Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/40761
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGIORDANO, Mario Vicente
dc.contributor.authorALVARENGA, Tatiana Fonseca
dc.contributor.authorBASTOS JUNIOR, Cesar de Souza
dc.contributor.authorGIORDANO, Mario Gaspare
dc.contributor.authorBARACAT, Edmund Chada
dc.contributor.authorSOARES JUNIOR, Jose Maria
dc.date.accessioned2021-06-17T13:54:10Z-
dc.date.available2021-06-17T13:54:10Z-
dc.date.issued2021
dc.identifier.citationGYNECOLOGICAL ENDOCRINOLOGY, v.37, n.5, p.467-470, 2021
dc.identifier.issn0951-3590
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40761-
dc.description.abstractObjective: To assess cyclin D1 and PTEN immunoexpression in benign endometrial polyps (EPs) in asymptomatic postmenopausal women and its correlation with obesity. Methods: This was a cross-sectional study based on data from a sample of 52 patients diagnosed with EP between February 2018 and January 2019. The women included in this study were amenorrheal for at least 1 year and were asymptomatic (no postmenopausal bleeding). Obesity defined by body mass index (BMI) was investigated for correlation with Cyclin-D1 and PTEN gene expression (immunohistochemistry) in glandular and stromal compartments of polyps. Results: No significant differences among groups were identified in any clinical and epidemiological parameter (age, age of menopause, time since menopause, number of gestations, polyp size, leucocyte count, fasting blood glucose and basic pathologies), except for BMI. Body mass index did not alter PTEN or Cyclin D1 immunoexpression. Conclusion: Our study shows that obesity does not appear to be a relevant factor in the immunoexpression of PTEN and Cyclin D1 in benign EP, in either the stromal or glandular compartments.eng
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTDeng
dc.relation.ispartofGynecological Endocrinology
dc.rightsrestrictedAccesseng
dc.subjectPolypseng
dc.subjectendometriumeng
dc.subjectobesityeng
dc.titleDoes obesity modify the expression of cyclin D1 and pten in endometrial polyps in postmenopausal women?eng
dc.typearticleeng
dc.rights.holderCopyright TAYLOR & FRANCIS LTDeng
dc.identifier.doi10.1080/09513590.2020.1862787
dc.identifier.pmid33345649
dc.subject.wosEndocrinology & Metabolismeng
dc.subject.wosObstetrics & Gynecologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalALVARENGA, Tatiana Fonseca:Univ Fed Rio de Janeiro, Hystol, Rio De Janeiro, Brazil
hcfmusp.author.externalBASTOS JUNIOR, Cesar de Souza:Univ Fed Rio de Janeiro, Gynecol, Rio De Janeiro, Brazil
hcfmusp.author.externalGIORDANO, Mario Gaspare:Univ Fed Rio de Janeiro, Gynecol, Rio De Janeiro, Brazil
hcfmusp.description.beginpage467
hcfmusp.description.endpage470
hcfmusp.description.issue5
hcfmusp.description.volume37
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000600734400001
hcfmusp.origem.id2-s2.0-85097889043
hcfmusp.publisher.cityABINGDONeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceAbrao F, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000012304eng
hcfmusp.relation.referenceAli IU, 2000, JNCI-J NATL CANCER I, V92, P861, DOI 10.1093/jnci/92.11.861eng
hcfmusp.relation.referenceBussaglia E, 2000, HUM PATHOL, V31, P312, DOI 10.1016/S0046-8177(00)80244-0eng
hcfmusp.relation.referenceChen RC, 2018, CELL DEATH DIS, V10, DOI 10.1038/s41419-018-1207-4eng
hcfmusp.relation.referenceCobellis L, 2008, J ANAT, V213, P464, DOI 10.1111/j.1469-7580.2008.00963.xeng
hcfmusp.relation.referenceCosta-Paiva L, 2011, MENOPAUSE, V18, P1278, DOI 10.1097/gme.0b013e31821e23a1eng
hcfmusp.relation.referenceFerrazzi E, 2009, AM J OBSTET GYNECOL, V200, DOI 10.1016/j.ajog.2008.09.876eng
hcfmusp.relation.referenceFuste NP, 2016, ONCOTARGET, V7, P26979, DOI 10.18632/oncotarget.8876eng
hcfmusp.relation.referenceGreep, 1973, HDB PHYSIOLOGY ENDOC, P615eng
hcfmusp.relation.referenceGuzeloglu-Kayisli O, 2003, J CLIN ENDOCR METAB, V88, P5017, DOI 10.1210/jc.2003-030414eng
hcfmusp.relation.referenceJaniec-Jankowska A, 2010, INT J GYNECOL CANCER, V20, P196, DOI 10.1111/IGC.0b013e3181c83675eng
hcfmusp.relation.referenceKhabaz MN, 2017, ANN DIAGN PATHOL, V30, P47, DOI 10.1016/j.anndiagpath.2017.04.006eng
hcfmusp.relation.referenceLong ME, 2013, J LOW GENIT TRACT DI, V17, P142, DOI 10.1097/LGT.0b013e318260e32feng
hcfmusp.relation.referenceMutter GL, 2000, JNCI-J NATL CANCER I, V92, P924, DOI 10.1093/jnci/92.11.924eng
hcfmusp.relation.referenceOzuysal Sema, 2005, Archives of Gynecology and Obstetrics, V271, P123, DOI 10.1007/s00404-003-0595-5eng
hcfmusp.relation.referencePerri T, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.03.036eng
hcfmusp.relation.referencePinheiro A, 2014, MOL MED REP, V9, P2335, DOI 10.3892/mmr.2014.2125eng
hcfmusp.relation.referenceReeves GK, 2007, BRIT MED J, V335, P1134, DOI 10.1136/bmj.39367.495995.AEeng
hcfmusp.relation.referenceShih HC, 2003, HUM PATHOL, V34, P471, DOI 10.1016/S0046-8177(03)00124-2eng
hcfmusp.relation.referenceSoslow RA, 2000, INT J GYNECOL PATHOL, V19, P329, DOI 10.1097/00004347-200010000-00006eng
hcfmusp.relation.referenceWestin SN, 2015, MOL ONCOL, V9, P1694, DOI 10.1016/j.molonc.2015.04.014eng
hcfmusp.relation.referenceWethington SL, 2011, ANN SURG ONCOL, V18, P3819, DOI 10.1245/s10434-011-1815-zeng
hcfmusp.relation.referenceWik E, 2013, CLIN CANCER RES, V19, P1094, DOI 10.1158/1078-0432.CCR-12-3039eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1473-0766
hcfmusp.citation.scopus1-
hcfmusp.scopus.lastupdate2023-01-27-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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