-23-
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