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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFUKUZAKI, Silvia
dc.contributor.authorRIGHETTI, Renato Fraga
dc.contributor.authorSANTOS, Tabata Maruyama dos
dc.contributor.authorCAMARGO, Leandro do Nascimento
dc.contributor.authorARISTOTELES, Luciana R. C. R. B.
dc.contributor.authorSOUZA, Flavia C. R.
dc.contributor.authorGARRIDO, Aurelio C.
dc.contributor.authorSARAIVA-ROMANHOLO, Beatriz Mangueira
dc.contributor.authorLEICK, Edna Aparecida
dc.contributor.authorPRADO, Carla Maximo
dc.contributor.authorMARTINS, Milton de Arruda
dc.contributor.authorTIBERIO, Iolanda de Fatima Lopes Calvo
dc.date.accessioned2021-06-17T13:50:30Z-
dc.date.available2021-06-17T13:50:30Z-
dc.date.issued2021
dc.identifier.citationAMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v.320, n.3, p.C341-C354, 2021
dc.identifier.issn0363-6143
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40551-
dc.description.abstractChronic obstructive pulmonary disease (COPD) is an important health care issue, and IL-17 can modulate inflammatory responses. We evaluated preventive and therapeutic effect of anti-interleukin (IL)-17 in a model of lung injury induced by elastase, using 32 male C57Bl6 mice, divided into 4 groups: SAL, ELASTASE CONTROL (EC), ELASTASE I PREVENTIVE ANTI-IL-17 (EP), and ELASTASE + THERAPEUTIC ANTI-IL-17 (ET). On the 29th day, animals were anesthetized with thiopental, tracheotomized, and placed on a ventilator to evaluate lung mechanical, exhaled nitric oxide (eNO), and total cells of bronchoalveolar lavage fluid was collected. We performed histological techniques, and linear mean intercept (Lm) was analyzed. Both treatments with anti-IL-17 decreased respiratory resistance and elastance, airway resistance, elastance of pulmonary parenchyma, eNO, and Lm compared with EC. There was reduction in total cells and macrophages in ET compared with EC. Both treatments decreased nuclear factor-kappa B, inducible nitric oxide synthase, matrix metalloproteinase (MMP)-9, MMP-12, transforming growth factor-beta, tumor necrosis factor-alpha, neutrophils, IL-1 beta, isoprostane, and IL-17 in airways and alveolar septa; collagen fibers, decorin and lumican in airways; and elastic fibers and fibronectin in alveolar septa compared with EC. There was reduction of collagen fibers in alveolar septa and biglycan in airways in EP and a reduction of eNO synthase in airways in ET. In conclusion, both treatments with anti-IL-17 contributed to improve most of parameters evaluated in inflammation and extracellular matrix remodeling in this model of lung injury.eng
dc.description.sponsorshipCapesCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico and Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
dc.description.sponsorshipHCFMUSP, Brazil
dc.language.isoeng
dc.publisherAMER PHYSIOLOGICAL SOCeng
dc.relation.ispartofAmerican Journal of Physiology-Cell Physiology
dc.rightsrestrictedAccesseng
dc.subjectairway remodelingeng
dc.subjectinflammationeng
dc.subjectinterleukin-17eng
dc.subjectpancreatic elastaseeng
dc.subjectpulmonary emphysemaeng
dc.subject.othermatrix metalloproteinaseseng
dc.subject.otherextracellular-matrixeng
dc.subject.otherinduced sputumeng
dc.subject.othertissue-repaireng
dc.subject.otherinflammationeng
dc.subject.othercopdeng
dc.subject.otheremphysemaeng
dc.subject.otherdiseaseeng
dc.subject.otherexacerbationseng
dc.subject.otherexpressioneng
dc.titlePreventive and therapeutic effect of anti-IL-17 in an experimental model of elastase-induced lung injury in C57Bl6 miceeng
dc.typearticleeng
dc.rights.holderCopyright AMER PHYSIOLOGICAL SOCeng
dc.identifier.doi10.1152/ajpcell.00017.2020
dc.identifier.pmid33326311
dc.subject.wosCell Biologyeng
dc.subject.wosPhysiologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalARISTOTELES, Luciana R. C. R. B.:Univ Sao Paulo, Sch Med, Fac Med, Sao Paulo, SP, Brazil
hcfmusp.author.externalSOUZA, Flavia C. R.:Univ Sao Paulo, Sch Med, Fac Med, Sao Paulo, SP, Brazil
hcfmusp.description.beginpageC341
hcfmusp.description.endpageC354
hcfmusp.description.issue3
hcfmusp.description.volume320
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000630438800004
hcfmusp.origem.id2-s2.0-85102909361
hcfmusp.publisher.cityBETHESDAeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1522-1563
hcfmusp.citation.scopus2-
hcfmusp.scopus.lastupdate2022-06-30-
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