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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGIORDANO, Mario Vicente
dc.contributor.authorALVARENGA, Tatiana Fonseca
dc.contributor.authorBASTOS JUNIOR, Cesar de Souza
dc.contributor.authorGIORDANO, Mario Gaspare
dc.contributor.authorBARACAT, Edmund Chada
dc.contributor.authorSOARES JUNIOR, Jose Maria
dc.identifier.citationGYNECOLOGICAL ENDOCRINOLOGY, v.37, n.5, p.467-470, 2021
dc.description.abstractObjective: To assess cyclin D1 and PTEN immunoexpression in benign endometrial polyps (EPs) in asymptomatic postmenopausal women and its correlation with obesity. Methods: This was a cross-sectional study based on data from a sample of 52 patients diagnosed with EP between February 2018 and January 2019. The women included in this study were amenorrheal for at least 1 year and were asymptomatic (no postmenopausal bleeding). Obesity defined by body mass index (BMI) was investigated for correlation with Cyclin-D1 and PTEN gene expression (immunohistochemistry) in glandular and stromal compartments of polyps. Results: No significant differences among groups were identified in any clinical and epidemiological parameter (age, age of menopause, time since menopause, number of gestations, polyp size, leucocyte count, fasting blood glucose and basic pathologies), except for BMI. Body mass index did not alter PTEN or Cyclin D1 immunoexpression. Conclusion: Our study shows that obesity does not appear to be a relevant factor in the immunoexpression of PTEN and Cyclin D1 in benign EP, in either the stromal or glandular compartments.eng
dc.publisherTAYLOR & FRANCIS LTDeng
dc.relation.ispartofGynecological Endocrinology
dc.titleDoes obesity modify the expression of cyclin D1 and pten in endometrial polyps in postmenopausal women?eng
dc.rights.holderCopyright TAYLOR & FRANCIS LTDeng
dc.subject.wosEndocrinology & Metabolismeng
dc.subject.wosObstetrics & Gynecologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Tatiana Fonseca:Univ Fed Rio de Janeiro, Hystol, Rio De Janeiro, Brazil JUNIOR, Cesar de Souza:Univ Fed Rio de Janeiro, Gynecol, Rio De Janeiro, Brazil, Mario Gaspare:Univ Fed Rio de Janeiro, Gynecol, Rio De Janeiro, Brazil
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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