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https://observatorio.fm.usp.br/handle/OPI/406
Título: | Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols? |
Autor(es): | LOTTENBERG, Ana Maria; BOMBO, Renata P. A.; ILHA, Angela; NUNES, Valeria Sutti; NAKANDAKARE, Edna R.; QUINTAO, Eder C. R. |
Parte de: | IUBMB LIFE, v.64, n.4, p.296-306, 2012 |
Resumo: | The plasma cholesterol-reducing effect of phytosterols (PS) has been recognized in several studies, but the usefulness of PS in preventing coronary heart disease remains controversial, as some investigations claim that the high PS concentrations found in plasma and specific tissues are related to an increased risk of cardiovascular events. It has also been demonstrated that PS may induce inflammation and reduce cholesterol efflux from macrophages, conditions that are directly implicated in the development of atherosclerosis. As to arterial dysfunction and atherosclerosis, some studies have concluded that plasma PS concentrations are unrelated or only weakly related or that PS intake or plasma PS concentrations are harmful. Thus, in light of the National Cholesterol Education Program-ATPIII report, it is necessary to evaluate the relevance of their findings. To this end, we have evaluated the studies conducted on cells, animal models, and humans regarding the influence of PS on the development of atherosclerosis. |
Aparece nas coleções: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/10 |
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art_LOTTENBERG_Do_clinical_and_experimental_investigations_support_an_antiatherogenic_2012_eng.pdf | publishedVersion (English) | 906.25 kB | Adobe PDF | Visualizar/Abrir |
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